Results 101 to 110 of about 3,701,882 (277)

Lower bound for mr (2,41) and related code [PDF]

BIO Web of Conferences
A (k, n) - arc is a set of k points of a projective plane such that some n, but no n+1 of them, are collinear. The maximum size of a (k, n) - arc in PG(2 q) is denoted by mr(2, q).
Yahya Hanan Maysar Sabih, Yahya Nada Yassen Kasm   +1 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

How Low Can You Go? New Evidence Supports No Lower Bound to Low-Density Lipoprotein Cholesterol Level in Secondary Prevention. [PDF]

Circulation, 2023
Rodriguez F, Khera A.
europepmc   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Lower Bound for the Class Number of Q49m2+4m

International Journal of Mathematics and Mathematical Sciences
In this paper, we obtain an explicit lower bound for the class number of real quadratic field QD, where D=49m2+4m is a square-free positive integer and m≡2 (mod 7) be an odd positive integer.
Rahaf Jihny, Boushra Darrag, Ahmad Issa
doaj   +1 more source

Constructing Grith Eight GC-LDPC Codes Based on the GCD FLRM Matrix with a New Lower Bound. [PDF]

Sensors (Basel), 2022
Zhu K, Yang H.
europepmc   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Matrix-Wigner Distribution

Fractal and Fractional
In order to achieve time–frequency superresolution in comparison to the conventional Wigner distribution (WD), this study generalizes the well-known τ-Wigner distribution (τ-WD) with only one parameter τ to the multiple-parameter matrix-Wigner ...
Long Wang, Manjun Cui, Ze Qin, Zhichao Zhang, Jianwei Zhang   +4 more
doaj   +1 more source

Comparison of an improved self-consistent lower bound theory with Lehmann's method for low-lying eigenvalues. [PDF]

Sci Rep, 2021
Ronto M, Pollak E, Martinazzo R.
europepmc   +1 more source