Results 11 to 20 of about 18,198 (190)

Statins in Breast Cancer Therapy: Mechanistic Insights and Emerging Evidence. [PDF]

Cancer Innov
Statins, particularly simvastatin, demonstrate potential as adjuvant agents in breast cancer treatment by disrupting tumour cell signalling and survival pathways. This review highlights emerging evidence supporting their repurposing for improved outcomes, especially in aggressive breast cancer subtypes.
Alim R, Akalanka HMK.
europepmc   +2 more sources

Lovastatin reversed the enhanced sphingomyelin caused by 27-hydroxycholesterol in cultured vascular endothelial cells

Biochemistry and Biophysics Reports, 2016
Statins have pleiotropic properties which are involved in inhibiting the thrombogenic response. In this study, the effects of lovastatin on two phospholipids, phosphatidylcholine and sphingomyelin, were studied in cultured endothelial cells in the ...
Qi Zhou, Allan Luo, Fred A Kummerow
doaj   +1 more source

Pengaruh Saccharomyces cerevisiae terhadap kadar lovastatin dalam angkak yang dihasilkan dari fermentasi beras oleh Monascus purpureus jmbA

Journal of Biological Researches, 2012
Fermented rice by Monascus purpureus, namely angkak, produces lovastatin. Lovastatin has been believed and studied as anti hypercholesterolemic agent.
Evi Triana, Novik Nurhidayat
doaj   +1 more source

Production of Lovastatin using Liquid Cheese Whey by Fusarium nectrioides (MH173849), an Endophytic Fungi Isolated from Euphorbia hirta

Journal of Pure and Applied Microbiology, 2022
Lovastatin is a naturally produced 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase enzyme inhibitor- used for treating hypercholesterolemia.
Senthamarai Manogaran, Kannan Kilavan Packiam, Vijayakumar Lakshmi Narayanan, Chadhurthika Krishnamurthy, Devi Vijayarangam, Moni Philip Jacob Kizhakedathil   +5 more
doaj   +1 more source

Role of cholesterol synthesis in regulation of bile acid synthesis and biliary cholesterol secretion in humans.

Journal of Lipid Research, 1991
We used lovastatin, a specific inhibitor of HMG-CoA reductase, to study the role of cholesterol synthesis in regulation of both bile acid synthesis, measured by release of 14CO2 from [26-14C]cholesterol, and biliary cholesterol secretion, measured by ...
JC Mitchell, BG Stone, GM Logan, WC Duane   +3 more
doaj   +1 more source

In Vivo and in Vitro Study on Drug-Drug Interaction of Lovastatin and Berberine from Pharmacokinetic and HepG2 Cell Metabolism Studies

Molecules, 2016
Background: We assumed that the pharmacokinetics of lovastatin could be changed by the induction effect of berberine. Methods: An UPLC-MS/MS method was developed and validated for the pharmacokinetics tudy of lovastatin to investigate the in vivo drug ...
Hanming Cui, Jialong Wang, Qiuyan Zhang, Mengmeng Dang, Hui Liu, Yu Dong, Lu Zhang, Fang Yang, Jianhua Wu, Xiaolin Tong   +9 more
doaj   +1 more source

Utilization of an Industry Byproduct, Corymbia maculata Leaves, by Aspergillus terreus to Produce Lovastatin

Bioengineering, 2020
Due to its ability to lower cholesterol levels, simvastatin is a leading drug for the prevention of strokes and heart disease: it also lowers the incidence of neurodegenerative diseases.
Mishal Subhan, Rani Faryal, Ian Macreadie   +2 more
doaj   +1 more source

Lovastatin protects against experimental plague in mice. [PDF]

PLoS ONE, 2010
BACKGROUND: Plague is an ectoparasite-borne deadly infection caused by Yersinia pestis, a bacterium classified among the group A bioterrorism agents. Thousands of deaths are reported every year in some African countries.
Saravanan Ayyadurai, Hubert Lepidi, Claude Nappez, Didier Raoult, Michel Drancourt   +4 more
doaj   +1 more source

Lovastatin induces multiple stress pathways including LKB1/AMPK activation that regulate its cytotoxic effects in squamous cell carcinoma cells. [PDF]

PLoS ONE, 2012
Cellular stress responses trigger signaling cascades that inhibit proliferation and protein translation to help alleviate the stress or if the stress cannot be overcome induce apoptosis.
Laurie Ma, Nima Niknejad, Ivan Gorn-Hondermann, Khalil Dayekh, Jim Dimitroulakos   +4 more
doaj   +1 more source

Lovastatin Production by Aspergillus sclerotiorum Using Agricultural Waste

Food Technology and Biotechnology, 2020
Research background. Lovastatin is a well-known drug used to reduce hypercholesterolaemia. However, the cost of lovastatin production is still high.
Jutarut Iewkittayakorn, Kannika Kuechoo, Yaowapa Sukpondma, Vatcharin Rukachaisirikul, Souwalak Phongpaichit, Wilaiwan Chotigeat   +5 more
doaj   +1 more source