Results 51 to 60 of about 279,339 (314)

Expression of FAT1 in Lung Adenocarcinoma and Its Relationship 
with Immune Cell Infiltration

Chinese Journal of Lung Cancer
Background and objective Lung cancer is a leading cause of cancer-related deaths. Non-small cell lung cancer (NSCLC) is the most common pathological subtype, with adenocarcinoma being the predominant type.
Chen DING, Wenhao ZHAO, Hua HUANG, Yongwen LI, Zhanrui ZHANG, Ruihao ZHANG, Yanan WANG, Di WU, Chen CHEN, Hongyu LIU, Jun CHEN   +10 more
doaj   +1 more source

Expression of ASPM in Lung Adenocarcinoma and Its Relationship with Development and Prognosis

Chinese Journal of Lung Cancer, 2020
Background and objective Previous studies have shown that ASPM is a tumorigenesis associated protein, mutations in ASPM can lead to MCPH. This study mainly explores the relationship between the ASPM expression of lung adenocarcinoma and the development ...
Junjie WANG, Zhenyu HE, Renhui DUAN
doaj   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

THORACIC CT-SCAN WITH EGFR MUTATIONS IN PULMONARY ADENOCARCINOMA PATIENTS WITH PULMONARY METASTASES AT DR. MOEWARDI HOSPITAL, SURAKARTA, INDONESIA

Majalah Biomorfologi, 2023
Highlights • The thoracic CT scan can be an alternative evaluation before administering EGFR-targeting medicine to patients. • EGFR is now a therapeutic target for lung cancer.
Viska Wahyu Arianti, Widiastuti Soewondo, Sulistiyani Kusumaningrum, Muhammad Lukman Hermansyah, Yusup Subagio Sutanto, Hari Wujoso   +5 more
doaj   +1 more source

Achalasia secondary to lung adenocarcinoma

The Korean Journal of Internal Medicine, 2015
To the Editor, Pseudoachalasia is a rare entity and is difficult to distinguish from idiopathic achalasia. The most common cause of achalasia secondary to neoplasia is adenocarcinoma of the distal esophagus and the gastroesophageal junction. The second most common cause is small-cell lung cancer [1]. We report a case of lung adenocarcinoma secondary
Burak Can, Fatih Balli, Ugur Korkmaz, Yılmaz, Hayati, Fatma Inci Can, Çelebi, Ahmet   +5 more
openaire   +3 more sources

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

Molecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen, Chung‐Teng Wang, Jia‐Ming Chang, Ai‐Li Shiau, Gia‐Shing Shieh, Yau‐Lin Tseng, Yi‐Ting Yen, Tang‐Hsiu Huang, Li‐Hsin Cheng, Yu‐Chih Wu, Chao‐Liang Wu, Bing‐Hua Su, Pensee Wu   +12 more
wiley   +1 more source

Mechanism of DERL3 Affecting the Proliferation, Invasion and Metastasis of Lung Adenocarcinoma A549 Cells

Chinese Journal of Lung Cancer, 2020
Background and objective Derlin 3 (DERL3) is downregulated in colorectal cancer (CRC) samples. Its level is closely linked to lymphatic metastasis or distant metastasis rate in CRC patients.
Dandan ZHOU, Jiemin WANG, Ke YANG, Liping ZHANG, Quan ZHENG, Jun BAI, Yaqiong HU, Qingjie MU, Chonggao YIN, Hongli LI   +9 more
doaj   +1 more source

Landscape of BRAF transcript variants in human cancer

Molecular Oncology, EarlyView.
We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda, Danilo Tatoni, Gianluca Mattei, Alberto Magi, Romina D'Aurizio, Laura Poliseno   +5 more
wiley   +1 more source

TRIM2 directly deubiquitinates and stabilizes Snail1 protein, mediating proliferation and metastasis of lung adenocarcinoma

Cancer Cell International, 2020
Background Lung adenocarcinoma has surpassed lung squamous cell carcinoma as the most common type of non-small cell lung cancer. In this study, we had tested the biological role of TRIM2 in lung adenocarcinoma. Methods TRIM2 abundance in clinical tissues
Zhaoxian Lin, Xing Lin, Lihuan Zhu, Jianyuan Huang, Yangyun Huang   +4 more
doaj   +1 more source