Results 51 to 60 of about 299,336 (310)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
How to Design International Loyalty Programs [PDF]
, 2009 Despite the growing importance of customer loyalty programs in marketing practice, research about international loyalty programs is few and far between. Especially the issue of whether loyalty programs can be standardized across countries has not been
Heß, Silke C. +2 more
core
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Marketing strategies for building customer loyalty in hotels in João Pessoa-PB [PDF]
GeoStudiesThe hotel industry is facing an increasingly competitive market in which customer loyalty is crucial to gaining a competitive edge and increasing profitability. Loyalty programs are valuable strategies for customer retention, especially in an environment
Ramom Santos Custódio +4 more
doaj +3 more sources
Make me special: Gender differences in consumers’ responses to loyalty programs [PDF]
, 2012 Current literature on loyalty programs emphasizes the importance of psychological rewards and special treatment. However, it is not clear if male and female customers respond to these incentives in a similar way.
Melnyk, V. (Valentina) +1 more
core +5 more sources
Loyalty Program Assessment. KPI-Based Evaluation of Customer Loyalty Programs
, 2022 Loyalty programs are booming, but the evidence of their effectiveness is controversial. Many companies are unsure whether and how to use loyalty programs profitably. Measuring the effectiveness of a customer loyalty program is important, but not easy.
openaire +2 more sources
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Loyalty Program Liabilities and Point Values [PDF]
Manufacturing & Service Operations Management, 2017 Problem definition: Loyalty programs (LPs) introduce a new currency—the points—through which customers transact with firms. Such points represent a promise for future service, and their monetary value thus counts as a liability on the issuing firms’ balance sheets.
So Yeon Chun +2 more
openaire +3 more sources