Results 21 to 30 of about 2,755,429 (311)
BMC Cancer, 2012 Background The aim of the study was to evaluate potential chemotherapy-induced microsatellite instability, loss of heterozygosity, loss of expression in mismatch repair proteins and associations with clinical findings in breast cancer patients ...
Kamat Nasir +6 more
doaj +1 more source
Loss of heterozygosity (LOH)--implications for human genetic identification.
Folia Histochemica et Cytobiologica, 2009 The aim of this study was assessment of possible effects of loss of heterozygosity on human genetic identification of histolopathogical tissue sections. DNA templates were extracted from tumour tissue specimens excised from oncological patients and from ...
Jerzy Janica +7 more
doaj +1 more source
Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy
Nature Communications, 2020 Allelic losses occurring in cancer cells have been suggested as potential targets for therapy. Here, the authors show how recurring loss of heterozygosity of a drug metabolic gene in colorectal cancers can be exploited using a low molecular weight ...
Veronica Rendo +13 more
doaj +1 more source
Loss of Heterozygosities in Five Tumor Suppressor Genes (FHIT Gene, p16, pRb, E-Cadherin and p53) in Thyroid Tumors [PDF]
Clinical and Experimental Otorhinolaryngology, 2014 ObjectivesTo evaluate the loss of heterozygosities (LOH) of chromosomes 3p14 (FHIT gene), 9p21 (p16), 13q21 (pRb), 6q22 (E-cadherin) and 17p13 (p53) in various thyroid tumors.MethodsEighty thyroid tumor cases (20 follicular adenomas, 10 follicular ...
Jin Hwan Kim +4 more
doaj +1 more source
Theoretical Population Biology, 73 (1), p. 158, 2008., 2007 Spatially resolved genetic data is increasingly used to reconstruct the migrational history of species. To assist such inference, we study, by means of simulations and analytical methods, the dynamics of neutral gene frequencies in a population undergoing a continual range expansion in one dimension.
arxiv +1 more source
mBio, 2018 The opportunistic fungal pathogen Candida albicans lacks a conventional sexual program and is thought to evolve, at least primarily, through the clonal acquisition of genetic changes. Here, we performed an analysis of heterozygous diploid genomes from 21
Joshua M. Wang +2 more
doaj +1 more source
Reclassification of oligoastrocytomas by loss of heterozygosity studies [PDF]
International Journal of Cancer, 2006 AbstractOligoastrocytomas (OAs) are WHO grade II or III tumors composed of a mixture of 2 neoplastic cell types morphologically resembling the cells in oligodendrogliomas and diffuse astrocytomas. Investigations on the genetic profile of OAs may yield important information for their classification and help for their clinical management. We have studied,
Maria Grazia Bruzzone +11 more
openaire +3 more sources
Targeting Loss of Heterozygosity: A Novel Paradigm for Cancer Therapy
Pharmaceuticals, 2021 Loss of heterozygosity (LOH) is a common genetic event in the development of cancer. In certain tumor types, LOH can affect more than 20% of the genome, entailing loss of allelic variation in thousands of genes.
Xiaonan Zhang, Tobias Sjöblom
doaj +1 more source
Loss of heterozygosity in oral cancer
Oral Science International, 2011 AbstractThe development and progression of oral squamous cell carcinoma (OSCC) is a multistep process, which involves many genetic factors. Among them, loss of heterozygosity (LOH) studies have been used to identify regions on chromosomes that may contain putative tumor suppressor genes (TSGs).
Kazuaki Fushimi +9 more
openaire +2 more sources
Total consensus under high reproductive-variance conditions [PDF]
arXiv, 2022 Star-shaped branching patterns of genealogies are common in marine species. High-fecundity marine populations are characterized by low ratios of effective to actual population size, which reflect high variance in reproductive success among parents in mass spawns.
arxiv