Results 71 to 80 of about 85,623 (327)
Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry
Molecular Oncology, EarlyView.Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson +11 more
wiley +1 more source
Single-Particle Optical Imaging for Ultrasensitive Bioanalysis
Biosensors, 2022 The quantitative detection of critical biomolecules and in particular low-abundance biomarkers in biofluids is crucial for early-stage diagnosis and management but remains a challenge largely owing to the insufficient sensitivity of existing ensemble ...
Yujie Liu +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma +9 more
wiley +1 more source
Materials & Design, 2023 Highly sensitive detection of melanoma-derived exosomal PD-L1 plays a key role in non-invasive diagnosis of melanoma. Here, we proposed a self-calibrated magnetic aptamer sensor (sCMAS) for sensitive detection of melanoma exosomal PD-L1, using the dual ...
Nanhang Zhu +6 more
doaj
A Cell Line for Detection of Botulinum Neurotoxin Type B
Frontiers in Pharmacology, 2017 Botulinum neurotoxins (BoNTs) type A and type B are commonly used as biopharmaceutics for neurological diseases, uniquely allowing months-long paralysis of target muscles.
Aleksander Rust +7 more
doaj +1 more source
Fluorescent labeling of plasmid DNA and mRNA : gains and losses of current labeling strategies [PDF]
, 2016 Live-cell imaging has provided the life sciences with insights into the cell biology and dynamics. Fluorescent labeling of target molecules proves to be indispensable in this regard. In this Review, we focus on the current fluorescent labeling strategies
Rombouts, Koen +2 more
core +1 more source
FEBS Open Bio, EarlyView.Etoposide, a topoisomerase II inhibitor, reduces O‐GlcNAcylation in HepG2 liver cancer cells. Further inhibition of O‐GlcNAc transferase by OSMI‐1 enhanced etoposide‐induced apoptosis, lowering the IC50 for viability and increasing the EC50 for cytotoxicity.
Jaehoon Lee +5 more
wiley +1 more source
A single-component luminescent biosensor for the SARS-CoV-2 spike protein [PDF]
, 2022 Matthew Ravalin +6 more
openalex +3 more sources
The influence of poly (2-methoxyaniline-5-sulfonic acid) on the electrochemical and photochemical properties of a highly luminescent ruthenium complex [PDF]
, 2008 Immobilisation of a luminescent material on an electrode surface is well known to substantially modulate its photophysical and electrochemical properties.
Bard +41 more
core +1 more source
FEBS Open Bio, EarlyView.Ca2+‐mediated response to DMSO was investigated in Saccharomyces cerevisiae cells expressing Ca2+‐dependent aequorin. Cell exposure to DMSO induced a cytosolic Ca2+ wave dependent on the integrity of the Cch1/Mid1 channel. Deletion of KCS1 or VIP1 genes encoding the phosphoinositol pyrophosphate (PP‐IP) synthases suppressed the DMSO‐induced Ca2 ...
Larisa Ioana Gogianu +4 more
wiley +1 more source