Results 91 to 100 of about 1,776,297 (283)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

モノアザテトラチオエーテルを含有する温度感応性高分子による銀(I)イオンの抽出挙動 [PDF]

, 2008
A novel temperature sensitive extraction copolymers, 9-aza-3,6,12,15-tetrathiaheptadecane-derivatized N-isopropylacrylamide polymer (ATH-NIPAAm), has been synthesized in various incorporation ratios.
Kenji Chayama, Satoshi IWATSUKI, Yoshiaki Morita, 岩月 聡史, 森田 吉亮, 茶山 健二   +5 more
core   +1 more source

Responsive glyco-poly(2-oxazoline)s: synthesis, cloud point tuning, and lectin binding [PDF]

, 2011
A new sugar-substituted 2-oxazoline monomer was prepared using the copper-catalyzed alkyne-azide cycloaddition (CuAAC) reaction. Its copolymerization with 2-ethyl-2-oxazoline as well as 2-(dec-9-enyl)-2-oxazoline, yielding well-defined copolymers with ...
Adams N., Ambrosi M., Aoi K., Aoi K., Aoi K., Aoi K., Bassiri T. G., Bloksma M. M., Campos L. M., Cesana S., Christine Weber, Christova D., Collins B. E., Cortez M. A., Diehl C., Dimick S. M., Gabius H. J., Hoogenboom R., Hoogenboom R., Huber S., Kagiya T., Kempe K., Kempe K., Knop K., Kobayashi S., Kobayashi S., Kobayashi S., Kristian Kempe, Krzysztof Babiuch, Lambermont-Thijs H. M. L., Lin P. Y., Lundquist J. J., Michael Gottschaldt, Mikata Y., Narain R., Richard Hoogenboom, Saegusa T., Saegusa T., Seeliger W., Slavin S., Stillman B. N., Takasu A., Taubmann C., Ting S. R. S., Tomalia D. A., Tsutsumiuchi K., Ulrich S. Schubert, Vazquez-Dorbatt V., Weber C., Wiesbrock F., Wiesbrock F., Witte H.   +51 more
core   +2 more sources

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Advances in thermo-responsive polymers exhibiting upper critical solution temperature (UCST)

eXPRESS Polymer Letters, 2019
Immense work has been conducted in the field of thermoresponsive polymers specifically of lower critical solution temperature (LCST) type, but upper critical solution temperature (UCST) type polymers remain a significantly unexplored domain.
K. K. Bansal, P. K. Upadhyay, G. K. Saraogi, A. Rosling, J. M. Rosenholm   +4 more
doaj   +1 more source

Design of thermoresponsive polymeric gates with opposite controlled release behaviors [PDF]

, 2016
Stimuli-responsive devices are novel tools widely studied in the nanomedicine research field. In this work, magnetic-responsive mesoporous silica nanoparticles (MMSNs) were coated with an engineered thermoresponsive co-polymer. Magnetic cores are used as
Arcos Navarrete, Daniel, Baeza, Alejandro, Guisasola, Eduardo, Talelli, Marina, Vallet Regí, María   +4 more
core   +2 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Phase Behavior and Heat Capacity of {DPnP + Water} Mixtures at the Temperature Range of 273.15–338.15 K

Journal of Chemistry, 2015
The differential scanning calorimetry method (DSC) was used to examine the miscibility in the {dipropylene glycol propyl ether (DPnP) + water} system.
Mariola Tkaczyk, Henryk Piekarski, Paweł Góralski   +2 more
doaj   +1 more source

Condensate statistics in interacting Bose gases: exact results

, 2002
Recently, a Quantum Monte Carlo method alternative to the Path Integral Monte Carlo method was developed for the numerical solution of the N-boson problem; it is based on the stochastic evolution of classical fields.
D. F. Walls, D. M. Ceperley, Iacopo Carusotto, M. Wilkens, Yvan Castin   +4 more
core   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source