Results 121 to 130 of about 3,948,840 (323)
Comprehensive genomic characterization of squamous cell lung cancers
Nature, 2012 Lung squamous cell carcinoma is a common type of lung cancer, causing approximately 400,000 deaths per year worldwide. Genomic alterations in squamous cell lung cancers have not been comprehensively characterized, and no molecularly targeted agents have ...P. Hammerman, Douglas Voet, M. Lawrence, Douglas Voet, R. Jing, K. Cibulskis, A. Sivachenko, P. Stojanov, A. McKenna, E. Lander, S. Gabriel, G. Getz, M. Imieliński, E. Helman, Bryan Hernandez, Nam Pho, M. Meyerson, Andy Chu, Jung E. Hye-Chun, A. Mungall, E. Pleasance, A. G. Robertson, Payal Sipahimalani, D. Stoll, M. Balasundaram, I. Birol, Y. Butterfield, E. Chuah, R. Coope, R. Corbett, Noreen Dhalla, R. Guin, A. He, Carrie Hirst, M. Hirst, R. Holt, Darlene Lee, H. Li, Michael Mayo, Richard A. Moore, K. Mungall, K. Nip, A. Olshen, J. Schein, Jared R. Slobodan, Angela Tam, N. Thiessen, R. Varhol, Thomas Zeng, Yongjun Zhao, Steven J. M. Jones, M. Marra, G. Saksena, A. Cherniack, S. Schumacher, B. Tabak, S. Carter, Huy L. Nguyen, R. Onofrio, A. Crenshaw, K. Ardlie, R. Beroukhim, W. Winckler, A. Protopopov, Jianhua Zhang, Angela Hadjipanayis, Semin Lee, Ruibin Xi, Lixing Yang, X. Ren, Hailei Zhang, S. Shukla, Peng-Chieh Chen, Psalm S. Haseley, E. Lee, L. Chin, P. Park, R. Kucherlapati, N. Socci, Yupu Liang, N. Schultz, L. Borsu, A. Lash, A. Viale, C. Sander, M. Ladanyi, J. Auman, K. Hoadley, M. Wilkerson, Yan Shi, C. Liquori, S. Meng, Ling Li, Yidi J. Turman, M. D. Topal, Donghui Tan, S. Waring, Elizabeth Buda, Jesse L. Walsh, Corbin D. Jones, P. Mieczkowski, Darshan Singh, Junyuan Wu, Anisha Gulabani, Peter Dolina, T. Bodenheimer, A. Hoyle, J. Simons, Matthew G. Soloway, Joshua M. Stuart, Lisle E. Mose, S. Jefferys, S. Balu, Brian D. O’Connor, Derek Y. Chiang, Jinze Liu, D. Hayes, C. Perou, L. Cope, D. Weisenberger, Ludmila V. Danilova, D. Weisenberger, D. Maglinte, F. Pan, D. V. Berg, T. Triche, J. Herman, S. Baylin, P. Laird, M. Noble, Nils Gehlenborg, D. Dicara, Jinhua Zhang, Chang-Jiun Wu, Spring Yingchun Liu, L. Zou, Pei Lin, Juok Cho, Marc-Danie Nazaire, James Robinson, H. Thorvaldsdóttir, J. Mesirov, Rileen Sinha, G. Ciriello, E. Cerami, Benjamin E. Gross, A. Jacobsen, Jianjiong Gao, B. A. Aksoy, Nils Weinhold, Ricardo Ramirez, B. Taylor, Yevgeniy Antipin, B. Reva, Qianxing Mo, V. Seshan, P. Paik, Rehan Akbani, Nianxiang Zhang, B. Broom, Tod D. Casasent, A. Unruh, Chris Wakefield, R. Cason, K. Baggerly, J. Weinstein, D. Haussler, C. Benz, Jingchun Zhu, C. Szeto, G. Scott, C. Yau, S. Ng, Theodore Goldstein, Peter Waltman, Artem Sokolov, E. Collisson, K. Ellrott, D. Zerbino, Singer Ma, Brian Craft, Ying Du, Christopher R. Cabanski, Vonn Walter, J. Marron, Yufeng Liu, Kai Wang, J. Prins, C. Creighton, Yiqun Zhang, W. Travis, N. Rekhtman, Joanne E. Yi, M. Aubry, R. Cheney, S. Dacic, D. Flieder, W. Funkhouser, P. Illei, J. Myers, M. Tsao, R. Penny, D. Mallery, T. Shelton, M. Hatfield, S. Morris, P. Yena, C. Shelton, M. Sherman, J. Paulauskis, R. Govindan, I. Azodo, D. Beer, R. Bose, L. Byers, D. Carbone, Li-Wei Chang, Elizabeth Chun, L. Ding, J. Heymach, C. Ida, B. Johnson, I. Jurisica, J. Kaufman, F. Kosari, D. Kwiatkowski, C. Maher, A. Mungall, W. Pao, M. Peifer, Gordon