Results 81 to 90 of about 114,870 (312)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Economic loss estimation for earthquake hazard in Istanbul [PDF]

Natural hazards, especially earthquakes, cause disasters when they hit large settlements such as metropolitan areas. After the first shock, the damage is counted by deaths and injuries.
Seda Kundak
core  

Assessment of flood loss model transferability considering changes in precaution of flood-affected residents in Germany

E3S Web of Conferences, 2016
Common models that are used for flood loss assessments today rarely include multiple loss influencing factors, e.g. private precautionary measures, which is increasingly gaining attention in the course of the changes towards an integrated flood risk ...
Kienzler Sarah, Kreibich Heidi, Müller Meike, Pech Ina, Thieken Annegret H.   +4 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Past, Present, and Future of Wetlands Credit Sales [PDF]

In this paper we review the evolution of the wetlands credit sales program developed to support the federal wetlands permit program. Then, we explain how the regulatory rules governing the overall permit program, as well as specific rules governing ...
Shabman, Leonard, Scodari, Paul
core  

Leveraging Multifaceted Polyphenol Interactions: An Approach for Hair Loss Mitigation

Advanced Materials Interfaces
Hair loss affects millions globally, creating a demand for safer, more effective treatments. Traditional treatments like minoxidil often have limited efficacy and side effects.
Eunu Kim, Geon Min Lee, Haeshin Lee
doaj   +1 more source

The impacts of U.S. withdrawal from the Paris Agreement on the carbon emission space and mitigation cost of China, EU, and Japan under the constraints of the global carbon emission space

Advances in Climate Change Research, 2017
Based on the Computable General Equilibrium (CGE) model and scenario analysis, the impacts of the U.S. withdrawal from the Paris Agreement on the carbon emission space and mitigation cost in China, European Union (EU), and Japan are assessed under ...
Han-Cheng Dai, Hai-Bin Zhang, Wen-Tao Wang   +2 more
doaj   +1 more source

Use of Kaolin-Impregnated Gauze Aids in Hemostasis and Blood Loss Mitigation in a Penetrating Injury to the Bladder and Small Bowel. [PDF]

Cureus, 2023
Campbell B, Castater C, Smith RN, Sciaretta JD, Nguyen J.   +4 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source