Results 131 to 140 of about 27,519 (289)

LSD1 deficiency in breast cancer cells promotes the formation of pre-metastatic niches

npj Precision Oncology
Lysine-specific demethylase 1 (LSD1), a histone demethylating enzyme, plays a crucial role in cancer metastasis. Studies show LSD1 knockout promotes breast cancer lung metastasis, but it’s unknown if it alters the lung microenvironment for metastasis. In
Yutong Yao, Rui Qian, Hanwei Gao, Yonghao Dai, Yueru Shi, Peipei An, Benkai Xin, Ziyu Liu, Nan Zhang, Youzhong Wan, Yuquan He, Xin Hu   +11 more
doaj   +1 more source

Genes involved in barley yellow dwarf virus resistance of maize [PDF]

, 2014
KEY MESSAGE: The results of our study suggest that genes involved in general resistance mechanisms of plants contribute to variation of BYDV resistance in maize. ABSTRACT: With increasing winter temperatures in Europe, Barley yellow dwarf virus (BYDV) is
Habekuss, A., Horn, F., Stich, B.
core   +2 more sources

Pharmacological Inhibition of LSD1 for Cancer Treatment

Molecules, 2018
Lysine-specific demethylase 1A (LSD1, also named KDM1A) is a demethylase that can remove methyl groups from histones H3K4me1/2 and H3K9me1/2. It is aberrantly expressed in many cancers, where it impedes differentiation and contributes to cancer cell proliferation, cell metastasis and invasiveness, and is associated with inferior prognosis ...
Guan-Jun Yang, Pui-Man Lei, Suk-Yu Wong, Dik-Lung Ma, Chung-Hang Leung   +4 more
openaire   +3 more sources

Whispers of Growth: The Impact of MicroRNA on the Proliferation Potential of Adipose‐Derived Stem Cells—A Review

BioMed Research International, Volume 2026, Issue 1, 2026.
Adipose‐derived stem cells (ADSCs) have garnered significant interest in regenerative medicine (RM) due to their abundant availability, ease of isolation, and ability to differentiate into various cell types. The growth of ADSCs is crucial for their therapeutic effectiveness, as it directly influences their ability to repair damaged tissues. MicroRNAs (
Maryam Bahrami, Hojjat Allah Abbaszadeh, Katayon Berjis, Ali Moradi, Ruixi Luo   +4 more
wiley   +1 more source

Lysine-Specific Histone Demethylase 1A Regulates Macrophage Polarization and Checkpoint Molecules in the Tumor Microenvironment of Triple-Negative Breast Cancer

Frontiers in Immunology, 2019
Macrophages play an important role in regulating the tumor microenvironment (TME). Here we show that classical (M1) macrophage polarization reduced expression of LSD1, nuclear REST corepressor 1 (CoREST), and the zinc finger protein SNAIL.
Abel H. Y. Tan, WenJuan Tu, Robert McCuaig, Kristine Hardy, Thomasina Donovan, Sofiya Tsimbalyuk, Jade K. Forwood, Sudha Rao   +7 more
doaj   +1 more source

Unlocking the dual role of LSD1 in tumor immunity: innate and adaptive pathways

Theranostics
The roles of innate and adaptive immunity are crucial in both the development of cancer and its response to treatment. Numerous studies have demonstrated that histone lysine-specific demethylase 1 (LSD1) is overexpressed in various cancers.

semanticscholar   +1 more source

Spatial Transcriptomics and snRNA‐seq Expose CAF Niches Orchestrating Dual Stromal‐Immune Barriers in Hepatocellular Carcinoma

Advanced Science, Volume 12, Issue 48, December 29, 2025.
HmmyCAFs may form a triple immunosuppressive niche: possibly secrete ECM (POSTN, etc.) as physical barriers to block CD8⁺ T cells, induce CD8⁺ T exhaustion via those molecules, and use HIF‐1α‐driven metabolism to create acidic, nutrient‐poor microenvironments that suppress T cells.
Yingxue Li, Changxiang Huan, Haoting Sun, Wei Zhang, Zhen Guo, Chuanyu Li, Jia Yao, Zhiqi Zhang, Shizhe Yu, Qiongzhu Dong, Lunxiu Qin, Jinze Li, Lianqun Zhou   +12 more
wiley   +1 more source

Relationship between seed harvesting method and seed physiological quality for a number of Pioneer maize hybrids [PDF]

, 2012
The seed germination and seed vigor of eight Pioneer Hi-Bred maize hybrids were evaluated immediately after harvesting and a year later. The aim was to determine whether the seed showed loss of germination and vigor when shelled mechanically.
Anda, Angéla, Berzy, Tamás, Ertsey, Katalin, Varga, Péter   +3 more
core   +1 more source

Characterization of the Epigenetic Changes During Human Gonadal Primordial Germ Cells Reprogramming [PDF]

, 2016
Epigenetic reprogramming is a central process during mammalian germline development. Genome-wide DNA demethylation in primordial germ cells (PGCs) is a prerequisite for the erasure of epigenetic memory, preventing the transmission of epimutations to the ...
Eguizábal, Cristina, Hajkova, Petra, Herrera, L., Izpisúa Belmonte, Juan Carlos, Montserrat, Núria, Oñate, Lorena de   +5 more
core   +1 more source

Spectrometry and Its Application for the Detection of RNA‐Binding Proteins: Advancements, Techniques and Challenges

Analytical Science Advances, Volume 6, Issue 2, December 2025.
ABSTRACT Spectrometry is a fascinating field of analytical science that encompasses a range of techniques used to study the interaction between electromagnetic radiation and matter. Through the measurement and analysis of various radiations, spectrometry provides valuable insights into the composition, structure and properties of different substances ...
Mina Moradi, Zahra Farjami, Mohammad Mehdi Akbarin   +2 more
wiley   +1 more source