Robertson, V. Rusch, J. Siegfried, C. Sougnez, Roman K. Thomas, S. Tomaszek, Charles J. Vaske, D. Wheeler, D. Wigle, C. Wilks, J. Zhang, M. Jensen, R. Sfeir, A. Kahn, A. Chu, Prachi Kothiyal, Zhining Wang, E. Snyder, J. Pontius, T. Pihl, Brenda Ayala, M. Backus, Jessica L Walton, J. Baboud, D. Berton, M. Nicholls, Deepak Srinivasan, R. Raman, Stanley Girshik, Peter A. Kigonya, S. Alonso, Rashmi N. Sanbhadti, S. Barletta, J. Greene, D. Pot, B. Bandarchi-Chamkhaleh, J. Boyd, J. Weaver, I. Azodo, C. Ida, Ping Yang, M. Brock, K. Rogers, M. Rutledge, T. Brown, Beverly Lee, James Shin, D. Trusty, R. Dhir, O. Potapova, K. Fedosenko, Elena Nemirovich-Danchenko, M. Zakowski, M. Iacocca, Jennifer Brown, B. Rabeno, Christine Czerwinski, N. Petrelli, Zhen Fan, N. Todaro, J. Eckman, W. Rathmell, L. Thorne, Meijuan Huang, L. Boice, Ashley D. Hill, Erin E. Curley, C. Morrison, Carmelo Gaudioso, J. Bartlett, S. Kodeeswaran, B. Zanke, H. Sekhon, K. David, H. Juhl, X. Le, B. Kohl, Richard A. Thorp, N. V. Tien, N. V. Bang, H. Sussman, Bui Duc Phu, R. Hajek, N. P. Hung, K. Z. Khan, T. Muley, K. Shaw, Margi Sheth, Liming Yang, K. Buetow, Tanja Davidsen, John A. Demchok, G. Eley, M. Ferguson, Laura A. L. Dillon, C. Schaefer, M. Guyer, B. Ozenberger, Jacqueline D. Palchik, Jane L. Peterson, H. Sofia, E. Thomson, R. Shen +332 moresemanticscholar +1 more sourceCystic Lung Phantom to Validate Clinical CT Protocols [PDF]
arXivIn CT-based evaluation of the extent of cystic changes in the lungs of
patients with cystic lung diseases, such as Lymphangioleiomyomatosis (LAM),
there is a lack of a lung phantom containing air-filled cavities that mimic
pulmonary cysts to calibrate the measurement of cystic volumes from CT scans.arxiv CircCCNB1 inhibits vasculogenic mimicry by sequestering NF90 to promote miR‐15b‐5p and miR‐7‐1‐3p processing in nasopharyngeal carcinoma
Molecular Oncology, EarlyView.CircCCNB1 expression is down‐regulated in nasopharyngeal carcinoma (NPC); thus, less NF90 protein is bound to circCCNB1 and more binds to pri‐miRNAs, blocking their (pri‐miRNAs) binding to DGCR8 and inhibiting the processing and generation of miR‐15b‐5p/miR‐7‐1‐3p. Furthermore, decreased miR‐15b‐5p/miR‐7‐1‐3p promotes the expression of the target genes Chunmei Fan, Fenghua Tan, Jie Wu, Zhaoyang Zeng, Wenjia Guo, He Huang, Wei Xiong +6 morewiley +1 more sourceAdverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer
Molecular Oncology, EarlyView.We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...Marina N. Sharifi, Eric Feng, Nicholas R. Rydzewski, Amy K. Taylor, Jamie M. Sperger, Yue Shi, Kyle T. Helzer, Matthew L. Bootsma, Viridiana Carreno, Alex H. Chang, Luke A. Nunamaker, Grace C. Blitzer, Tianfu Andy Shang, Aishwarya Subramanian, Anders Bjartell, Andreas Josefsson, Pernilla Wikström, Emily Feng, Manish Kohli, Rendong Yang, Scott M. Dehm, Eric J. Small, Rahul Aggarwal, David A. Quigley, Joshua M. Lang, Shuang G. Zhao, Martin Sjöström +26 morewiley +1 more sourceThe atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids
Molecular Oncology, EarlyView.TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger +17 morewiley +1 more source
