Results 21 to 30 of about 138,753 (343)

The DNA damage checkpoint pathway promotes extensive resection and nucleotide synthesis to facilitate homologous recombination repair and genome stability in fission yeast. [PDF]

, 2014
DNA double-strand breaks (DSBs) can cause chromosomal rearrangements and extensive loss of heterozygosity (LOH), hallmarks of cancer cells. Yet, how such events are normally suppressed is unclear.
Blaikley, EJ, Bähler, J, Deegan, RS, Hulme, L, Humphrey, TC, Hussey, S, Kasparek, TR, Marguerat, S, Nakagawa, T, Pai, CC, Sarkar, S, Tinline-Purvis, H, Walker, CA, Wee, BY   +13 more
core   +1 more source

Gene surfing [PDF]

, 2007
Spatially resolved genetic data is increasingly used to reconstruct the migrational history of species. To assist such inference, we study, by means of simulations and analytical methods, the dynamics of neutral gene frequencies in a population ...
Allee, Austerlitz, Austerlitz, Brunet, Brunet, Cavalli-Sforza, Courchamp, Crow, Currat, Dahmen, David R. Nelson, Desai, Doering, Edmonds, Fisher, Gaggiotti, Hartl, Hewitt, Hewitt, Kingman, Klopfstein, Le Corre, Liu, Moran, Murray, Nagylaki, Nagylaki, Nagylaki, Nichols, Notohara, Oskar Hallatschek, Panja, Pease, Phillips, Pulliam, Ramachandran, Rosenberg, Rouzine, Templeton, Tsimring, van Kampen, van Saarloos, Vlad, Wilkins   +43 more
core   +2 more sources

Loss of heterozygosity (LOH)--implications for human genetic identification.

Folia Histochemica et Cytobiologica, 2009
The aim of this study was assessment of possible effects of loss of heterozygosity on human genetic identification of histolopathogical tissue sections. DNA templates were extracted from tumour tissue specimens excised from oncological patients and from ...
Jerzy Janica, Tomasz Filipowski, Leszek Kozłowski, Renata Zalewska, Marek Rogowski, Małgorzata Skawrońska, Ireneusz Sołtyszewski, Witold Pepiński   +7 more
doaj   +1 more source

Recombining your way out of trouble: the genetic architecture of hybrid fitness under environmental stress [PDF]

, 2020
Hybridization between species is a fundamental evolutionary force that can both promote and delay adaptation. There is a deficit in our understanding of the genetic basis of hybrid fitness, especially in non-domesticated organisms.
Bendixsen, D., Greig, D., Janzen, T., Nolte, A., Stelkens, R., Zhang, Z.   +5 more
core   +1 more source

Evaluation of Heterozygosity Loss in STR-Loci of Tumor DNA in Multiple Myeloma Patients with Plasmacytoma Based on the Molecular Analysis of Complex Archival Tumor Samples

Клиническая онкогематология, 2022
Background. Multiple myeloma (MM) is a hematological malignancy with plasma cells as substrate. Sometimes MM is characterized by plasmacytomas, i.e., intra- and extraosseous tumors.
Elena Evgen’evna Nikulina, M. V. Firsova, N. V. Risinskaya, Ya. A. Kozhevnikova, M. V. Solov’ev, T. V. Abramova, T. N. Obukhova, A. M. Kovrigina, A. B. Sudarikov, L. P. Mendeleeva   +9 more
doaj   +1 more source

Imaging correlates of molecular signatures in oligodendrogliomas. [PDF]

, 2004
Molecular subsets of oligodendroglioma behave in biologically distinct ways. Their locations in the brain, rates of growth, and responses to therapy differ with their genotypes. Retrospectively, we inquired whether allelic loss of chromosomal arms 1p and
Betensky, Rebecca A, Cairncross, J Gregory, Forsyth, Peter A, Kachur, Edward, Lee, Donald H, Louis, David N, Megyesi, Joseph F, Mizoguchi, Masahiro, Okada, Yoshifumi, Sasaki, Hikaru, Zlatescu, Magdalena C   +10 more
core   +2 more sources

The Genome of the Human Pathogen Candida albicans Is Shaped by Mutation and Cryptic Sexual Recombination

mBio, 2018
The opportunistic fungal pathogen Candida albicans lacks a conventional sexual program and is thought to evolve, at least primarily, through the clonal acquisition of genetic changes. Here, we performed an analysis of heterozygous diploid genomes from 21
Joshua M. Wang, Richard J. Bennett, Matthew Z. Anderson   +2 more
doaj   +1 more source

Multiple-locus heterozygosity, physiology and growth at two different stages in the life cycle of the Chilean oyster Ostrea chilensis [PDF]

, 1996
A random sample of 150 individuals of a laboratory-produced cohort of Ostrea chilensis Philippi, 1845 was taken at 10 and 36 mo of age to estimate physiological variables and individual heterozygosity using 4 loci (Lap, Pgi, Pgm and Ca).
Gallegillos, R., Toro, J.E., Vergara, A.M.   +2 more
core   +2 more sources

Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy

Nature Communications, 2020
Allelic losses occurring in cancer cells have been suggested as potential targets for therapy. Here, the authors show how recurring loss of heterozygosity of a drug metabolic gene in colorectal cancers can be exploited using a low molecular weight ...
Veronica Rendo, Ivaylo Stoimenov, André Mateus, Elin Sjöberg, Richard Svensson, Anna-Lena Gustavsson, Lars Johansson, Adrian Ng, Casey OʼBrien, Marios Giannakis, Per Artursson, Peter Nygren, Ian Cheong, Tobias Sjöblom   +13 more
doaj   +1 more source

Value of the loss of heterozygosity to BRCA1 variant classification

npj Breast Cancer, 2022
At least 10% of the BRCA1/2 tests identify variants of uncertain significance (VUS) while the distinction between pathogenic variants (PV) and benign variants (BV) remains particularly challenging.
Elizabeth Santana dos Santos, Amanda B. Spurdle, Dirce M. Carraro, Adrien Briaux, Melissa Southey, Giovana Torrezan, Ambre Petitalot, Raphael Leman, Philippe Lafitte, kConFab Investigators, Didier Meseure, Keltouma Driouch, Lucy Side, Carole Brewer, Sarah Beck, Athalie Melville, Alison Callaway, Françoise Revillion, Maria A. A. Koike Folgueira, Michael T. Parsons, Heather Thorne, Anne Vincent-Salomon, Dominique Stoppa-Lyonnet, Ivan Bieche, Sandrine M. Caputo, Etienne Rouleau   +25 more
doaj   +1 more source