Results 51 to 60 of about 215,416 (267)

Heterogeneity in the Global Practice of Central Nervous System Staging in Pediatric Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) involvement in childhood acute lymphoblastic leukemia (ALL) is assessed by cell counting and cytomorphology from cerebrospinal fluid (CSF) and is used for treatment stratification worldwide. The ratio of “CNS2” patients in clinical trials ranges from 3% to 40%, with unclear prognostic significance ...
Laura Almási, Bernadett Borbála Huszti, Gábor Barna, Marko Kavcic, Janez Jazbec, Lennart Lenk, Vera Münch, Sophia Polychronopoulou, Ágnes Márk, Maria Thastrup, Lüder H. Meyer, Kjeld Schmiegelow, Cornelia Eckert, Christina Halsey, Dániel J. Erdélyi   +14 more
wiley   +1 more source

Cavitation in blast induced traumatic brain injury: the occurrence, mechanism, threshold and implication [PDF]

, 2021
Blast induced traumatic brain injury (BTBI) has been a prevalent injury in recent conflicts, due to the vast use of improvised explosive devices. However, the mechanisms for BTBI remain unclear, particularly those linked to the primary blast waves ...
Yu, Xiancheng
core   +1 more source

Emapalumab for Immune Effector Cell‐Associated Hemophagocytic Lymphohistiocytosis‐Like Syndrome Following CD19‐Directed CAR‐T in Two Patients With B‐ALL: Clinical and Biomarker Correlates

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Immune effector cell‐associated hemophagocytic lymphohistiocytosis‐like syndrome (IEC‐HS) is a life‐threatening hyperinflammatory toxicity distinct from cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T‐cell (CAR‐T) therapy. In a single‐institution retrospective cohort of pediatric and young adult patients
Thomas J. Galletta, Jeremy D. Rubinstein, Christopher E. Dandoy, Ruby Khoury, Angela Faulhaber, Christine L. Phillips, Christa Krupski   +6 more
wiley   +1 more source

Effects of repetitive low-level blast exposure on visual system and ocular structures

Journal of Rehabilitation Research and Development, 2015
The purpose of this study was to determine whether repetitive exposure to low-level blasts during military breacher training produces acute and cumulative damage to the ocular tissues or visual system. The effects of low-level blast exposure on high-contrast visual acuity, contrast sensitivity, oculomotor function, color vision, visual field (VF ...
José E, Capó-Aponte, Gina M, Jurek, David V, Walsh, Leonard A, Temme, William A, Ahroon, Daniel W, Riggs   +5 more
openaire   +2 more sources

Experimental and numerical investigations of glass curtain walls subjected to low- level blast loads [PDF]

International Journal of Computational Methods and Experimental Measurements, 2015
A series of three full-scale, nearly-conventional, curtain wall specimens were blast tested in the open arena of the Infrastructure Security and Emergency Responder Research and Training (ISERRT) Facility in Gastonia, NC. The specimens were subjected to low-level blast loads produced from the detonation of high explosives.
Adam D. Ralston, David C. Weggel, Matthew J. Whelan, Hongbing Fang   +3 more
openaire   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

A Comprehensive Review of Experimental Rodent Models of Repeated Blast TBI

Frontiers in Neurology, 2019
We reviewed the relevant literature delineating advances in the development of the experimental models of repeated blast TBI (rbTBI). It appears this subject is a relatively unexplored area considering the first work published in 2007 and the bulk of ...
Maciej Skotak, Molly T. Townsend, Kakulavarapu V. Ramarao, Namas Chandra   +3 more
doaj   +1 more source

DNA Methylation Patterns of Chronic Explosive Breaching in U.S. Military Warfighters

Frontiers in Neurology, 2020
Background: Injuries from exposure to explosions rose dramatically during the Iraq and Afghanistan wars, which motivated investigation of blast-related neurotrauma.
Zhaoyu Wang, Caroline M. Wilson, Caroline M. Wilson, Yongchao Ge, Jeffrey Nemes, Christina LaValle, Angela Boutté, Walter Carr, Walter Carr, Gary Kamimori, Fatemeh Haghighi, Fatemeh Haghighi   +11 more
doaj   +1 more source

Blast-induced loss of GLT-1-expressing astrocytes.

, 2017
At 2 h following injury, sham control (A), low-blast (B), and high-blast (C) OHCs were stained using antibodies against GLT-1 (green), GFAP (gray), PI (red), and DAPI (blue).
Brandy V. Aperi (3815545), Anna P. Miller (3815539), Shekar N. Kurpad (2556643), Aleksandra Glavaski-Joksimovic (3815542), Alok S. Shah (729610), Brian D. Stemper (729612)   +5 more
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source