Results 231 to 240 of about 340,028 (311)

WTAP Transcriptional Suppression by KLF9 Drives Osteoclastogenesis via M6A‐Mediated Regulation of CSF1R Signaling in Estrogen‐Deficient Osteoporosis

Advanced Science, EarlyView.
Scheme of the KLF9/WTAP/YTHDF2/m6A/CSF1R regulatory axis in osteoclastogenesis and estrogen‐deficient osteoporosis. WTAP‐mediated m6A modification of Csf1r mRNA governs osteoclastogenesis via a YTHDF2‐mediated pathway. Pathological upregulation of KLF9 drives Wtap transcription, leading to increased m6A deposition on the 3’‐UTR of Csf1r mRNA.
Chen Shen, Xin Liu, Gaoran Ge, Li Xu, Ziyu Zhang, Chang Lv, Hao Xu, Wenhao Li, Yi Qin, Qifeng Sheng, Qihan Wang, Hongxia Li, Jun Zhou, Huilin Yang, Dechun Geng   +14 more
wiley   +1 more source

Calcium-Triggered PuMYB44-PuERF118 Cascade Activates <i>PuFAD8</i> to Promote Aroma Biosynthesis in Pear Fruit. [PDF]

Int J Mol Sci
Wang X, Yao G, Zhang M, Song H, Cao Z, Hu K, Gai X, Zhang H, Qin G.   +8 more
europepmc   +1 more source

A Drug‐Gated, Modular STAb‐T Immunotherapy With External Control

Advanced Science, EarlyView.
Engineered STAb‐TON cells act as programmable living factories that continuously secrete inactive antibody modules, which assemble extracellularly into a functional T cell engager only upon small‐molecule administration. This externally controlled platform enables reversible, on‐demand regulation of antitumor immunity, establishing a new paradigm for ...
Susana Luengo‐Arias, Carmen Domínguez‐Alonso, Ivana Zagorac, Antonio Tapia‐Galisteo, Eva García‐Veros, Laura Rubio‐Pérez, Marina Gómez‐Rosel, Patricia Fuentes, Patricia Hernández‐López, Óscar Aguilar‐Sopeña, Laura Almagro‐Puente, Sonia Martínez‐González, Lucía Cañizares‐Moscato, María Rivas‐Sánchez, Belén Blanco, Ángel Ramírez‐Fernández, Laura Díez‐Alonso, Carmen Blanco‐Aparicio, Javier Arroyo‐Ródenas, Jorge Martínez‐Torrecuadrada, María L. Toribio, Pedro Roda‐Navarro, Anaïs Jiménez‐Reinoso, Luis Álvarez‐Vallina   +23 more
wiley   +1 more source

Acupuncture alleviates secondary brain injury in intracerebral hemorrhage-induced rats through activating the LKLF/Mfn2 pathway. [PDF]

Braz J Med Biol Res
Kong Y, Qu X, Zhou Z, Tian Q, Sun H, Zhang D, Zhang Y, Han Z.   +7 more
europepmc   +1 more source

An Intravesical Akkermansia muciniphila‐Based Chemo‐Immunotherapeutic Platform for Bladder Cancer

Advanced Science, EarlyView.
Pasteurized Akkermansia muciniphila is engineered into an intravesical F127/doxorubicin platform that couples localized chemotherapy with immune remodeling. By inducing apoptosis, ferroptosis, and immunogenic cell death, this chemo‐immunotherapeutic system enhances dendritic‐cell maturation, antigen cross‐presentation, and tumor‐specific CD8+ T‐cell ...
Rongkang Li, Anguo Zhao, Qi Zhuang, Lei Peng, Rui Liang, Jiadong Zhao, Yang Liu, Dashi Deng, Peng Yu, Xiqi Peng, Shaohua Zhang, Song Wu   +11 more
wiley   +1 more source

Analysis of cancer mutations introduced into the <i>Drosophila melanogaster</i> Notch negative regulatory region uncovers a diversity of regulatory outcomes. [PDF]

Elife
Shimizu H, Baron M.
europepmc   +1 more source

Nardilysin regulates <i>Slc2a2</i> expression via an ISLET1-dependent enhancer mechanism in pancreatic β-cells. [PDF]

Biochem Biophys Rep
Nishi K, Ganbaatar N, Ohno M, Ikeda S, Iwasaki H, Batbaatar MA, Gansukh E, Nishi E.   +7 more
europepmc   +1 more source

Refining OVCAR-3 xenograft models of peritoneal carcinomatosis in nu/nu mice: Comparative intraperitoneal implantation strategies and the role of basement membrane matrix. [PDF]

Animal Model Exp Med
Perelló-Trias MT, Serrano-Muñoz AJ, Segura-Sampedro JJ, Quintero-Duarte AM, Ramis JM, Monjo M.   +5 more
europepmc   +1 more source

High prevalence of autoantibodies neutralizing type I IFNs in Japanese patients with hepatitis C. [PDF]

J Hum Immun
Taniguchi M, Tao C, Asano T, Tsumura M, Ko K, Kumada H, Utsumi T, Noma K, Sakura F, Ashihara K, Tamaura M, Mizoguchi Y, Ohara O, Bogunovic D, Bastard P, Casanova JL, Tanaka J, Tsuge M, Chayama K, Oka S, Okada S.   +20 more
europepmc   +1 more source