Results 51 to 60 of about 18,198 (190)

Screening and genetic engineering of marine-derived Aspergillus terreus for high-efficient production of lovastatin

Microbial Cell Factories
Background Lovastatin has widespread applications thanks to its multiple pharmacological effects. Fermentation by filamentous fungi represents the major way of lovastatin production.
Han Na, Yao-yao Zheng, Yaoning Jia, Jingzhao Feng, Jizi Huang, Jihao Huang, Chang-Yun Wang, Guangshan Yao   +7 more
doaj   +1 more source

Stereochemische Entschlüsselung der Strobilurin‐PKS enthüllt die komplexe biosynthetische Logik des iterativen Aufbaus eines EZE‐Triens

Angewandte Chemie, Volume 138, Issue 4, 22 January 2026.
Die iterative Strobilurin‐PKS baut ein bemerkenswertes EZE‐Trien auf, indem es seine S‐tereoselektvität während der Synthese variiert. Die stereoselektive 2R‐Methylierung des Triketid‐Intermediats durch die C‐terminale C‐Methyltransferase‐Domäne induziert die KR‐ und DH‐Domänen ihre native Stereoselektivität umzukehren und ein Z‐konfiguriertes ...
Maurice Hauser, Jing Pang, Daowan Lai, Yunlong Sun, Hao Yao, Russell J. Cox   +5 more
wiley   +1 more source

Understanding the “individual drug reaction” from the perspective of the interaction between probiotics and lovastatin in vitro and in vivo

Microbiome, 2023
Background The existence of the gut microbiota produces an “individual drug reaction.” As members of the intestinal microbiota, probiotics, although they have prebiotic functions, may accelerate the degradation of drugs, thereby affecting drug efficacy ...
Siyuan Shen, Jun Wang, Chenchen Ma, Yanni Chen, Hao Ding, Jiachao Zhang   +5 more
doaj   +1 more source

Stereochemical Dissection of the Strobilurin PKS Reveals the Complex Biosynthetic Logic of Iterative EZE Triene Construction

Angewandte Chemie International Edition, Volume 65, Issue 4, 22 January 2026.
The strobilurin iterative PKS assembles a remarkable EZE triene by varying its stereoselectivity during synthesis. Stereoselective 2R‐methylation of the triketide intermediate by the C‐terminal C‐methyltransferase domain induces the KR and DH domains to invert their native stereoselectivities and produce a Z‐configured intermediate.
Maurice Hauser, Jing Pang, Daowan Lai, Yunlong Sun, Hao Yao, Russell J. Cox   +5 more
wiley   +1 more source

Delayed Respiratory Failure After Sulfuric Acid Mist Inhalation From a Foaming Lead‐Acid Battery

Acute Medicine &Surgery, Volume 13, Issue 1, January/December 2026.
Delayed, progressive lung injury developed after sulfuric acid mist inhalation from a car battery. The patient improved with multimodal care including corticosteroids. This case highlights the need for vigilance in clinical progression and suggests that corticosteroid therapy may be considered in selected severe cases. ABSTRACT Background Sulfuric acid
Rio Saruta, Yuya Suzuki, Kasumi Satoh, Komei Kameyama, Manabu Okuyama, Hajime Nakae   +5 more
wiley   +1 more source

Effects of lovastatin and dietary cholesterol on bile acid kinetics and bile lipid composition in healthy male subjects.

Journal of Lipid Research, 1994
We measured bile acid kinetics and bile lipids in 12 human subjects on a metabolic ward in four randomly allocated, 6-7 week periods: 1) lovastatin (40 mg b.i.d) + low cholesterol diet (mean 246 mg/day); 2) lovastatin+high cholesterol diet (mean 1071 mg ...
W C Duane
doaj   +1 more source

Sumac (Rhus coriaria L.) and Human Metabolic Health: A Systematic Review and Meta‐Analysis

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 1, January 2026.
Sumac (Rhus coriaria L.) supplementation enhances glycemic control and lipid metabolism, indicating potential cardiometabolic benefits in reducing cardiovascular disease risk factors. ABSTRACT Background Rhus coriaria L. (Anacardiaceae), known as Sumac, is a commonly used spice, which is rich in various classes of phytochemicals including flavonoids ...
Ali Jafari, Bahare ParsiNezhad, Minoo AhmadianMoghaddam, Motahareh Hasani, Niloufar Rasaei, Ali Saeedi‐Boroujeni, Gholamreza Roshandel, Sima Besharat, Mahla Chambari, Alireza Alaghi   +9 more
wiley   +1 more source

Extraction, Purification and Evaluation of Bioactivity of Lovastatin From Monascus purpureus Fermented Finger Millet

Food Safety and Health, Volume 4, Issue 1, Page 138-146, January 2026.
A graphical abstract showing lovastatin extraction from Monascus purpureus fermented finger millet. ABSTRACT Red yeast rice (RYR), a traditional fermented food product derived from Monascus purpureus cultivation on rice, has been utilized as both food and food additive throughout East Asian countries for centuries.
Monu Kumar, Gaurav Chaudhary, Anita Rani Sehrawat   +2 more
wiley   +1 more source

Exploring Autophagy Inducing Molecules: Targeting Diverse Pathways in Alzheimer's Disease Management

Medicinal Research Reviews, Volume 46, Issue 1, Page 272-298, January 2026.
ABSTRACT Neurodegenerative disorders, including Alzheimer's disease (AD), impose a significant burden on society due to their progressive nature and the associated healthcare costs. Autophagy, a vital cellular degradation process, has emerged as a promising therapeutic target in these disorders.
Baljinder Singh, Shubham Mahajan, Sadikalmahdi Abdella, Rehan Khan, Sanjay Garg   +4 more
wiley   +1 more source

Controlled release of lovastatin from poly(lactic-co-glycolic acid) nanoparticles for direct pulp capping in rat teeth

International Journal of Nanomedicine, 2017
Hung-Pin Lin,1,2,* Han-Ping Tu,3,* Yu-Ping Hsieh,4 Bor-Shiunn Lee3 1Department of Dentistry, MacKay Memorial Hospital, 2Department of Dentistry, School of Dentistry, National Taiwan University, 3Graduate Institute of Oral Biology, School of Dentistry ...
Lin HP, Tu HP, Hsieh YP, Lee BS
doaj