Results 11 to 20 of about 89,986 (324)

Loss of heterozygosity of TRIM3 in malignant gliomas [PDF]

BMC Cancer, 2009
Background Malignant gliomas are frequent primary brain tumors associated with poor prognosis and very limited response to conventional chemo- and radio-therapies.
Dolder Béatrice, Taylor Elisabeth, Stiefel Urs, Boulay Jean-Louis, Merlo Adrian, Hirth Frank   +5 more
doaj   +5 more sources

Loss of heterozygosity: what is it good for? [PDF]

BMC Medical Genomics, 2015
Loss of heterozygosity (LOH) is a common genetic event in cancer development, and is known to be involved in the somatic loss of wild-type alleles in many inherited cancer syndromes.
G. Ryland, M. Doyle, D. Goode, Samantha E. Boyle, David Y. H. Choong, Simone M. Rowley, Jason Li, D. Bowtell, R. Tothill, I. Campbell, Kylie L. Gorringe   +10 more
semanticscholar   +5 more sources

A new method to detect loss of heterozygosity using cohort heterozygosity comparisons [PDF]

BMC Cancer, 2010
Background Loss of heterozygosity (LOH) is an important marker for one of the 'two-hits' required for tumor suppressor gene inactivation. Traditional methods for mapping LOH regions require the comparison of both tumor and patient-matched normal DNA ...
Lea Rod A, Wellwood Jeremy, Wood Peter, Jardine Paul, Green Michael R, Marlton Paula, Griffiths Lyn R   +6 more
doaj   +5 more sources

Targeting tumor vulnerabilities associated with loss of heterozygosity [PDF]

Molecular & Cellular Oncology, 2020
We show that N-acetyltransferase 2 (NAT2) loss of heterozygosity can be targeted in >4% of colorectal cancers with the use of a small molecule. We identify and describe the effect of a compound that impairs the growth of colorectal tumors with slow NAT2 ...
Veronica Rendo, Ivaylo Stoimenov, Tobias Sjöblom   +2 more
doaj   +5 more sources

The dynamics of loss of heterozygosity events in genomes. [PDF]

EMBO Rep
Abstract Genomic instability is a hallmark of tumorigenesis, yet it also plays an essential role in evolution. Large-scale population genomics studies have highlighted the importance of loss of heterozygosity (LOH) events, which have long been overlooked in the context of genetic diversity and instability.
Dutta A, Schacherer J.
europepmc   +3 more sources

Disruption of the circadian clock drives Apc loss of heterozygosity to accelerate colorectal cancer

Science Advances, 2022
An alarming rise in young onset colorectal cancer (CRC) has been reported; however, the underlying molecular mechanism remains undefined. Suspected risk factors of young onset CRC include environmental aspects, such as lifestyle and dietary factors ...
Sung Kook Chun, B. Fortin, R. Fellows, Amber N. Habowski, A. Verlande, Wei A Song, Alisa L Mahieu, Austin E Y T Lefebvre, Jason N. Sterrenberg, L. M. Velez, M. Digman, R. Edwards, Nicholas R. Pannunzio, M. Seldin, M. Waterman, S. Masri   +15 more
semanticscholar   +1 more source

Targeting loss of heterozygosity for cancer-specific immunotherapy

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance The lack of viable tumor-specific targets continues to thwart efforts to implement selective anticancer drugs in the clinic. Clonal loss of heterozygosity (LOH) occurs in the great majority of human tumors and represents an irreversible ...
Michael S. Hwang, B. Mog, J. Douglass, Alexander H. Pearlman, E. Hsiue, S. Paul, S. DiNapoli, M. Konig, D. Pardoll, S. Gabelli, C. Bettegowda, N. Papadopoulos, B. Vogelstein, Shibin Zhou, K. Kinzler   +14 more
semanticscholar   +1 more source

Ataxia-Telangiectasia Mutated Loss of Heterozygosity in Melanoma. [PDF]

Int J Mol Sci, 2022
ATM germline pathogenic variants were recently found enriched in high-risk melanoma patients. However, ATM loss of heterozygosity (LOH) has never been investigated in melanoma and, therefore, a causal association with melanoma development has not been established yet.
Pastorino L, Dalmasso B, Allavena E, Vanni I, Ugolini F, Baroni G, Croce M, Guadagno A, Cabiddu F, Andreotti V, Bruno W, Zoppoli G, Ferrando L, Tanda ET, Spagnolo F, Menin C, Gangemi R, Massi D, Ghiorzo P.   +18 more
europepmc   +6 more sources

Frequent loss of heterozygosity in CRISPR-Cas9–edited early human embryos

Proceedings of the National Academy of Sciences of the United States of America, 2020
CRISPR-Cas9 genome editing is a promising technique for clinical applications, such as the correction of disease-associated alleles in somatic cells. The use of this approach has also been discussed in the context of heritable editing of the human germ ...
Gregorio Alanis-Lobato, Jasmin Zohren, Afshan Mccarthy, N. Fogarty, N. Kubikova, Emily Hardman, M. Greco, D. Wells, James M. A. Turner, K. Niakan   +9 more
semanticscholar   +1 more source

Loss of Heterozygosity

Definitions, 2020
A 65-year-old man with gastric cancer underwent distal gastrectomy in November 2001, i.e., radical D2 resection with curability A. Histopathological findings were tub2, type2, mp, ly1, v1, and n0. In October 2003, he suf-fered melena.

semanticscholar   +1 more source