Results 81 to 90 of about 911,610 (308)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Collaboration between subject teachers and special education teachers in Finnish lower secondary schools

Education Inquiry
It has been argued that successful teacher collaboration is challenging to implement in a secondary school context, where teaching is based on subjects.
Ninnu Kotilainen, Riikka Sirkko, Marjatta Takala   +2 more
doaj   +1 more source

The Relative Age Effect, Height and Weight Characteristics among Lower and Upper Secondary School Athletes in Norway and Sweden

Sports, 2017
The relative age effect (RAE) has been found among youth elite athletes within a range of sports. However, the RAE has been studied to a lesser degree among youth non-elite athletes, and even less among school pupils attending sport specialisation ...
Stig Arve Sæther, Tomas Peterson, Vazjwar Matin   +2 more
doaj   +1 more source

Vocational Schooling, Labor Market Outcomes, and College Entry [PDF]

This paper examines the differentiated outcomes of vocational and general secondary academic education, particularly in terms of employment opportunities, labor market earnings, and access to tertiary education in Indonesia. With data from a panel of two
Chen, Dandan
core  

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Fast food restaurant locations according to socioeconomic disadvantage, urban–regional locality, and schools within Victoria, Australia

SSM: Population Health, 2016
Features of the built environment provide opportunities to engage in both healthy and unhealthy behaviours. Access to a high number of fast food restaurants may encourage greater consumption of fast food products.
Lukar E. Thornton, Karen E. Lamb, Kylie Ball   +2 more
doaj   +1 more source

Regula falsi in lower secondary school education

Teaching Mathematics and Computer Science, 2016
The aim of this paper is to offer some possible ways of solving word problems in lower secondary school education. Many studies have shown that pupils in lower secondary school education (age 13-14) encounter difficulties with learning algebra. Therefore they mainly use arithmetical and numerical checking methods to solve word problems.
openaire   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

The impact of private provision of public education : empirical evidence from Bogota's concession schools [PDF]

In 1999 the city of Bogota, Colombia launched the concession school program designed to broaden the coverage and quality of basic education. It consists of a contract between a group of private schools and the public educational system such that private ...
Barrera-Osorio, Felipe
core  

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source