Results 51 to 60 of about 35,598 (260)

ATTITUDE TOWARDS BORDER TOURISM AND ITS RELATIONSHIP WITH VISITOR SATISFACTION AND LOYALTY [PDF]

open access: yesGeo Journal of Tourism and Geosites, 2019
This study proposes new knowledge about tourism developed in border areas. In this study, structural equations models based on variance are applied, with a sample of 583 tourists.
Salvador MORAL-CUADRA   +2 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

open access: yesMolecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck   +12 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Analyzing the Influence of Service Quality towards the Brand Image, Preceived Value, and Brand Loyalty of The Costumers of Heritage Hotel in Malang

open access: yesJournal of Economics, Business & Accountancy Ventura, 2018
Service quality in heritage hotel in the Malang city and brand loyalty have an important role to affect the guests to stay at the hotel, by considering competition in modern time currently. The purpose of this research is to analyze the effect of service
Muhammad Iskandar Sjah
doaj   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

open access: yesMolecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad   +35 more
wiley   +1 more source

Interaction of Employee Loyalty and Customer Loyalty in the Service Industry

open access: yesتحقیقات بازار یابی نوین, 2011
The subject of customer loyalty is a focal concern of marketers who seek to identify its antecedents and casual structure with the aim of better understanding of its relationship with employee loyalty, particularly in the service sector.
Manijeh Gharacheh, Monireh Dabooeian
doaj   +2 more sources

Are Immigrants Disloyal? The Case of Mexicans in the U.S.

open access: yesEuropean Journal of American Studies, 2009
This article analyzes the concept of political loyalty in the context of mass migration flows to the U.S. After exploring the evolving notion of political loyalty, it provides a brief historical background of concerns about the political disloyalty of ...
Krystof Kozak
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Linking indirect compensation to behavioral loyalty: attitudinal loyalty and personal job satisfaction as key drivers

open access: yesCogent Business & Management
This study investigated the impact of indirect compensation on teachers’ behavioral loyalty in vocational colleges in Guiyang City, Guizhou Province, China, and also examined the impact of attitudinal loyalty as a mediator between indirect compensation ...
Kanyanit Wichianrat   +3 more
doaj   +1 more source

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