Results 21 to 30 of about 113,253 (324)

MAPK signaling determines lysophosphatidic acid (LPA)-induced inflammation in microglia

Journal of Neuroinflammation, 2020
Background In the extracellular environment, lysophosphatidic acid (LPA) species are generated via autotaxin (ATX)-mediated hydrolysis of lysophospholipid precursors.
I. Plastira, E. Bernhart, Lisha Joshi, C. N. Koyani, H. Strohmaier, H. Reicher, E. Malle, W. Sattler   +7 more
semanticscholar   +1 more source

Qui cause ? Qui dose ? Qui ose ?. À l’infini poème apporter une fin

Interfaces Numériques, 2022
Situant son propos dans l’espace théorique de « l’énonciation éditoriale » et du « numérique comme écriture », l’auteur interroge les paradigmes de la pensée linguistique et statistique qui président à la constitution des algorithmes de recherche dédiés ...
Emmanuël Souchier, Joanna Pomian
doaj   +1 more source

A comparison of experimental methods for measuring water permeability of porous building rocks

Materiales de Construccion, 2014
This paper compares different experimental methods for measuring water permeability in 17 different porous building rocks. Both commercial apparatus and specially made designed permeameters are used for characterising intrinsic permeability and hydraulic
S. Galvan, C. Pla, N. Cueto, J. Martínez-Martínez, M. A. García-del-Cura, D. Benavente   +5 more
doaj   +1 more source

Low phytic acid Crops: Observations Based On Four Decades of Research

Plants, 2020
The low phytic acid (lpa), or “low-phytate” seed trait can provide numerous potential benefits to the nutritional quality of foods and feeds and to the sustainability of agricultural production.
Victor Raboy
doaj   +1 more source

Estimation radius regression in PLIC-VOF method for droplet evaporation

Partial Differential Equations in Applied Mathematics, 2022
Heat & fluid flow conservation equations of carburant liquid droplet are solved by a semi-implicit method of the Volume Of Fluid (VOF) scheme. A new technique of the droplet radius regression estimation based on the Piece-wise Linear Interface ...
Jean Nahed, Joseph Dgheim
doaj   +1 more source

tidyLPA: An R Package to Easily Carry Out Latent Profile Analysis (LPA) Using Open-Source or Commercial Software

Journal of Open Source Software, 2018
Researchers are often interested in identifying homogeneous subgroups within heterogeneous samples on the basis of a set of measures, such as profiles of individuals’ motivation (i.e., their values, competence beliefs, and achievement goals).
J. Rosenberg, Patrick N. Beymer, Daniel Anderson, Jennifer A. Schmidt   +3 more
semanticscholar   +1 more source

The Agpat4/LPA axis in colorectal cancer cells regulates antitumor responses via p38/p65 signaling in macrophages

Signal Transduction and Targeted Therapy, 2020
Lipid metabolic reprogramming plays an essential role in regulating the progression of colorectal cancer (CRC). However, the effect of lysophosphatidic acid (LPA) metabolism on CRC development is incompletely characterized.
Dapeng Zhang, Rongchen Shi, W. Xiang, Xia Kang, Bo Tang, Chuan Li, Linfeng Gao, Xuan Zhang, Lili Zhang, R. Dai, Hongming Miao   +10 more
semanticscholar   +1 more source

Association of LPA Variants With Risk of Coronary Disease and the Implications for Lipoprotein(a)-Lowering Therapies: A Mendelian Randomization Analysis

JAMA cardiology, 2018
Importance Human genetic studies have indicated that plasma lipoprotein(a) (Lp[a]) is causally associated with the risk of coronary heart disease (CHD), but randomized trials of several therapies that reduce Lp(a) levels by 25% to 35% have not provided ...
S. Burgess, B. Ference, James R. Staley, Daniel F. Freitag, AmyM. Mason, S. F. Nielsen, P. Willeit, Robin Young, P. Surendran, Savita Karthikeyan, Thomas R. Bolton, J. Peters, P. Kamstrup, A. Tybjærg-Hansen, M. Benn, A. Langsted, P. Schnohr, S. Vedel-Krogh, C. Kobylecki, I. Ford, C. Packard, S. Trompet, J. Jukema, N. Sattar, E. Angelantonio, D. Saleheen, J. Howson, B. Nordestgaard, A. Butterworth   +28 more
semanticscholar   +1 more source

Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA

Nature Communications, 2016
Genome-wide association studies have identified numerous loci linked with complex diseases, for which the molecular mechanisms remain largely unclear. Comprehensive molecular profiling of circulating metabolites captures highly heritable traits, which ...
J. Kettunen, A. Demirkan, A. Demirkan, P. Würtz, H. Draisma, T. Haller, R. Rawal, A. Vaarhorst, A. Kangas, L. Lyytikäinen, M. Pirinen, R. Pool, Antti-Pekka Sarin, Antti-Pekka Sarin, P. Soininen, P. Soininen, T. Tukiainen, Qin Wang, Qin Wang, M. Tiainen, M. Tiainen, Tuulia Tynkkynen, Tuulia Tynkkynen, N. Amin, T. Zeller, M. Beekman, J. Deelen, K. V. Dijk, T. Esko, J. Hottenga, E. M. Leeuwen, T. Lehtimäki, E. Mihailov, R. rose, R. rose, A. Craen, C. Gieger, M. Kähönen, M. Perola, M. Perola, M. Perola, S. Blankenberg, M. Savolainen, M. Savolainen, A. Verhoeven, J. Viikari, G. Willemsen, D. Boomsma, C. Duijn, J. Eriksson, J. Eriksson, A. Jula, M. Järvelin, J. Kaprio, J. Kaprio, A. Metspalu, O. Raitakari, O. Raitakari, V. Salomaa, P. Slagboom, M. Waldenberger, S. Ripatti, M. Ala-Korpela   +62 more
semanticscholar   +1 more source

Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries. [PDF]

, 2018
Lipoprotein(a), Lp(a), is a modified low-density lipoprotein particle that contains apolipoprotein(a), encoded by LPA, and is a highly heritable, causal risk factor for cardiovascular diseases that varies in concentrations across ancestries. Here, we use
Alver, Maris, Bloom, Jonathan, Budoff, Matthew, Chaffin, Mark, Correa, Adolfo, Cupples, L Adrienne, Daly, Mark J, Engreitz, Jesse, Ernst, Jason, Esko, Tonu, Fu, Mao, Ganna, Andrea, Handsaker, Robert E, Johnson, W Craig, Kathiresan, Sekar, Kellis, Manolis, Manichaikul, Ani, McCarroll, Steven, Metspalu, Andres, Mitchell, Braxton D, Natarajan, Pradeep, Neale, Benjamin M, NHLBI TOPMed Lipids Working Group, Peloso, Gina M, Post, Wendy, Poterba, Timothy, Rich, Stephen S, Ripatti, Samuli, Rotter, Jerome I, Ruotsalainen, Sanni, Ryan, Kathleen A, Salomaa, Veikko, Seed, Cotton, Surakka, Ida, Tsai, Michael, Vasan, Ramachandran S, Wilson, James G, Yang, Chaojie, Zekavat, Seyedeh M   +38 more
core   +1 more source