Results 51 to 60 of about 7,594,057 (369)

Immunotherapy in Lung Cancer: Current Landscape and Future Directions

Frontiers in Immunology, 2022
Over the past decade, lung cancer treatment has undergone a major paradigm shift. A greater understanding of lung cancer biology has led to the development of many effective targeted therapies as well as of immunotherapy.
H. Mamdani, S. Matosevic, Ahmed Bilal Khalid, Gregory A Durm, S. Jalal   +4 more
semanticscholar   +1 more source

Nivolumab plus Ipilimumab in Lung Cancer with a High Tumor Mutational Burden

New England Journal of Medicine, 2018
BACKGROUND Nivolumab plus ipilimumab showed promising efficacy for the treatment of non–small‐cell lung cancer (NSCLC) in a phase 1 trial, and tumor mutational burden has emerged as a potential biomarker of benefit.
M. Hellmann, T. Ciuleanu, A. Płużański, J. Lee, G. Otterson, C. Audigier-Valette, E. Minenza, H. Linardou, S. Burgers, P. Salman, H. Borghaei, S. Ramalingam, J. Brahmer, M. Reck, K. O'Byrne, W. Geese, G. Green, Han-Cheng Chang, J. Szustakowski, P. Bhagavatheeswaran, D. Healey, Yali Fu, F. Nathan, L. Paz-Ares   +23 more
semanticscholar   +1 more source

Screening for Lung Cancer: US Preventive Services Task Force Recommendation Statement.

Journal of the American Medical Association (JAMA), 2021
Importance Lung cancer is the second most common cancer and the leading cause of cancer death in the US. In 2020, an estimated 228 820 persons were diagnosed with lung cancer, and 135 720 persons died of the disease.
A. Krist, K. Davidson, C. Mangione, M. Barry, M. Cabana, A. Caughey, E. Davis, Katrina E. Donahue, Chyke A Doubeni, Martha Y. Kubik, C. Landefeld, Li Li, G. Ogedegbe, D. Owens, L. Pbert, Michael Silverstein, J. Stevermer, Chien-Wen Tseng, J. Wong   +18 more
semanticscholar   +1 more source

A pyrazolopyran derivative preferentially inhibits the activity of human cytosolic hydroxymethyltransferase and induces cell death in lung cancer cells [PDF]

, 2015
Serine hydroxymethyltransferase (SHMT) is a central enzyme in the metabolic reprogramming of cancer cells, providing activated one-carbon units in the serine-glycine one-carbon metabolism.
CONTESTABILE, Roberto, CUTRUZZOLA', Francesca, FIASCARELLI, ALESSIO, Gargano, Maurizio, GIARDINA, Giorgio, Koes, David, MACONE, ALBERTO, MARANI, MARINA, Mcdermott, Lee, PAIARDINI, ALESSANDRO, PAONE, ALESSIO, Pontecorvi, Valentino, RINALDO, Serena, Yang, Tianyi   +13 more
core   +1 more source

Erratum: Study on the Biological Function of Abemecilib in Inhibiting the Proliferation, Invasion and Migration of Small Cell Lung Cancer with High c-Myc Expression

Chinese Journal of Lung Cancer, 2023
Erratum: Study on the Biological Function of Abemecilib in Inhibiting the Proliferation, Invasion and Migration of Small Cell Lung Cancer with High c-Myc Expression Guo JJ, Mu D, Yu WW, et al. Zhongguo Fei Ai Za Zhi, 2023, 26(2): 105-112.
Editorial Office of Chinese Journal of Lung Cancer
doaj   +1 more source

Systemic Metabolomic Changes in Blood Samples of Lung Cancer Patients Identified by Gas Chromatography Time-of-Flight Mass Spectrometry. [PDF]

, 2015
Lung cancer is a leading cause of cancer deaths worldwide. Metabolic alterations in tumor cells coupled with systemic indicators of the host response to tumor development have the potential to yield blood profiles with clinical utility for diagnosis and ...
Barupal, Dinesh K, Fiehn, Oliver, Gandara, David R, Hanash, Samir M, Kim, Kyoungmi, Miyamoto, Suzanne, Taguchi, Ayumu, Taylor, Sandra L, Wikoff, William R, Wohlgemuth, Gert, Yoneda, Ken Y   +10 more
core   +2 more sources

Lung cancer [PDF]

Breathe, 2016
While smoking tobacco is linked to more than 80% of all lung cancer cases, many people that have never smoked or been exposed to passive smoke develop lung cancer.
openaire   +2 more sources

Simple and objective prediction of survival in patients with lung cancer: staging the host systemic inflammatory response [PDF]

, 2014
Background. Prediction of survival in patients diagnosed with lung cancer remains problematical. The aim of the present study was to examine the clinical utility of an established objective marker of the systemic inflammatory response, the Glasgow ...
Brown, Louise, Devereux, Graham, Docherty, Kirsty, Grose, Derek, Jones, Richard, McElhinney, Penny, McIntosh, David, McMillan, Donald C., Milroy, Robert, Morrison, David S., Nicolson, Marianne, Selby, Colin, Sharma, Dave   +12 more
core   +4 more sources

Validation of stage groupings in the eighth edition of the tumor node metastasis classification for lung adenocarcinoma

Thoracic Cancer, 2019
Background The purpose of this study was to validate stage groupings in the 8th edition of the tumor node metastasis (TNM) classification for lung adenocarcinoma and explore the non‐anatomic factors that influence the prognosis of lung adenocarcinoma ...
Wenguan Yu, Qingchun Zhao, Chunqiu Xia, Ming Dong, Jinghao Liu, Xin Li, Honglin Zhao, Gang Chen, Hongyu Liu, Jun Chen   +9 more
doaj   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source