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Low‐Density Lipoprotein Receptor on Endothelium of Brain Capillaries
Journal of Neurochemistry, 1989 Abstract: The presence of lipoproteins, apolipoproteins, and their receptors in the brain could provide a system for cholesterol homeostasis, as they do in other tissues. This study was undertaken to determine whether plasma low‐density lipoprotein, the major carrier of cholesterol, is involved in the delivery of lipids through the blood‐brain barrier.
Méresse, Stéphane +3 more
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The low density lipoprotein receptor
Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes, 1989The study of familial hypercholesterolemia at the molecular level has led to its advancement from a clinical syndrome to a fascinating experimental system. FH was first described 50 years ago by Carl Müller who concluded that the disease produces high plasma cholesterol levels and myocardial infarctions in young people, and is transmitted as an ...
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Calcium Antagonists and Low Density Lipoprotein Receptors
Annals of the New York Academy of Sciences, 1988The effect of different calcium antagonists on receptor-mediated LDL catabolism by human cells in culture was investigated. The calcium antagonists have been recently classified in six types, based on their pharmacological activities. The three types selective for the slow calcium channels (types I, II, and III), and the nonselective type IV have been ...
Paoletti R1 +4 more
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Reconstitution of the low density lipoprotein receptor
Journal of Cellular Biochemistry, 1983AbstractThe receptor for low density lipoprotein was purified from bovine adrenal cortex in the presence of the nonionic detergent octylglucoside. Receptors were incorporated into the bilayer of egg phosphatidylcholine vesicles by a detergent‐dialysis method.
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An endothelial receptor for oxidized low-density lipoprotein
Nature, 1997Endothelial dysfunction or activation elicited by oxidatively modified low-density lipoprotein (Ox-LDL) has been implicated in the pathogenesis of atherosclerosis, characterized by intimal thickening and lipid deposition in the arteries. Ox-LDL and its lipid constituents impair endothelial production of nitric oxide, and induce the endothelial ...
T, Sawamura +10 more
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Receptor-mediated low-density lipoprotein catabolism
Klinische Wochenschrift, 1982Low-density lipoprotein (LDL) receptors are demonstrable in cultured fibroblasts from normal subjects but are decreased or absent in cells from patients with heterozygous or homozygous familial hypercholesterolaemia. In vivo receptor-mediated LDL catabolism, determined as the difference between the turnover rates of 125I-LDL and 131I-LDL coupled with ...
F A, Spengel, G R, Thompson
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Receptors for oxidized low density lipoprotein
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1999An increasing body of evidence indicates that oxidized low density lipoprotein (LDL) is involved in the pathogenesis of atherosclerosis. One of the first biologic actions of oxidized LDL to be identified in vitro was its ability to interact with the 'acetyl LDL receptor' discovered by Goldstein and Brown. Over the past decade, considerable progress has
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The Low-Density Lipoprotein Receptor
1987The low-density lipoprotein (LDL) receptor is a prototype for a class of cell surface receptors that bind lipoproteins and other circulating macromolecules and carry them into cells by receptor-mediated endocytosis. The human LDL receptor is a single-chain transmembrane glycoprotein of 839 amino acids.
Michael S. Brown, Joseph L. Goldstein
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