Results 21 to 30 of about 464 (144)
Parasites & Vectors, 2017 Background Lotilaner is a novel isoxazoline developed for oral administration to dogs. In laboratory studies, lotilaner was shown to be safe and to produce a rapid flea and tick knockdown, with a sustained speed of kill for at least a month post ...
Daniela Cavalleri +4 more
doaj +2 more sources
Lotilaner Ophthalmic Solution, 0.25%, for the Treatment of Demodex Blepharitis. [PDF]
Healthcare (Basel)Demodex blepharitis, a chronic lid margin disease, is caused by an infestation of Demodex mites, the most common ectoparasites in human skin and eyelids. Lotilaner ophthalmic solution, 0.25% (Xdemvy, Tarsus Pharmaceuticals), is the first therapy approved to treat Demodex blepharitis.
Davey PG +7 more
europepmc +4 more sources
Pharmacokinetics of lotilaner following a single oral or intravenous administration in cats [PDF]
Parasites & Vectors, 2018 Background CredelioTM (lotilaner) is an oral ectoparasiticide from the isoxazoline class developed for the treatment of flea and tick infestations in cats. It is formulated as a pure S-enantiomer in flavoured chewable tablets.
Céline E. Toutain +2 more
doaj +3 more sources
Parasites & Vectors, 2017 Background The oral systemic efficacy of lotilaner (Credelio™, Elanco) was evaluated against Demodex spp. in naturally infested dogs with generalized demodicosis.
Daniel E. Snyder +2 more
doaj +2 more sources
Parasites & Vectors, 2018 Background Lotilaner is approved for dogs as a chewable tablet formulation. It has separately been developed for oral administration in cats (Credelio™ chewable tablets for cats) to meet the need for an easy to use, safe and rapidly effective ...
Daniela Cavalleri +3 more
doaj +2 more sources
A randomized, controlled field study to assess the efficacy and safety of lotilaner flavored chewable tablets (Credelio™) in eliminating fleas in client-owned dogs in the USA [PDF]
Parasites & Vectors, 2017 Background Preclinical studies have shown that the novel isoxazoline, lotilaner (Credelio™, Elanco) administered orally to dogs, produces rapid flea and tick knockdown and sustained speed of kill for at least a month post-treatment with a wide safety ...
Daniela Karadzovska +7 more
doaj +2 more sources
Parasites & Vectors, 2017 Background The isoxazolines are a novel class of parasiticides that are potent inhibitors of γ-aminobutyric acid (GABA)-gated chloride channels (GABACls) and, to a lesser extent, of inhibitory glutamate-gated chloride channels (GluCls).
Lucien Rufener +3 more
doaj +2 more sources
Parasites & Vectors, 2017 Background There is a continuing need for novel approaches to tick control in dogs. One such approach lies in the ability of lotilaner (Credelio™), an isoxazoline with a rapid onset of action, to provide sustained efficacy against ticks. Two studies were
Daniela Cavalleri +5 more
doaj +2 more sources
Parasites & Vectors, 2018 Background The ixodid tick Amblyomma cajennense (sensu lato) complex, widespread throughout South and Central America, is also present in Mexico, Texas and Florida.
Pedro Veloso Facury Lasmar +7 more
doaj +2 more sources
Parasites & Vectors, 2018 Background From three days following host attachment, the Australian paralysis tick, Ixodes holocyclus, secretes a neurotoxin that annually causes paralysis in approximately 10,000 domestic pets.
Kim Baker +7 more
doaj +2 more sources