Results 61 to 70 of about 464 (144)

Safety of oral afoxolaner formulated with or without milbemycin oxime in homozygous MDR1‐deficient collie dogs

Journal of Veterinary Pharmacology and Therapeutics, Volume 45, Issue 4, Page 373-379, July 2022., 2022
Abstract Afoxolaner, an insecticide and acaricide compound of the isoxazoline class, is available for dogs as an oral ectoparasiticide medicine (NexGard®) and as an oral endectoparasiticide medicine in combination with milbemycin oxime (MO), a macrocyclic lactone (NexGard® Spectra).
Marlene Drag, Eric Tielemans, Elizabeth Mitchell   +2 more
wiley   +1 more source

Molecular Targets of Neurotoxic Insecticides in Apis mellifera

European Journal of Organic Chemistry, Volume 2022, Issue 21, June 7, 2022., 2022
Cloning of the honeybee genes encoding ion channels targeted by neurotoxic insecticides and their functional reconstitution in heterologous expression system allow the assessment of the different insecticide classes including pyrethroids and neonicotinoids. Elucidation of their mode of action, by combining electrophysiology and molecular docking, might
Thierry Cens, Alain Chavanieu, Anaïs Bertaud, Nawfel Mokrane, Sébastien Estaran, Julien Roussel, Claudine Ménard, Marie‐Celeste De Jesus Ferreira, Janique Guiramand, Jean‐Baptiste Thibaud, Catherine Cohen‐Solal, Matthieu Rousset, Valérie Rolland, Michel Vignes, Pierre Charnet   +14 more
wiley   +1 more source

First Report of Bronchial Oestriasis in a Domestic Dog. [PDF]

Vet Med Sci
Oestrus ovis bronchial myasis is described in a dog for the first time. Bronchoscopy proved essential for larval visualization and removal. Isoxazoline compounds should be considered both as a treatment and as a preventive option. ABSTRACT This study reports the first case of bronchial myiasis in a dog caused by Oestrus ovis, a parasite known to infest
Dini FM, Raponi F, Vallone F, Galuppi R, Macchioni F.   +4 more
europepmc   +2 more sources

Current review of isoxazoline ectoparasiticides used in veterinary medicine

Journal of Veterinary Pharmacology and Therapeutics, Volume 45, Issue 1, Page 1-15, January 2022., 2022
Abstract The isoxazolines are a novel class of ectoparasiticides with potent inhibitory activity on glutamate‐ and gamma‐aminobutyric acid‐gated chloride channel located in nervous system of invertebrates. In recent years, studies have been performed to evaluate the efficacy and safety of isoxazolines against various types of ectoparasites, including ...
Xueying Zhou, Alexandra E. Hohman, Walter H. Hsu   +2 more
wiley   +1 more source

Functional Characterization of the Cat and Dog Wild-Type and Mutant MDR1 Carrier Proteins and Frequency of the MDR1 Gene Mutation in 800 Cats From Germany. [PDF]

J Vet Pharmacol Ther
ABSTRACT The ATP‐binding cassette transporter MDR1 P‐glycoprotein (syn. ABCB1) is an efflux carrier at the cell membrane that regulates drug absorption, distribution, and elimination. At the blood–brain barrier, MDR1 restricts brain entry of potentially neurotoxic drugs, such as ivermectin. In dogs and cats, MDR1 (syn.
Siegl L, Bethäuser M, Nürnberger D, Oswald S, Moritz A, Hamann M, Geyer J.   +6 more
europepmc   +2 more sources

Efficacy evaluation of lotilaner (Credelio™) in experimentally induced Otodectes cynotis infestations in cats. [PDF]

Parasit Vectors
Abstract Background The ear mite, Otodectes cynotis , is pathogenic, highly contagious and a global cause of otitis externa and pruritus in cats and dogs.
Hayes B, Viljoen A, Rouenhoff S, Mehrotra S, Michler S, Ahlstrom L, Krämer F, Schunack B.   +7 more
europepmc   +3 more sources

The 2023 World Small Animal Veterinary Association (WSAVA)

, 2023
Journal of Small Animal Practice, Volume 64, Issue 12, Page 731-748, December 2023.
P. V. Steagall, L. Pelligand, S. Page, J. L. Granick, F. Allerton, P. M. Bęczkowski, J. S. Weese, A. K. Hrček, F. Queiroga, L. Guardabassi   +9 more
wiley   +1 more source

A randomized, controlled field study to assess the efficacy and safety of lotilaner (Credelio™) in controlling fleas in client-owned cats in Europe

Parasites & Vectors, 2018
Background Lotilaner is a new isoxazoline developed as an oral ectoparasiticide for cats and dogs. Its safety, rapid killing onset of action and sustained speed of fleas and ticks kill for a minimum of one month after administration, were demonstrated in
Daniela Cavalleri, Martin Murphy, Wolfgang Seewald, Steve Nanchen   +3 more
doaj   +1 more source

Collarette Elimination and Demodex Mite Eradication with Topical Lotilaner Ophthalmic Solution, 0.25%

Journal of Ocular Pharmacology and Therapeutics, 2021
Purpose: To evaluate the efficacy of topical lotilaner ophthalmic solution, 0.25%, in patients with Demodex blepharitis. Methods:
Roberto Gonzalez-Salinas, Elizabeth Yeu, Mark Holdbrook, Stephanie N. Baba, Juan Carlos Ceballos, Martha Massaro-Corredor, Claudia Corredor-Ortega, Nallely Ramos-Betancourt, Hugo Quiroz-Mercado   +8 more
openaire   +2 more sources

Acaricidal Activity Of The Orally Administered Isoxazoline Drugs (Lotilaner, Fluralaner, And Afoxolaner) In White-Footed Mice Against Larval Ticks [PDF]

, 2023
Lyme disease, caused by Borrelia burgdorferi, is currently the most prevalent vector borne disease in North America. With the CDC estimating almost 500,000 new cases every year, methods are needed to control the vector, the black legged tick (Ixodes ...
Gisi, Emily Marie
core   +1 more source