Results 131 to 140 of about 19,699 (283)
Investigation of the in vitro inhibitory mechanisms of quercetin on varicella-zoster virus [PDF]
, 2015 摘要 【目的】 1、应用水痘-带状疱疹病毒（VZV）报告细胞系MV9G细胞从植物药成分中筛选具有抑制VZV作用的物质。 2、应用VZV报告细胞系MV9G研究槲皮素体外抑制VZV作用及其机制。 【方法】 1、植物药成分的细胞毒性试验：MV9G细胞分别在含有丁子香酚、桑色素、姜黄素、杨梅酮和槲皮素的培养基中培养72hrs后测定MV9G细胞的ATP含量，根据药物对MV9G细胞ATP含量的影响分析药物的细胞毒性，并计算植物药成分对MV9G细胞的半数致死浓度（CD50）。 2、植物药成分对VZV半数抑制浓度测定 ...
廉成翔
core
Tethering of proteins to RNAs by bacteriophage proteins.
, 2008 International audienceMany steps in the control of gene expression are dependent on RNA-binding proteins, most of which are bi-functional, in as much as they both bind to RNA and interact with other protein partners in a functional complex.
Barreau, Carine +2 more
core +2 more sources
Advanced Science, EarlyView.PDAC has a poor prognosis due to chemoresistance. We revealed that MCU upregulation is associated with chemoresistance and stemness in PDAC. MCU‐mediated Ca2+ influx induced ER stress, activating the PERK‐ATF4/NRF2 axis to enhance PSAT1/SLC711 expression and glutathione synthesis, reducing ROS and maintaining stemness.
Zekun Li +17 more
wiley +1 more source
Stable transformation of an Arabidopsis cell suspension culture with firefly luciferase providing a cellular system for analysis of chaperone activity in vivo. [PDF]
, 1997 Christoph Forreiter +2 more
openalex +1 more source
Advanced Science, EarlyView.This study identifies Rubicon as a key platelet protein that bidirectionally regulates GPVI and integrin αIIbβ3 signaling. Platelet Rubicon protects against cerebral ischemia‐reperfusion injury by limiting infarction without increasing hemorrhage.
Xiaoyan Chen +11 more
wiley +1 more source
ホタル生物発光における発光制御機構の化学生物学的研究 [PDF]
, 2016 Firefly bioluminescence is an enzymatic reaction, which requires Mg2+, ATP, and O2. The mechanism of this bioluminescence is as follows; first, the luciferase catalyzes the adenylylation of the luciferin and then the oxygenation of the adenylylated ...
Satoshi Iwano, 岩野 智
core +2 more sources
Advanced Science, EarlyView.Oxidative phosphorylation (OXPHOS) activity serves as a critical metabolic determinant of radiotherapy outcomes in esophageal squamous cell carcinoma (ESCC). The CEBPB/AREG/EREG axis drives radioresistance in ESCC by reprogramming OXPHOS. AREG and EREG function as predictive biomarkers for nCRT response and prognosis of ESCC patients.
Zhang Lin +15 more
wiley +1 more source
Transient Expression of B-Glucuronidase and Luciferase in Electroporated Conifer Protoplasts [PDF]
, 1991 Michael Campbell +2 more
openalex +1 more source
Metformin Impairs Breast Cancer Growth through the Inhibition of PRMT6
Advanced Science, EarlyView.Metformin has a biological activity against breast cancer. However, it is largely unknown about its precise therapeutic targets. Here, histone arginine methyltransferase PRMT6 is identified as a new anti‐cancer target for metformin. Metformin directly binds PRMT6 and inhibits its ability to catalyze histone H3R2 asymmetric dimethylation (H3R2me2a ...
Yinsheng Wu +9 more
wiley +1 more source