Results 101 to 110 of about 1,790,903 (284)

Subharmonic solutions for nonlinear second order equations in presence of lower and upper solutions

Discrete & Continuous Dynamical Systems - A, 2013
We study the problem of existence and multiplicity of subharmonic solutions for a second order nonlinear ODE in presence of lower and upper solutions. We show how such additional information can be used to obtain more precise multiplicity results.
BOSCAGGIN, Alberto, ZANOLIN F.
openaire   +3 more sources

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Existence of stable periodic solutions for quasilinear parabolic problems in the presence of well-ordered lower and upper-solutions

Electronic Journal of Differential Equations, 2002
We present existence and stability results for periodic solutions of quasilinear parabolic equation related to Leray-Lions's type operators. To prove existence and localization, we use the penalty method; while for stability we use an approximation ...
Abderrahmane El Hachimi, Abdelilah Lamrani Alaoui   +1 more
doaj  

Stability of periodic solutions of first-order difference equations lying between lower and upper solutions

Advances in Difference Equations, 2005
We prove that if there exists α≤β, a pair of lower and upper solutions of the first-order discrete periodic problem Δu(n)=f(n,u(n));n∈IN≡{0,…,N−1},u(0)=u(N), with f a continuous N-periodic function in its first variable ...
Dolores Rodríguez-Vivero, Victoria Otero-Espinar, Alberto Cabada   +2 more
doaj   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Monotone iterative method and regular singular nonlinear BVP in the presence of reverse ordered upper and lower solutions

Electronic Journal of Differential Equations, 2012
Monotone iterative technique is employed for studying the existence of solutions to the second-order nonlinear singular boundary value problem $$ -ig(p(x)y'(x)ig)'+p(x)fig(x,y(x),p(x)y'(x)ig)=0 $$ for $0<x<1$ and $y'(0)=y'(1)=0$. Here $p(0)=0$
Amit K. Verma
doaj