Results 271 to 280 of about 323,060 (314)
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On the metabolic conversion of human plasma very low density lipoprotein to low density lipoprotein
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1973Abstract The relationship of 125I-labelled apoproteins of very low density lipoprotein to that of other lipoproteins was studied in humans during steady-state conditions and following heparin injection. Heterogeneous metabolism of very low density lipo-protein apoproteins in normal individuals was apparent during steady-state conditions ...
Robert I. Levy +3 more
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Pharmacology & Therapeutics, 1997
Oxidation of low-density lipoprotein (LDL) may be implicated in the development of atherosclerotic disease. Oxidised LDL is taken up more readily by monocyte-derived macrophages than LDL. Antibodies to oxidised LDL are found in atherosclerotic lesions, Increased risk of ischaemic heart disease is associated with a preponderance of small dense LDL ...
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Oxidation of low-density lipoprotein (LDL) may be implicated in the development of atherosclerotic disease. Oxidised LDL is taken up more readily by monocyte-derived macrophages than LDL. Antibodies to oxidised LDL are found in atherosclerotic lesions, Increased risk of ischaemic heart disease is associated with a preponderance of small dense LDL ...
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Cytotoxic Effect of Low-Density Lipoproteins
Bulletin of Experimental Biology and Medicine, 2003The cytopathogenic effect of various modified lipoproteins on cultured peritoneal macrophages was studied in vitro. After minor peroxide modification lipoproteins induced apoptosis of macrophages. Immune complexes containing oxidized lipoproteins caused cell necrosis.
A. N. Voskan'yants +4 more
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Mild autoxidation of low density lipoproteins
Pharmaceutica Acta Helvetiae, 1996The autoxidation of low density lipoproteins was investigated in a closed system, with limited amount of oxygen. The concentrations of several components were monitored: oxygen, aldehydic oxidation products and alpha-tocopherol. The concentration of lipid radicals generated in the processes of lipid peroxidation was monitored by the EPR spin trapping ...
Tatjana Ukrainczyk +2 more
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Atherosclerosis, 1995
We have identified two familial defective apo B-100 (FDB) homozygotes by DNA sequencing and have measured affinity of low-density lipoproteins (LDL) and very-low-density lipoprotein (VLDL) remnants for the LDL receptor in vitro. The patients were a 66-year-old man with coronary heart disease (plasma cholesterol level, 9.5 mmol/l before treatment) and ...
John J. Gallagher, Nicolas B. Myant
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We have identified two familial defective apo B-100 (FDB) homozygotes by DNA sequencing and have measured affinity of low-density lipoproteins (LDL) and very-low-density lipoprotein (VLDL) remnants for the LDL receptor in vitro. The patients were a 66-year-old man with coronary heart disease (plasma cholesterol level, 9.5 mmol/l before treatment) and ...
John J. Gallagher, Nicolas B. Myant
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Inhibition of Low-Density Lipoprotein and High-Density Lipoprotein Oxidation by Raloxifene
Journal of Women's Health, 2004Raloxifene (RX), a selective estrogen receptor modulator (SERM), has demonstrated hypolipidemic and in vitro antioxidant properties. In the pathogenesis of atherosclerosis, the oxidative modification of low-density lipoprotein (LDL) is implicated to play a crucial role.In this study, we investigated the antioxidant properties of RX during in vitro LDL ...
Ulrike Resch +3 more
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Low-density Lipoproteins in Atherogenesis
2000It is well established that high levels of plasma cholesterol, particularly those associated with low-density lipoprotein (LDL), increase the risk of developing atherosclerosis. It is also clear that lowering plasma cholesterol levels can arrest or even reverse the progression of the disease [1,2].
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High-density lipoprotein inhibits the oxidative modification of low-density lipoprotein
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1990Oxidatively modified low-density lipoprotein (LDL), generated as a result of incubation of LDL with specific cells (e.g., endothelial cells, EC) or redox metals like copper, has been suggested to be an atherogenic form of LDL. Epidemiological evidence suggests that higher concentrations of plasma high-density lipoprotein (HDL) are protective against ...
Sampath Parthasarathy +2 more
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Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1991
We examined the uptake pathway of acetylated low-density lipoprotein and oxidatively modified LDL (oxidized LDL) in human umbilical vein endothelial cells in culture. Proteolytic degradation of 125I-labeled Ac-LDL or Ox-LDL in the confluent monolayer of human endothelial cells was time-dependent and showed saturation kinetics in the dose-response ...
Hidenori Arai +3 more
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We examined the uptake pathway of acetylated low-density lipoprotein and oxidatively modified LDL (oxidized LDL) in human umbilical vein endothelial cells in culture. Proteolytic degradation of 125I-labeled Ac-LDL or Ox-LDL in the confluent monolayer of human endothelial cells was time-dependent and showed saturation kinetics in the dose-response ...
Hidenori Arai +3 more
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Immunity to Low-Density Lipoprotein [PDF]
, 2011 Animal experiments, epidemiological studies and clinical investigations all show that high levels of plasma low-density lipoprotein (LDL) promote atherosclerotic cardiovascular disease [1]. LDL particles contain epitopes that trigger cellular and humoral immune responses. Autoimmunization during the course of atherosclerosis generates proinflammatory T
Göran K. Hansson, Göran K. Hansson
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