Results 61 to 70 of about 318,439 (262)
Existence and blow-up of solutions for a semilinear filtration problem
Electronic Journal of Differential Equations, 2013 We first examine the existence and uniqueness of local solutions to the semilinear filtration equation $u_t=Delta K(u)+lambda f(u)$, for $lambda>0$, with initial data $u_0geq 0$ and appropriate boundary conditions. Our main result is the proof of blow-
Evangelos A. Latos +1 more
doaj
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Existence of three solutions for a higher-order boundary-value problem
Electronic Journal of Differential Equations, 2009 We consider a higher-order multi-point boundary-value problem with a nonlinear boundary condition. Sufficient conditions are obtained for the existence of three solutions.
John R. Graef, Lingju Kong, Qingkai Kong
doaj
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Upper and lower solutions for a second-order three-point singular boundary-value problem
Electronic Journal of Differential Equations, 2009 We study the singular boundary-value problem $$displaylines{ u''+ q(t)g(t,u)=0,quad t in (0,1),; eta in (0,1),;gamma >0cr u(0)=0, quad u(1)=gamma u(eta),.
Qiumei Zhang +3 more
doaj
The method of lower and upper solutions for fourth order equations with the Navier condition
Boundary Value Problems, 2017 The aim of this paper is to explore the method of lower and upper solutions in order to give some existence results for equations of the form y ( 4 ) ( x ) + ( k 1 + k 2 ) y ″ ( x ) + k 1 k 2 y ( x ) = f ( x , y ( x ) ) , x ∈ ( 0 , 1 ) , $$y^{(4)}(x)+(k_{
Ruyun Ma, Jinxiang Wang, Dongliang Yan
doaj +1 more source
Upper and lower solutions satisfying the inverse inequality [PDF]
Annales Polonici Mathematici, 1997 Summary: We consider multipoint and two-point BVPs for second order ordinary differential equations with a Carathéodory right hand side. We prove the existence of solutions provided there exist upper and lower solutions of the BVP and the upper solution is less than the lower one.
openaire +2 more sources
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source