Results 81 to 90 of about 327,898 (294)
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Existence and blow-up of solutions for a semilinear filtration problem
Electronic Journal of Differential Equations, 2013 We first examine the existence and uniqueness of local solutions to the semilinear filtration equation $u_t=Delta K(u)+lambda f(u)$, for $lambda>0$, with initial data $u_0geq 0$ and appropriate boundary conditions. Our main result is the proof of blow-
Evangelos A. Latos +1 more
doaj
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Existence of three solutions for a higher-order boundary-value problem
Electronic Journal of Differential Equations, 2009 We consider a higher-order multi-point boundary-value problem with a nonlinear boundary condition. Sufficient conditions are obtained for the existence of three solutions.
John R. Graef, Lingju Kong, Qingkai Kong
doaj
Limit periodic upper and lower solutions in a generic sense
, 2018 The method of upper and lower solutions is a main tool to prove the existence of periodic solutions to periodic differential equations. It is known that, in general, the method does not extend to the almost periodic case.
M. Tarallo, Z. Zhou
core +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Upper and lower solutions for a second-order three-point singular boundary-value problem
Electronic Journal of Differential Equations, 2009 We study the singular boundary-value problem $$displaylines{ u''+ q(t)g(t,u)=0,quad t in (0,1),; eta in (0,1),;gamma >0cr u(0)=0, quad u(1)=gamma u(eta),.
Qiumei Zhang +3 more
doaj
The method of lower and upper solutions for fourth order equations with the Navier condition
Boundary Value Problems, 2017 The aim of this paper is to explore the method of lower and upper solutions in order to give some existence results for equations of the form y ( 4 ) ( x ) + ( k 1 + k 2 ) y ″ ( x ) + k 1 k 2 y ( x ) = f ( x , y ( x ) ) , x ∈ ( 0 , 1 ) , $$y^{(4)}(x)+(k_{
Ruyun Ma, Jinxiang Wang, Dongliang Yan
doaj +1 more source