Results 231 to 240 of about 98,340 (281)
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Prostaglandins & Other Lipid Mediators, 2001
Lysophosphatidic acid (LPA) is a growth factor-like lipid that produces many cellular responses. These responses, including actin cytoskeletal rearrangements, cell proliferation and inhibition of gap junction communication, have been documented in many cell types over the last 2 decades.
N, Fukushima, J, Chun
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Lysophosphatidic acid (LPA) is a growth factor-like lipid that produces many cellular responses. These responses, including actin cytoskeletal rearrangements, cell proliferation and inhibition of gap junction communication, have been documented in many cell types over the last 2 decades.
N, Fukushima, J, Chun
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LPA receptor 2 mediates LPA-induced endometrial cancer invasion
Gynecologic Oncology, 2009We have previously shown that lysophosphatidic acid (LPA) promotes the ovarian cancer metastatic cascade. In this study, we evaluated the role of LPA on endometrial cancer invasion.Transient mRNA knockdown was accomplished using pre-designed siRNA duplexes against LPA receptor 2 (LPA2) and human matrix metalloproteinase-7 (MMP-7).
Joanie Mayer, Hope +6 more
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Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1993
Tangier disease (TD) is characterized by extremely low plasma levels of HDL, apoA-I and apoA-II due to very rapid catabolism. However, the risk of premature coronary heart disease (CHD) is not markedly increased in TD. In order to gain insight into reverse cholesterol transport in TD, we isolated LpA-I, LpA-I:A-II, LpA-II and LpA-IV particles from ...
P, Duchateau +7 more
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Tangier disease (TD) is characterized by extremely low plasma levels of HDL, apoA-I and apoA-II due to very rapid catabolism. However, the risk of premature coronary heart disease (CHD) is not markedly increased in TD. In order to gain insight into reverse cholesterol transport in TD, we isolated LpA-I, LpA-I:A-II, LpA-II and LpA-IV particles from ...
P, Duchateau +7 more
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LPA modulates monocyte migration directly and via LPA-stimulated endothelial cells
American Journal of Physiology-Cell Physiology, 2008Lysophosphatidic acid (LPA) is a bioactive lysophospholipid ligand present in oxidized low-density lipoprotein. The effects of LPA were investigated, first separately on endothelial cells (EC) and monocytes. Using Ki16425 (an LPA1 and LPA3 receptor antagonist), GW9662 [a peroxisome proliferator-activator receptor (PPARγ) antagonist], and pertussis ...
Gustin, Cindy +2 more
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Science Signaling, 2011
Binding of the enzyme that synthesizes lysophosphatidic acid to integrins allows the production of this signaling molecule at its site of action.
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Binding of the enzyme that synthesizes lysophosphatidic acid to integrins allows the production of this signaling molecule at its site of action.
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LPA in neural cell development
Journal of Cellular Biochemistry, 2004AbstractLysophosphatidic acid (LPA) elicits diverse cellular responses through cell surface LPA receptors in nervous system‐derived cells and cell lines. The developing nervous system is one of the major loci for LPA receptor expression. Recent studies have also revealed that metabolic pathways of LPA are present in the nervous system.
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2009
The LPA accuracy is characterized by an error defined as the The analysis produced in the previous chapters concerns some aspects of the accuracy of the LPA operators. It has been proved that, as the sampling interval approaches zero, the discrete estimators can be replaced by corresponding integral ones.
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The LPA accuracy is characterized by an error defined as the The analysis produced in the previous chapters concerns some aspects of the accuracy of the LPA operators. It has been proved that, as the sampling interval approaches zero, the discrete estimators can be replaced by corresponding integral ones.
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