Results 191 to 200 of about 16,257 (211)

Abstract 19002: LRP6 Mutation (LRP6 _R611C ) Leads to PDGF Dependent Vascular Smooth Muscle Cell Hyperproliferation and Atherosclerosis

Circulation, 2012
A loss of function mutation in the Wnt co-receptor Low Density Lipoprotein Receptor Related Protein 6, (LRP6 R611C ) causes early atherosclerosis and metabolic syndrome in humans. We have generated LRP6 R611C mice with homologous recombination. LRP6
Roshni Srivastava, Arya Mani
openaire   +1 more source

Mest/Peg1 inhibits Wnt signalling through regulation of LRP6 glycosylation

Biochemical Journal, 2011
Mest (mesoderm-specific transcript)/Peg1 (paternally expressed gene 1) is an imprinted gene that plays important roles in embryo development, although its biochemical role has not been determined. Ectopic expression of Mest/Peg1 inhibited Wnt-mediated reporter activity by enhancing the ubiquitination of β-catenin.
Hwajin, Jung, Suk Kyung, Lee, Eek-hoon, Jho   +2 more
openaire   +2 more sources

LRP6 in Wnt Signaling and Breast Cancer Tumorigenesis

2010
Breast cancer is a diverse malignancy; understanding the molecular mechanisms driving tumor progression will facilitate development of targeted therapies. For example, tamoxifen, an anti-estrogen agent, used for treating estrogen receptor (ER)-positive breast tumors, and trastuzumab, a monoclonal antibody targeting HER2-overexpressing tumors, have ...
openaire   +2 more sources

LRP6 Gene

2020
openaire   +1 more source

Implication Of Lrp6 Variants In Familial Hypercholesterolemia

Atherosclerosis, 2019
Y. Ghaleb, S. Elbitar, A. Loste, P. El Khoury, Y. Abou-Khalil, G. Nicolas, M. Le Borgne, P. Moulin, M. Di-Filippo, S. Charriere, H. Iliozer, J.P. Rabès, C. Boileau, M. Abifadel, M. Varret   +14 more
openaire   +1 more source

In-silico identification of new inhibitors for Low-density lipoprotein receptor-related protein6 (LRP6)

Journal of Biomolecular Structure and Dynamics, 2022
Maryam Enayatkhani, Mona Salimi, Kayhan Azadmanesh   +2 more
exaly  

Faculty Opinions recommendation of Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature, 2007
openaire   +1 more source

The LDL Receptor-Related Protein LRP6 Mediates Internalization and Lethality of Anthrax Toxin

Cell, 2006
Wensheng Wei, Stephen H Leppla
exaly  

The Combined Hyperlipidemia Caused by Impaired Wnt-LRP6 Signaling Is Reversed by Wnt3a Rescue

Cell Metabolism, 2014
Gwang-Woong Go, Antonio Hernandez-Ono, Gyoungok Gang   +2 more
exaly  

Disabled-2 (Dab2) inhibits Wnt/β-catenin signalling by binding LRP6 and promoting its internalization through clathrin

EMBO Journal, 2012
Xi He, Philip H Howe
exaly