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Atherosclerosis: The low-density lipoprotein receptor hypothesis
Metabolism, 1977Abstract Recent biochemical, genetic, and ultrastructural studies have disclosed that non-hepatic human cells, such as fibroblasts, lymphocytes, and aortic smooth muscle cells, utilize a specific metabolic pathway, the low-density lipoprotein (LDL) pathway, to supply themselves with cholesterol.
J L, Goldstein, M S, Brown
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Scavenger receptors and oxidized low density lipoproteins
Clinica Chimica Acta, 1999Oxidized LDL has been shown to exhibit a number of potentially proatherogenic actions and properties, including receptor-mediated uptake and lipid accumulation within macrophages. It has been postulated that rapid, unregulated uptake of oxidatively modified LDL could account for the transformation of monocyte-derived macrophages to foam cells in ...
B S, Dhaliwal, U P, Steinbrecher
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Low-density lipoprotein receptor structure and folding
Cellular and Molecular Life Sciences, 2004The endoplasmic reticulum (ER) is a major cellular 'production factory' for many membrane and soluble proteins. A quality control system ensures that only correctly folded and assembled proteins leave the compartment. The low-density lipoprotein receptor (LDLR) is the prototype of a large family of structurally homologous cell surface receptors, which ...
J, Gent, I, Braakman
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THE MAMMALIAN LOW-DENSITY LIPOPROTEIN RECEPTOR FAMILY
Annual Review of Nutrition, 1999▪ Abstract The low-density lipoprotein (LDL) receptor (LDL-R) family consists of cell-surface receptors that recognize extracellular ligands and internalize them for degradation by lysosomes. The LDL-R is the prototype of this family, which also contains very-low-density lipoprotein receptors (VLDL-R), apolipoprotein E receptor 2, LRP, and megalin ...
M M, Hussain +2 more
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Genetics of the low density lipoprotein receptor:
Clinical Genetics, 1981Fibroblast association (plasma membrane binding plus intracellular accumulation) and degradation of radioiodinated low density lipoprotein (125I‐LDL) index plasma membrane LDL receptor activity. Cultured fibroblasts from 23 subjects affected with familial hypercholesterolemia (HC) and from 95 subjects without HC (non‐HCs) were tested for 125I‐LDL ...
K, Maartmann-Moe +3 more
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Receptor-independent low-density lipoprotein catabolism
1986Cultured cells, animal models, and man all possess mechanisms for LDL degradation that do not require the agency of the high-affinity receptor. In healthy individuals their functional significance can be determined using LDL which has been modified by specific chemical reactions designed to inhibit it receptor binding.
J, Shepherd, C J, Packard
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Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1986
The role of the cellular receptor for the low-density lipoproteins (LDL) in cholesterol transport was initially defined through the study of nonhepatic cells in vitro. Since the liver is central in plasma lipoprotein metabolism, an investigation of hepatic lipoprotein receptors is important for understanding normal lipoprotein transport.
J M, Hoeg +5 more
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The role of the cellular receptor for the low-density lipoproteins (LDL) in cholesterol transport was initially defined through the study of nonhepatic cells in vitro. Since the liver is central in plasma lipoprotein metabolism, an investigation of hepatic lipoprotein receptors is important for understanding normal lipoprotein transport.
J M, Hoeg +5 more
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International Journal of Biochemistry, 1983
The role of apo-low density lipoprotein in the regulation of low density lipoprotein receptor synthesis was studied. Fibroblasts preincubated in the presence of a cholesterol-free low density lipoprotein preparation showed an increase of 50% in receptor activity.
A M, Leung, W K, Cheung, W K, Ho
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The role of apo-low density lipoprotein in the regulation of low density lipoprotein receptor synthesis was studied. Fibroblasts preincubated in the presence of a cholesterol-free low density lipoprotein preparation showed an increase of 50% in receptor activity.
A M, Leung, W K, Cheung, W K, Ho
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Low-density lipoprotein binding assay using the calf adrenocortical low-density lipoprotein receptor
Clinical Biochemistry, 1994The low-density lipoprotein (LDL) receptor was purified to a semipure solubilized form from calf adrenocortical tissue. This receptor was found to be a suitable substitute for the human LDL receptor for studying human LDL binding. The apparent dissociation constant of the receptor from calf adrenocortical cells, using human LDL as the ligand, was found
P, Catomeris, R J, Thibert, T F, Draisey
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European Journal of Biochemistry, 1983
Incubation of human low-density lipoprotein (LDL) with glucose results in a nonenzymatic formation of a Schiff base between the monosaccharide and lysyl residues of apolipoprotein B. Increasing the percentage of lysyl residues of apolipoprotein B modified by glycosylation decreases the fractional catabolic rate of the glycosylated LDL, and decreases ...
J, Sasaki, T, Okamura, G L, Cottam
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Incubation of human low-density lipoprotein (LDL) with glucose results in a nonenzymatic formation of a Schiff base between the monosaccharide and lysyl residues of apolipoprotein B. Increasing the percentage of lysyl residues of apolipoprotein B modified by glycosylation decreases the fractional catabolic rate of the glycosylated LDL, and decreases ...
J, Sasaki, T, Okamura, G L, Cottam
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