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Frontiers in Neurology, 2022 Various surgical techniques and pharmaceutical treatments have been developed to improve the current technologies of treating brain diseases. Focused ultrasound (FUS) is a new brain stimulation modality that can exert a therapeutic effect on diseased ...
Hongchae Baek +8 more
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Recent Advances in the Use of Focused Ultrasound as a Treatment for Epilepsy
Frontiers in Neuroscience, 2022 Epilepsy affects about 1% of the population. Approximately one third of patients with epilepsy are drug-resistant (DRE). Resective surgery is an effective treatment for DRE, yet invasive, and not all DRE patients are suitable resective surgery candidates.
Emma Lescrauwaet +9 more
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A review of low-intensity focused ultrasound for neuromodulation [PDF]
Biomedical Engineering Letters, 2017 The ability of ultrasound to be focused into a small region of interest through the intact skull within the brain has led researchers to investigate its potential therapeutic uses for functional neurosurgery and tumor ablation. Studies have used high-intensity focused ultrasound to ablate tissue in localised brain regions for movement disorders and ...
Hongchae, Baek +2 more
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Therapeutic Ultrasound-Enhanced Immune Checkpoint Inhibitor Therapy
Frontiers in Physics, 2021 Immune checkpoint inhibitors (ICIs) are designed to reinvigorate antitumor immune responses by interrupting inhibitory signaling pathways and promote the immune-mediated elimination of malignant cells.
Jinyun Yuan +4 more
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Frontiers in Human Neuroscience, 2022 Low intensity focused ultrasound (LIFU) has been gaining traction as a non-invasive neuromodulation technology due to its superior spatial specificity relative to transcranial electrical/magnetic stimulation.
John Dell'Italia +9 more
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Low-Intensity Focused Ultrasound Modulates Monkey Visuomotor Behavior [PDF]
Current Biology, 2013 In vivo feasibility of using low-intensity focused ultrasound (FUS) to transiently modulate the function of regional brain tissue has been recently tested in anesthetized lagomorphs [1] and rodents [2-4]. Hypothetically, ultrasonic stimulation of the brain possesses several advantages [5]: it does not necessitate surgery or genetic alteration but could
Deffieux, Thomas +5 more
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Measurement of low-intensity highly focused ultrasound [PDF]
The Journal of the Acoustical Society of America, 1986 The requirements for precise determination of acoustic output for different types of medical diagnostic equipment have made it important to develop methods of measuring ultrasonic field parameters at high megahertz range of frequencies. More specifically, of particular interest here is the measurement of pulsed beams of small focal diameters (of the ...
George H. Myers +2 more
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Noninvasive neuromodulation and thalamic mapping with low-intensity focused ultrasound [PDF]
Journal of Neurosurgery, 2018 OBJECTIVEUltrasound can be precisely focused through the intact human skull to target deep regions of the brain for stereotactic ablations. Acoustic energy at much lower intensities is capable of both exciting and inhibiting neural tissues without causing tissue heating or damage.
Robert F, Dallapiazza +7 more
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A review of low-intensity focused ultrasound pulsation
Brain Stimulation, 2011 With the recent approval by the Food and Drug Administration (FDA) of Deep Brain Stimulation (DBS) for Parkinson's Disease, dystonia and obsessive compulsive disorder (OCD), vagus nerve stimulation (VNS) for epilepsy and depression, and repetitive transcranial magnetic stimulation (rTMS) for the treatment of depression, neuromodulation has become ...
Alexander, Bystritsky +8 more
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Noninvasive Low-Intensity Focused Ultrasound Mediates Tissue Protection following Ischemic Stroke
BME Frontiers, 2022 Objective and Impact Statement. This study examined the efficacy and safety of pulsed, low-intensity focused ultrasound (LIFU) and determined its ability to provide neuroprotection in a murine permanent middle cerebral artery occlusion (pMCAO) model ...
Alexandra M. Kaloss +6 more
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