Results 1 to 10 of about 91,099 (345)

Loss of Heterozygosity and Its Importance in Evolution. [PDF]

J Mol Evol, 2023
Loss of heterozygosity (LOH) is a mitotic recombination event that converts heterozygous loci to homozygous loci. This mutation event is widespread in organisms that have asexual reproduction like budding yeasts, and is also an important and frequent ...
Smukowski Heil C.
europepmc   +4 more sources

JLOH: Inferring loss of heterozygosity blocks from sequencing data. [PDF]

Comput Struct Biotechnol J, 2023
Heterozygosity is a genetic condition in which two or more alleles are found at a genomic locus. Individuals that are the offspring of genetically divergent yet still interfertile parents (e.g. hybrids) are highly heterozygous.
Schiavinato M, Del Olmo V, Muya VN, Gabaldón T.   +3 more
europepmc   +2 more sources

Targeting Loss of Heterozygosity: A Novel Paradigm for Cancer Therapy

Pharmaceuticals, 2021
Loss of heterozygosity (LOH) is a common genetic event in the development of cancer. In certain tumor types, LOH can affect more than 20% of the genome, entailing loss of allelic variation in thousands of genes.
Xiaonan Zhang, Tobias Sjöblom
doaj   +2 more sources

Loss of heterozygosity of CYP2D6 enhances the sensitivity of hepatocellular carcinomas to talazoparib. [PDF]

EBioMedicine
Summary: Background: Loss of heterozygosity (LOH) diminishes genetic diversity within cancer genomes. A tumour arising in an individual heterozygous for a functional and a loss-of-function (LoF) allele of a gene occasionally retain only the LoF allele ...
Zhang X, Rameika N, Zhong L, Rendo V, Veanes M, Kundu S, Nuciforo S, Dupuis J, Al Azhar M, Tsiara I, Seeburger P, Al Nassralla S, Ljungström V, Svensson R, Stoimenov I, Artursson P, Heim MH, Globisch D, Sjöblom T.   +18 more
europepmc   +2 more sources

Loss of Heterozygosity associated with ubiquitous environments in yeast. [PDF]

PLoS Genet
The effect of ubiquitous environmental conditions on mutational mechanisms, particularly loss of heterozygosity (LOH) remains poorly understood. Environment induced LOH can rapidly alter the genome and promote disease progression.
Vijayan N, Joshi S, Sarath P, Nishant KT.   +3 more
europepmc   +2 more sources

Clonal dynamics following p53 loss of heterozygosity in Kras-driven cancers

Nature Communications, 2016
Using mosaic analysis with double markers to label genetically-distinct clones in established tumors, the authors studied the effects of p53 loss in lung and pancreatic cancers.
Mandar Deepak Muzumdar, Kimberly Judith Dorans, Katherine Minjee Chung, Rebecca Robbins, Tuomas Tammela, Vasilena Gocheva, Carman Man-Chung Li, Tyler Jacks   +7 more
doaj   +2 more sources

CRISPR-Cas9 Editing Induces Loss of Heterozygosity in the Pathogenic Yeast Candida parapsilosis. [PDF]

mSphere, 2022
Genetic manipulation is often used to study gene function. However, unplanned genome changes (including single nucleotide polymorphisms [SNPs], aneuploidy, and loss of heterozygosity [LOH]) can affect the phenotypic traits of the engineered strains. Here,
Lombardi L, Bergin SA, Ryan A, Zuniga-Soto E, Butler G.   +4 more
europepmc   +2 more sources

Cerebral venous thrombosis with hyperhomocysteinemia due to loss of heterozygosity at methylenetetrahydrofolate reductase (MTHFR) locus: a case report. [PDF]

BMC Neurol, 2023
Background Loss of heterozygosity (LOH) at methylenetetrahydrofolate reductase (MTHFR) locus has been reported in tumor tissue. But the mutation was never reported in cerebral venous thrombosis (CVT) with hyperhomocysteinemia (HHcy) before.
Zhang M, Shi B, Zhao M.
europepmc   +2 more sources

PB1836: LOSS OF HETEROZYGOSITY IN AML PATIENTS WITH INV(16) [PDF]

Hemasphere, 2023
Bessmertniy D, Fidarova Z, Lukyanova I, Risinskaya N, Sudarikov A.   +4 more
europepmc   +2 more sources

Loss of heterozygosity exploited for collateral lethality-based cancer therapy. [PDF]

EBioMedicine
Fang H.
europepmc   +2 more sources