Modulation of HER2 internalization enhances single-dose antibody-drug potency in HER2+ gastric cancer [PDF]
Scientific ReportsHER2 is a membrane receptor tyrosine kinase overexpressed in 18–20% of gastric tumors. Trastuzumab emtansine (T-DM1) is an antibody-drug conjugate (ADC) that targets HER2-positive (HER2+) cancer cells with a chemotherapeutic agent, emtansine.
Abbey Zidel +9 more
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Anti-proliferative and apoptotic effects of Lovastatin on K562 Erthromyloidy cancer cell line
مجله دانشگاه علوم پزشکی گرگان, 2017 Background and Objective: Lovastatin is a HMG-CoA reductase inhibitor and used for the treatment of hypercholesterolemia. Inhibition of HMG-CoA reductase results in inhibiting the activity of the Ras proto-oncogene that has mutations in most cancers ...
M Vaezi, M Mohammadzadeh, Y Pazhang
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Shipin gongye ke-ji, 2023 Objective: To establish a quantitative analysis of multi-components by single marker (QAMS) method for the determination of lovastatin and lovastatin acid for the quality control of Hongqu Fuling tablets.
Yingli ZHU +9 more
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BMC Cancer, 2023 Background Lovastatin, an HMG-CoA inhibitor and an effective cholesterol lowering drug, exhibits anti-neoplastic activity towards several types of cancer, although the underlying mechanism is still not fully understood.
Jian Gao +12 more
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Inhibition of NF-κB Pathway and Modulation of MAPK Signaling Pathways in Glioblastoma and Implications for Lovastatin and Tumor Necrosis Factor-Related Apoptosis Inducing Ligand (TRAIL) Combination Therapy. [PDF]
PLoS ONE, 2017 Glioblastoma is a common malignant brain tumor and it is refractory to therapy because it usually contains a mixture of cell types. The tumor necrosis factor-related apoptosis inducing ligand (TRAIL) has been shown to induce apoptosis in a range of tumor
Pi Chu Liu +8 more
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Differential effects of lovastatin on cisplatin responses in normal human mesothelial cells versus cancer cells: implication for therapy. [PDF]
PLoS ONE, 2012 The cancer killing efficacy of standard chemotherapeutic agents such as cisplatin (CDDP) is limited by their side effects to normal tissues. Therefore, research efforts optimizing the safety and efficacy of those agents are clinically relevant.
Yandong Shi +3 more
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Effects of naturally-produced lovastatin on feed digestibility, rumen fermentation, microbiota and methane emissions in goats over a 12-week treatment period. [PDF]
PLoS ONE, 2018 Twenty male Saanen goats were randomly assigned to four levels of lovastatin supplementation and used to determine the optimal dosage and sustainability of naturally produced lovastatin from fermentation of palm kernel cake (PKC) with Aspergillus terreus
Su Chui Len Candyrine +12 more
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The Iraqi Journal of Veterinary Medicine, 2020 An interaction toxicity study was performed to evaluate and compare the effect of P-glycoprotein (P-gp) inhibitor (captopril) and inducer (spironolactone) on their common substrate (lovastatin) that were done by comparing LD50 of the acute study with ...
Mohammed A. Aboktifa, Duraid A. Abbas
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Medicina, 2023 Background and Objectives: We have recently reported that Fluvastatin, Atorvastatin, Simvastatin and Rosuvastatin have calcium channel antagonistic activities using rabbits’ intestinal preparations.
Wajid Ali +4 more
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Locally delivered lovastatin-containing chitosan nanoparticles promote bone regeneration in rats [PDF]
The Ukrainian Biochemical Journal, 2021 Hypolipidemic statins can stimulate osteoregeneration. However, such effects are observed only after administration methods that are unacceptable for patients (prolonged infusions or huge oral doses).
O. O. Shevchuk +2 more
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