Results 21 to 30 of about 89,986 (324)

Loss of heterozygosity in tuberous sclerosis hamartomas. [PDF]

Journal of Medical Genetics, 1996
We have previously described in tuberous sclerosis (TSC) hamartomas the phenomenon of loss of heterozygosity (LOH) for DNA markers in the region of both the TSC2 gene on chromosome 16p13.3 and the TSC1 gene on 9q34. We now describe the spectrum of LOH in 51 TSC hamartomas from 34 cases of TSC.
Tiina Sepp, John R.W. Yates, Andrew Green   +2 more
openalex   +5 more sources

Molecular clonality analysis of esophageal adenocarcinoma by multiregion sequencing of tumor samples

BMC Research Notes, 2017
Background Intratumor heterogeneity has been demonstrated in several cancer types, following a model of branched evolution. It is unknown to which extent intratumor heterogeneity is applicable to esophageal adenocarcinoma. Therefore the aim of this study
Anna M. J. van Nistelrooij, Ronald van Marion, Linetta B. Koppert, Katharina Biermann, Manon C. W. Spaander, Hugo W. Tilanus, J. Jan B. van Lanschot, Bas P. L. Wijnhoven, Winand N. M. Dinjens   +8 more
doaj   +1 more source

Molecular and clinicopathological analysis of three cases of gastric juvenile polyposis

JGH Open, 2022
Background and Aim Juvenile polyposis (JP) is a rare disease known to be associated with mutations either in SMAD4/BMPR1A. JP is known to often develop into malignant tumors, with a reported probability of 9–50%.
Yuya Yamashiro, Yuka Yanai, Tsutomu Takeda, Takuo Hayashi, Yoichi Akazawa, Noboru Yatagai, Hiroya Ueyama, Hidetaka Eguchi, Akihito Nagahara, Takashi Yao, Tsuyoshi Saito   +10 more
doaj   +1 more source

High incidence of microsatellite instability and loss of heterozygosity in three loci in breast cancer patients receiving chemotherapy: a prospective study

BMC Cancer, 2012
Background The aim of the study was to evaluate potential chemotherapy-induced microsatellite instability, loss of heterozygosity, loss of expression in mismatch repair proteins and associations with clinical findings in breast cancer patients ...
Kamat Nasir, Khidhir Mohammed A, Jaloudi Mohammed, Hussain Sabir, Alashari Mouied M, Al Qawasmeh Khaled H, Rannug Ulf   +6 more
doaj   +1 more source

Genetic alterations of tumor suppressor gene in sporadic colorectal cancers [PDF]

Glasnik Antropološkog Društva Srbije, 2012
Colorectal cancer with its frequency, high mortality rate as well as many etiological unknowns is a challenge to contemporary science. Finally, genetic information could be used in near future for prevention of colorectal cancer, its early diagnosis and ...
Hadžiavdić Vesna, Eminović Izet, Hamidović Hajrija, Pavlović-Čalić Nada   +3 more
doaj   +1 more source

Loss of heterozygosity (LOH)--implications for human genetic identification.

Folia Histochemica et Cytobiologica, 2009
The aim of this study was assessment of possible effects of loss of heterozygosity on human genetic identification of histolopathogical tissue sections. DNA templates were extracted from tumour tissue specimens excised from oncological patients and from ...
Jerzy Janica, Tomasz Filipowski, Leszek Kozłowski, Renata Zalewska, Marek Rogowski, Małgorzata Skawrońska, Ireneusz Sołtyszewski, Witold Pepiński   +7 more
doaj   +1 more source

Loss of heterozygosity of essential genes represents a widespread class of potential cancer vulnerabilities

bioRxiv, 2019
Alterations in non-driver genes represent an emerging class of potential therapeutic targets in cancer. Hundreds to thousands of non-driver genes undergo loss of heterozygosity (LOH) events per tumor, generating discrete differences between tumor and ...
C. Nichols, W. Gibson, Meredith S. Brown, Jack A. Kosmicki, John P. Busanovich, Hope Y. Wei, Laura Urbanski, Naomi Curimjee, Ashton C. Berger, G. Gao, A. Cherniack, S. Dhe-Paganon, B. Paolella, R. Beroukhim   +13 more
semanticscholar   +1 more source

Loss of Heterozygosities in Five Tumor Suppressor Genes (FHIT Gene, p16, pRb, E-Cadherin and p53) in Thyroid Tumors [PDF]

Clinical and Experimental Otorhinolaryngology, 2014
ObjectivesTo evaluate the loss of heterozygosities (LOH) of chromosomes 3p14 (FHIT gene), 9p21 (p16), 13q21 (pRb), 6q22 (E-cadherin) and 17p13 (p53) in various thyroid tumors.MethodsEighty thyroid tumor cases (20 follicular adenomas, 10 follicular ...
Jin Hwan Kim, Kyu Young Choi, Dong Jin Lee, Young-Soo Rho, Sung-Jin Jo   +4 more
doaj   +1 more source

The Genome of the Human Pathogen Candida albicans Is Shaped by Mutation and Cryptic Sexual Recombination

mBio, 2018
The opportunistic fungal pathogen Candida albicans lacks a conventional sexual program and is thought to evolve, at least primarily, through the clonal acquisition of genetic changes. Here, we performed an analysis of heterozygous diploid genomes from 21
Joshua M. Wang, Richard J. Bennett, Matthew Z. Anderson   +2 more
doaj   +1 more source

Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy

Nature Communications, 2020
Allelic losses occurring in cancer cells have been suggested as potential targets for therapy. Here, the authors show how recurring loss of heterozygosity of a drug metabolic gene in colorectal cancers can be exploited using a low molecular weight ...
Veronica Rendo, Ivaylo Stoimenov, André Mateus, Elin Sjöberg, Richard Svensson, Anna-Lena Gustavsson, Lars Johansson, Adrian Ng, Casey OʼBrien, Marios Giannakis, Per Artursson, Peter Nygren, Ian Cheong, Tobias Sjöblom   +13 more
doaj   +1 more source