Results 31 to 40 of about 89,986 (324)

BRCA locus-specific loss of heterozygosity in germline BRCA1 and BRCA2 carriers

Nature Communications, 2017
Complete loss of BRCA1 or BRCA2 function is associated with sensitivity to DNA damaging agents. However, not all BRCA1 and BRCA2 germline mutation-associated tumors respond.
K. Maxwell, B. Wubbenhorst, Brandon M. Wenz, Daniel De Sloover, J. Pluta, Lyndsey Emery, A. Barrett, A. Kraya, Ioannis Anastopoulos, Shun Yu, Yuchao Jiang, Hao Chen, Nancy R. Zhang, Nicole M. Hackman, K. D’Andrea, R. Daber, J. Morrissette, N. Mitra, M. Feldman, S. Domchek, K. Nathanson   +20 more
semanticscholar   +1 more source

Allele-specific genome editing using CRISPR–Cas9 is associated with loss of heterozygosity in diploid yeast

bioRxiv, 2018
Targeted DNA double-strand breaks (DSBs) with CRISPR-Cas9 have revolutionized genetic modification by enabling efficient genome editing in a broad range of eukaryotic systems.
Arthur R Gorter de Vries, Lucas G. F. Couwenberg, Marcel van den Broek, Pilar de la Torre Cortés, Jolanda ter Horst, J. Pronk, J. Daran   +6 more
semanticscholar   +1 more source

Loss of heterozygosity in oral cancer

Oral Science International, 2011
AbstractThe development and progression of oral squamous cell carcinoma (OSCC) is a multistep process, which involves many genetic factors. Among them, loss of heterozygosity (LOH) studies have been used to identify regions on chromosomes that may contain putative tumor suppressor genes (TSGs).
Kazuaki Fushimi, Katsuya Usukura, Takashi Ishigami, Hideki Tanzawa, Kazuyuki Koike, Katsunori Ogawara, Atsushi Kasamatsu, Masashi Shiiba, Dai Nakashima, Katsuhiro Uzawa   +9 more
openaire   +2 more sources

Reclassification of oligoastrocytomas by loss of heterozygosity studies [PDF]

International Journal of Cancer, 2006
AbstractOligoastrocytomas (OAs) are WHO grade II or III tumors composed of a mixture of 2 neoplastic cell types morphologically resembling the cells in oligodendrogliomas and diffuse astrocytomas. Investigations on the genetic profile of OAs may yield important information for their classification and help for their clinical management. We have studied,
Maria Grazia Bruzzone, Donatella Bianchessi, Carmelo Maccagnano, Lorena Bissola, Gaetano Finocchiaro, Amerigo Boiardi, Antonio Silvani, Tiziana De Simone, Lorella Valletta, Marica Eoli, Bianca Pollo, Giovanni Broggi   +11 more
openaire   +3 more sources

Loss of Heterozygosity Drives Adaptation in Hybrid Yeast

Molecular biology and evolution, 2017
Hybridization is often considered maladaptive, but sometimes hybrids can invade new ecological niches and adapt to novel or stressful environments better than their parents.
Caiti Smukowski Heil, Christopher G. DeSevo, Dave A. Pai, C. M. Tucker, M. Hoang, Maitreya J. Dunham   +5 more
semanticscholar   +1 more source

Microsatellite Instability and Loss of Heterozygosity in Melanoma

Journal of Investigative Dermatology, 1995
Alterations in the repeat length of microsatellites have been identified recently in tumors arising in patients with hereditary nonpolyposis colon cancer and in several human sporadic tumors. We examined 40 sporadic melanomas and their corresponding nontumorous skin for microsatellite instability (MSI) and loss of heterozygosity (LOH) at chromosomes 2q,
Peris, Ketty, Keller, G, Chimenti, S, Amantea, A, Kerl, H, Höfler, H.   +5 more
openaire   +4 more sources

The cell cycle stage of bovine zygotes electroporated with CRISPR/Cas9-RNP affects frequency of Loss-of-heterozygosity editing events

Scientific Reports, 2022
At the embryonic level, CRISPR technologies have been used to edit genomes reliably and efficiently in various mammalian models, with Ribonucleoprotein (RNP) electroporation potentially representing a superior delivery method into mammalian zygotes ...
Dennis Miskel, Mikhael Poirier, Luisa Beunink, Franca Rings, Eva Held, Ernst Tholen, Dawit Tesfaye, Karl Schellander, Dessie Salilew-Wondim, Carina Blaschka, Christine Große-Brinkhaus, Brenig Bertram, Michael Hoelker   +12 more
doaj   +1 more source

Familial Adenomatous Polyposis: Analysis of Genetic Instability of Microsatellites Loci and Genetic Alternations of Tumor Suppressor Genes

Biomolecules & Biomedicine, 2008
Familial adenomatous polyposis (FAP) is an autosomal dominant illness with the highest risk for appearance of colorectal cancer’s disease. In our study, we have used Bethesda criteria that define colorectal cancers which can be tested on microsatellite ...
Vesna Hadžiavdić, Izet Eminović, Mensura Aščerić, Radovan Komel   +3 more
doaj   +1 more source

Patterns of Genomic Instability in Interspecific Yeast Hybrids With Diverse Ancestries

Frontiers in Fungal Biology, 2021
The genomes of hybrids often show substantial deviations from the features of the parent genomes, including genomic instabilities characterized by chromosomal rearrangements, gains, and losses.
Devin P. Bendixsen, David Peris, David Peris, Rike Stelkens   +3 more
doaj   +1 more source

Loss of heterozygosity at the CYP2D6 locus in breast cancer: implications for germline pharmacogenetic studies.

Journal of the National Cancer Institute, 2015
BACKGROUND Controversy exists regarding the impact of CYP2D6 genotype on tamoxifen responsiveness. We examined loss of heterozygosity (LOH) at the CYP2D6 locus and determined its impact on genotyping error when tumor tissue is used as a DNA source ...
M. Goetz, James X. Sun, V. Suman, Grace O. Silva, C. M. Perou, Yusuke Nakamura, N. Cox, P. Stephens, V. Miller, J. Ross, David J. Chen, Stephanie L. Safgren, M. Kuffel, M. Ames, K. Kalari, H. Gómez, A. González-Angulo, O. Burgués, H. Brauch, J. Ingle, M. Ratain, R. Yelensky   +21 more
semanticscholar   +1 more source