Results 181 to 190 of about 16,257 (211)
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Regulation of Lrp6 phosphorylation
Cellular and Molecular Life Sciences, 2010The Wnt/beta-catenin signaling pathway plays important roles in embryonic development and tissue homeostasis, and is implicated in human disease. Wnts transduce signals via transmembrane receptors of the Frizzled (Fzd/Fz) family and the low density lipoprotein receptor-related protein 5/6 (Lrp5/6).
Christof Niehrs
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Wnt Induces LRP6 Signalosomes and Promotes Dishevelled-Dependent LRP6 Phosphorylation
Science, 2007Multiple signaling pathways, including Wnt signaling, participate in animal development, stem cell biology, and human cancer. Although many components of the Wnt pathway have been identified, unresolved questions remain as to the mechanism by which Wnt binding to its receptors Frizzled and Low-density lipoprotein receptor–related protein 6 (LRP6 ...
Josipa, Bilic +6 more
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β-Catenin-Independent Roles of Wnt/LRP6 Signaling
Trends in Cell Biology, 2016Wnt/LRP6 signaling is best known for the β-catenin-dependent regulation of target genes. However, pathway branches have recently emerged, including Wnt/STOP signaling, which act independently of β-catenin and transcription. We review here the molecular mechanisms underlying β-catenin-independent Wnt/LRP6 signaling cascades and their implications for ...
Sergio Perez Acebron, Christof Niehrs
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Kremen2 modulates Dickkopf2 activity during Wnt/lRP6 signaling
Gene, 2003Dickkopf1 (Dkk1) is a secreted antagonist of the Wnt/beta-catenin signaling pathway that acts by direct binding to and inhibiting the Wnt co-receptor LRP6. The related Dkk2, however, can function either as LRP6 agonist or antagonist, depending on the cellular context, suggesting that its activity is modulated by unknown co-factors.
Bingyu, Mao, Christof, Niehrs
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Antagonists of LRP6 regulate PTH‐induced cAMP generation
Annals of the New York Academy of Sciences, 2011LRP6 is a common coreceoptor for different G protein‐coupled seven‐transmembrane receptors in production of cAMP. Extracelluar proteins sclerostin and DKK1, initially identified as antagonists for Wnt signaling by binding to LRP6, are negative regulators for bone formation.
Chenhui, Shi +5 more
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Science's STKE, 2005
Wnt stimulates the stabilization of β-catenin through interactions with a receptor complex composed of the seven-transmembrane Frizzled and the single-transmembrane low-density lipoprotein receptor-related protein 5 or 6 (LRP5/6). In the absence of Wnt, dual phosphorylation of β-catenin by two kinases, glycogen synthase kinase 3 (GSK3) and
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Wnt stimulates the stabilization of β-catenin through interactions with a receptor complex composed of the seven-transmembrane Frizzled and the single-transmembrane low-density lipoprotein receptor-related protein 5 or 6 (LRP5/6). In the absence of Wnt, dual phosphorylation of β-catenin by two kinases, glycogen synthase kinase 3 (GSK3) and
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O7. Regulation of Wnt/Lrp6 signalling
Differentiation, 2010The Wnt/β-catenin signaling pathway plays important roles in embryonic development and disease. Wnts transduce signals via transmembrane receptors of the Frizzled (Fzd) family and the low density lipoprotein receptor-related protein 5/6 (Lrp5/6).
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LRP6 and Arrow Function in Wnt Signaling
Science's STKE, 2000Three papers shed new light on Wnt signaling by characterizing the function of a low density lipoprotein (LDL) receptor-like protein (LRP). Tamai et al . showed in Xenopus that LRP6 acts as a Wnt coreceptor.
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