CRISPR-Cas9 Editing Induces Loss of Heterozygosity in the Pathogenic Yeast Candida parapsilosis [PDF]
mSphere, 2022 Genetic manipulation is often used to study gene function. However, unplanned genome changes (including single nucleotide polymorphisms [SNPs], aneuploidy, and loss of heterozygosity [LOH]) can affect the phenotypic traits of the engineered strains. Here,
Lisa Lombardi +4 more
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JLOH: Inferring loss of heterozygosity blocks from sequencing data [PDF]
Computational and Structural Biotechnology Journal, 2023 Heterozygosity is a genetic condition in which two or more alleles are found at a genomic locus. Individuals that are the offspring of genetically divergent yet still interfertile parents (e.g. hybrids) are highly heterozygous.
Matteo Schiavinato +3 more
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Loss of heterozygosity of CYP2D6 enhances the sensitivity of hepatocellular carcinomas to talazoparibResearch in context [PDF]
EBioMedicineSummary: Background: Loss of heterozygosity (LOH) diminishes genetic diversity within cancer genomes. A tumour arising in an individual heterozygous for a functional and a loss-of-function (LoF) allele of a gene occasionally retain only the LoF allele ...
Xiaonan Zhang +18 more
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Loss of Heterozygosity associated with ubiquitous environments in yeast. [PDF]
PLoS GeneticsThe effect of ubiquitous environmental conditions on mutational mechanisms, particularly loss of heterozygosity (LOH) remains poorly understood. Environment induced LOH can rapidly alter the genome and promote disease progression.
Nikilesh Vijayan +3 more
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A new method to detect loss of heterozygosity using cohort heterozygosity comparisons [PDF]
BMC Cancer, 2010 Background Loss of heterozygosity (LOH) is an important marker for one of the 'two-hits' required for tumor suppressor gene inactivation. Traditional methods for mapping LOH regions require the comparison of both tumor and patient-matched normal DNA ...
Lea Rod A +6 more
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Loss of heterozygosity of TRIM3 in malignant gliomas [PDF]
BMC Cancer, 2009 Background Malignant gliomas are frequent primary brain tumors associated with poor prognosis and very limited response to conventional chemo- and radio-therapies.
Dolder Béatrice +5 more
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Cerebral venous thrombosis with hyperhomocysteinemia due to loss of heterozygosity at methylenetetrahydrofolate reductase (MTHFR) locus: a case report [PDF]
BMC Neurology, 2023 Background Loss of heterozygosity (LOH) at methylenetetrahydrofolate reductase (MTHFR) locus has been reported in tumor tissue. But the mutation was never reported in cerebral venous thrombosis (CVT) with hyperhomocysteinemia (HHcy) before.
Mingjie Zhang, Bingxin Shi, Mangsuo Zhao
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PB1836: LOSS OF HETEROZYGOSITY IN AML PATIENTS WITH INV(16) [PDF]
HemaSphere, 2023 Dmitry Bessmertniy +4 more
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Loss of heterozygosity drives clonal diversity of Phytophthora capsici in China. [PDF]
PLoS ONE, 2013 Phytophthora capsici causes significant loss to pepper (Capsicum annum) in China and our goal was to develop single nucleotide polymorphism (SNP) markers for P. capsici and characterize genetic diversity nationwide. Eighteen isolates of P.
Jian Hu +8 more
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Loss of heterozygosity exploited for collateral lethality-based cancer therapy [PDF]
EBioMedicineHai Fang
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