Results 71 to 80 of about 1,978,744 (337)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Branched Copolymer Surfactants as Versatile Templates for Responsive Emulsifiers with Bespoke Temperature‐Triggered Emulsion‐Breaking or Gelation

Advanced Materials Interfaces
It has been found that the thermoresponsive behavior of emulsions stabilized by block copolymer surfactants (BCSs) can induce either gelation or emulsion break‐up with mild temperature changes.
Abhishek Rajbanshi, Marcelo Alves da Silva, Niamh Haslett, Philippa Cranwell, Neil Cunningham, Najet Mahmoudi, Darragh Murnane, Ewa Pavlova, Miroslav Slouf, Cecile Dreiss, Michael Cook   +10 more
doaj   +1 more source

Соціальна культура громадян - найкращий антикризовий засіб [PDF]

, 2009
An anthracene-functionalized thermosensitive block copolymer was synthesized, which formed micelles by heating its aqueous solution above the lower critical solution temperature (LCST). The micelles were subsequently crosslinked by UV illumination at 365
Cardoso, Renata M., Hennink, Wim E., Shi, Yang, Van Nostrum, Cornelus F.   +3 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Effect of Gold Nanoparticle Size on Regulated Catalytic Activity of Temperature-Responsive Polymer−Gold Nanoparticle Hybrid Microgels

Gels
Gold nanoparticles (AuNPs) possess attractive electronic, optical, and catalytic properties, enabling many potential applications. Poly(N-isopropyl acrylamide) (PNIPAAm) is a temperature-responsive polymer that changes its hydrophilicity upon a slight ...
Palida Pongsanon, Akifumi Kawamura, Hideya Kawasaki, Takashi Miyata   +3 more
doaj   +1 more source

LCST phase behavior of benzo-21-crown-7 with different alkyl chains

Beilstein Journal of Organic Chemistry, 2019
The introduction of hydrophobic units into crown ethers can dramatically decrease the critical transition temperature of LCST and realize macroscopic phase separation at low to moderate temperature and concentration.
Yan Deng, Xing Li, Qiao Zhang, Zheng Luo, Chengyou Han, Shengyi Dong   +5 more
doaj   +1 more source

The Removal of Hydrophobic Matter from Thermosensitive Poly[oligo(ethylene glycol) Monomethyl Ether Acrylate] Gel Adsorbent in Alcohol–Water Mixtures

Gels, 2022
A thermosensitive gel that exhibits lower critical solution temperature (LCST) becomes hydrophilic at low temperatures and hydrophobic at high temperatures in water.
Syed Ragib Safi, Toshiki Kaneko, Katsuhiro Nakahara, Takehiko Gotoh, Takashi Iizawa   +4 more
doaj   +1 more source

Synthesis of Amphiphilic Three-Armed Star Random Copolymers via Living Radical Polymerization and their Unimolecular Folding Properties in Water [PDF]

, 2015
Amphiphilic three-armed star random copolymers were synthesized by ruthenium-catalyzed living radical copolymerization of hydrophilic poly(ethylene glycol) methyl ether methacrylate (PEGMA) and hydrophobic dodecyl methacrylate (DMA).
Matsumoto, Kazuma, Sawamoto, Mitsuo, Sugita, Takanori, Terashima, Takaya   +3 more
core   +1 more source

Hydrophobic Interaction Model for Upper and Lower Critical Solution Temperatures [PDF]

Macromolecules, 2003
11 pages, 7 figures, to be published in ...
Moelbert, Susanne, Rios, Paolo De Los
openaire   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source