Results 21 to 30 of about 405 (122)

The novel isoxazoline ectoparasiticide lotilaner (Credelio™): a non-competitive antagonist specific to invertebrates γ-aminobutyric acid-gated chloride channels (GABACls)

Parasites & Vectors, 2017
Background The isoxazolines are a novel class of parasiticides that are potent inhibitors of γ-aminobutyric acid (GABA)-gated chloride channels (GABACls) and, to a lesser extent, of inhibitory glutamate-gated chloride channels (GluCls).
Lucien Rufener, Vanessa Danelli, Daniel Bertrand, Heinz Sager   +3 more
doaj   +2 more sources

Laboratory evaluations of the immediate and sustained effectiveness of lotilaner (Credelio™) against three common species of ticks affecting dogs in Europe

Parasites & Vectors, 2017
Background There is a continuing need for novel approaches to tick control in dogs. One such approach lies in the ability of lotilaner (Credelio™), an isoxazoline with a rapid onset of action, to provide sustained efficacy against ticks. Two studies were
Daniela Cavalleri, Martin Murphy, Regina Lizundia Gorbea, Wolfgang Seewald, Jason Drake, Steve Nanchen   +5 more
doaj   +2 more sources

The mosquitocidal activity of isoxazoline derivatives afoxolaner, lotilaner, and fluralaner are not affected by mosquito sugar or antibiotic treatment [PDF]

Scientific Reports
Long-lasting insecticidal nets and indoor residual sprays have played a major role in significantly reducing the burden of malaria. However, the management of mosquitoes resistant to current insecticides continues to be challenging.
Katharine Collins, Harouna Söre, Koen Dechering   +2 more
exaly   +4 more sources

Laboratory evaluation of the speed of kill of lotilaner (Credelio™) against Ixodes ricinus ticks on dogs

Parasites & Vectors, 2017
Background With the geographical expansion of tick species and increased recognition of pathogens they transmit, there is a requirement for safe and rapidly effective control measures for dogs.
Martin Murphy, Daniela Cavalleri, Wolfgang Seewald, Jason Drake, Steve Nanchen   +4 more
doaj   +2 more sources

Assessment of the speed of flea kill of lotilaner (Credelio™) throughout the month following oral administration to dogs

Parasites & Vectors, 2017
Background Lotilaner (Credelio™, Elanco), a novel isoxazoline, is a systemic insecticide and acaricide that is rapidly absorbed following oral administration to dogs and has a half-life of 30 days.
Daniela Cavalleri, Martin Murphy, Wolfgang Seewald, Jason Drake, Steve Nanchen   +4 more
doaj   +2 more sources

Laboratory evaluation of the efficacy of lotilaner (Credelio™) against Amblyomma cajennense (sensu lato) infestations of dogs

Parasites & Vectors, 2018
Background The ixodid tick Amblyomma cajennense (sensu lato) complex, widespread throughout South and Central America, is also present in Mexico, Texas and Florida.
Pedro Veloso Facury Lasmar, Martin Murphy, Steve Nanchen, Jason Drake, Katherina Coumendouros, Debora Azevedo Borges, Priscila Cardim de Oliveira, Fábio Barbour Scott   +7 more
doaj   +2 more sources

Laboratory evaluations of the 3-month efficacy of oral lotilaner (Credelio™) against experimental infestations of dogs with the Australian paralysis tick, Ixodes holocyclus

Parasites & Vectors, 2018
Background From three days following host attachment, the Australian paralysis tick, Ixodes holocyclus, secretes a neurotoxin that annually causes paralysis in approximately 10,000 domestic pets.
Kim Baker, Claudia Ellenberger, Martin Murphy, Daniela Cavalleri, Wolfgang Seewald, Jason Drake, Steve Nanchen, Kristina Hacket   +7 more
doaj   +2 more sources

A randomized, controlled study to assess the efficacy and safety of lotilaner (Credelio™) in controlling ticks in client-owned dogs in Europe

Parasites & Vectors, 2017
Background Oral administration of lotilaner flavoured chewable tablets (Credelio™, Elanco) to dogs has been shown to provide a rapid onset of killing activity of infesting ticks, with sustained efficacy for at least 35 days.
Daniela Cavalleri, Martin Murphy, Wolfgang Seewald, Jason Drake, Steve Nanchen   +4 more
doaj   +2 more sources

Efficacy of Credelio Quattro™ chewable tablets containing lotilaner, moxidectin, pyrantel, and praziquantel against Ctenocephalides felis and Rhipicephalus sanguineus infestations on dogs [PDF]

Parasites & Vectors
Background Fleas and ticks can be found globally and are of both veterinary and human health concern due to their ability to transmit various vector-borne diseases.
Lisa Young, Xinshuo Wang, Scott Wiseman, William R. Everett, Riaan Maree, Utami R. DiCosty, Carin Rautenbach, Molly D. Savadelis   +7 more
doaj   +2 more sources

Efficacy of a novel chewable tablet (Credelio Quattro™) containing lotilaner, moxidectin, praziquantel, and pyrantel for the prevention of heartworm disease (Dirofilaria immitis) in dogs [PDF]

Parasites & Vectors
Background Canine heartworm (Dirofilaria immitis), a filarial parasite endemic in many countries worldwide, can cause life-threatening disease in dogs if left untreated.
Lisa Young, Craig R. Reinemeyer, Mansour Abdelmoneim, Scott Wiseman   +3 more
doaj   +2 more sources