Results 131 to 140 of about 24,350 (247)
PLoS ONE, 2013 Cholesterol 7α-hydroxylase (CYP7A1) catalyzes the first and rate-limiting step in the classical pathway of bile acids synthesis in liver and is crucial for maintaining lipid homeostasis. Hepatocyte nuclear factor 4α (HNF4α) and α1-fetoprotein transcription factor (FTF) are two major transcription factors driving CYP7A1 promoter activity in hepatocytes.
Huafang Ouyang +4 more
openaire +4 more sources
LSD1 dual function in mediating epigenetic corruption of the vitamin D signaling in prostate cancer
Clinical Epigenetics, 2017 Background Lysine-specific demethylase 1A (LSD1) is a key regulator of the androgen (AR) and estrogen receptors (ER), and LSD1 levels correlate with tumor aggressiveness. Here, we demonstrate that LSD1 regulates vitamin D receptor (VDR) activity and is a
Sebastiano Battaglia +7 more
doaj +1 more source
The scaffolding function of LSD1 controls DNA methylation in mouse ESCs
Nature CommunicationsLysine-specific histone demethylase 1 (LSD1), which demethylates mono- or di- methylated histone H3 on lysine 4 (H3K4me1/2), is essential for early embryogenesis and development.
Sandhya Malla +24 more
doaj +1 more source
Scientific Reports, 2017 Lysine-specific demethylase 1 (LSD1) is a histone demethylase that participates in transcriptional repression or activation. Recent studies reported that LSD1 is involved in learning and memory.
Chae-Seok Lim +20 more
doaj +1 more source
RETRACTED: Long Noncoding RNA LINC00673 Is Activated by SP1 and Exerts Oncogenic Properties by Interacting with LSD1 and EZH2 in Gastric Cancer [PDF]
, 2017 Mingde Huang +7 more
openalex +1 more source
LSD1 is required for chromosome segregation during mitosis
European Journal of Cell Biology, 2010 Dynamic methylation/demethylation of histones and non-histone proteins occurs during the cell cycle. Lysine-specific demethylase 1 (LSD1) exhibits diverse transcriptional activities through catalyzing demethylation of mono- and di-methylated histone H3 on lysine 4 (H3K4) and lysine 9 (H3K9).
Shuang, Lv +8 more
openaire +2 more sources
Crosstalk between lysine-specific demethylase 1 (LSD1) and histone deacetylases mediates antineoplastic efficacy of HDAC inhibitors in human breast cancer cells [PDF]
, 2013 Shauna N. Vasilatos +5 more
openalex +1 more source
The histone demethylase Lsd1 regulates multiple repressive gene programs during T cell development
, 2021 Daniel B. Stamos +13 more
openalex +2 more sources