Loss of Heterozygosity and Its Importance in Evolution. [PDF]
J Mol Evol, 2023 Loss of heterozygosity (LOH) is a mitotic recombination event that converts heterozygous loci to homozygous loci. This mutation event is widespread in organisms that have asexual reproduction like budding yeasts, and is also an important and frequent ...
Smukowski Heil C.
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Targeting Loss of Heterozygosity: A Novel Paradigm for Cancer Therapy
Pharmaceuticals, 2021 Loss of heterozygosity (LOH) is a common genetic event in the development of cancer. In certain tumor types, LOH can affect more than 20% of the genome, entailing loss of allelic variation in thousands of genes.
Xiaonan Zhang, Tobias Sjöblom
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JLOH: Inferring loss of heterozygosity blocks from sequencing data [PDF]
Computational and Structural Biotechnology Journal, 2023 Heterozygosity is a genetic condition in which two or more alleles are found at a genomic locus. Individuals that are the offspring of genetically divergent yet still interfertile parents (e.g. hybrids) are highly heterozygous.
Matteo Schiavinato +3 more
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Loss of Heterozygosity associated with ubiquitous environments in yeast. [PDF]
PLoS GeneticsThe effect of ubiquitous environmental conditions on mutational mechanisms, particularly loss of heterozygosity (LOH) remains poorly understood. Environment induced LOH can rapidly alter the genome and promote disease progression.
Nikilesh Vijayan +3 more
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Clonal dynamics following p53 loss of heterozygosity in Kras-driven cancers
Nature Communications, 2016 Using mosaic analysis with double markers to label genetically-distinct clones in established tumors, the authors studied the effects of p53 loss in lung and pancreatic cancers.
Mandar Deepak Muzumdar +7 more
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Cerebral venous thrombosis with hyperhomocysteinemia due to loss of heterozygosity at methylenetetrahydrofolate reductase (MTHFR) locus: a case report [PDF]
BMC Neurology, 2023 Background Loss of heterozygosity (LOH) at methylenetetrahydrofolate reductase (MTHFR) locus has been reported in tumor tissue. But the mutation was never reported in cerebral venous thrombosis (CVT) with hyperhomocysteinemia (HHcy) before.
Mingjie Zhang, Bingxin Shi, Mangsuo Zhao
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CRISPR-Cas9 Editing Induces Loss of Heterozygosity in the Pathogenic Yeast Candida parapsilosis [PDF]
mSphere, 2022 Genetic manipulation is often used to study gene function. However, unplanned genome changes (including single nucleotide polymorphisms [SNPs], aneuploidy, and loss of heterozygosity [LOH]) can affect the phenotypic traits of the engineered strains. Here,
Lisa Lombardi +4 more
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Value of the loss of heterozygosity to BRCA1 variant classification [PDF]
npj Breast Cancer, 2022 At least 10% of the BRCA1/2 tests identify variants of uncertain significance (VUS) while the distinction between pathogenic variants (PV) and benign variants (BV) remains particularly challenging.
Elizabeth Santana dos Santos +25 more
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PB1836: LOSS OF HETEROZYGOSITY IN AML PATIENTS WITH INV(16) [PDF]
HemaSphere, 2023 Dmitry Bessmertniy +4 more
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Loss of heterozygosity exploited for collateral lethality-based cancer therapy [PDF]
EBioMedicineHai Fang
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