Results 1 to 10 of about 236,220 (185)

Spirometry and Obstructive Lung Disease in Manitoba [PDF]

Canadian Respiratory Journal, 2001
BACKGROUND: Spirometry, the measurement of forced expiratory volume in 1 s and forced vital capacity, is recommended in the diagnosis and management of the obstructive lung diseases asthma and chronic obstructive pulmonary disease (COPD).
NR Anthonisen, N Dik, J Manfreda, LL Roos   +3 more
doaj   +5 more sources

Descriptors of dyspnea in obstructive lung diseases [PDF]

Multidisciplinary Respiratory Medicine, 2010
In obstructive lung diseases such as asthma and COPD dyspnea is a common respiratory symptom with different characteristics given the different pathogenic mechanisms: in COPD initially it can occur during exertion but then it increases progressively ...
Antoniu Sabina A
doaj   +4 more sources

Exosomes and Exosomal miRNA in Respiratory Diseases [PDF]

, 2016
Exosomes are nanosized vesicles released from every cell in the body including those in the respiratory tract and lungs. They are found in most body fluids and contain a number of different biomolecules including proteins, lipids, and both mRNA and ...
Adcock, IM, Alipoor, SD, Garssen, J, Mirsaeidi, M, Mortaz, E, Movassaghi, M   +5 more
core   +40 more sources

Qualitative and quantitative evaluation of computed tomography changes in adults with cystic fibrosis treated with elexacaftor-tezacaftor-ivacaftor: a retrospective observational study

Frontiers in Pharmacology, 2023
Introduction: The availability of highly effective triple cystic fibrosis transmembrane conductance regulator (CFTR) modulator combination therapy with elexacaftor–tezacaftor–ivacaftor (ETI) has improved pulmonary outcomes and quality of life of people ...
Sabine Dettmer, Sabine Dettmer, Oliver Weinheimer, Oliver Weinheimer, Annette Sauer-Heilborn, Oliver Lammers, Mark O. Wielpütz, Mark O. Wielpütz, Jan Fuge, Jan Fuge, Tobias Welte, Tobias Welte, Frank Wacker, Frank Wacker, Felix C. Ringshausen, Felix C. Ringshausen, Felix C. Ringshausen   +16 more
doaj   +1 more source

Ciliary Ultrastructure Assessed by Transmission Electron Microscopy in Adults with Bronchiectasis and Suspected Primary Ciliary Dyskinesia but Inconclusive Genotype

Cells, 2023
Whole-exome sequencing has expedited the diagnostic work-up of primary ciliary dyskinesia (PCD), when used in addition to clinical phenotype and nasal nitric oxide. However, it reveals variants of uncertain significance (VUS) in established PCD genes or (
Ben O. Staar, Jan Hegermann, Bernd Auber, Raphael Ewen, Sandra von Hardenberg, Ruth Olmer, Isabell Pink, Jessica Rademacher, Martin Wetzke, Felix C. Ringshausen   +9 more
doaj   +1 more source

Interleukin‐17A and interleukin‐22 production by conventional and non‐conventional lymphocytes in three different end‐stage lung diseases

Clinical & Translational Immunology, 2022
Objectives The contribution of adaptive vs. innate lymphocytes to IL‐17A and IL‐22 secretion at the end stage of chronic lung diseases remains largely unexplored. In order to uncover tissue‐ and disease‐specific secretion patterns, we compared production
Melanie Albrecht, Olga Halle, Svenja Gaedcke, Sophia T Pallenberg, Julia Camargo Neumann, Marius Witt, Johanna Roediger, Marina Schumacher, Adan Chari Jirmo, Gregor Warnecke, Danny Jonigk, Peter Braubach, David DeLuca, Gesine Hansen, Anna‐Maria Dittrich   +14 more
doaj   +1 more source

The Relationship between Plasma Alpha-1-Antitrypsin Polymers and Lung or Liver Function in ZZ Alpha-1-Antitrypsin-Deficient Patients

Biomolecules, 2022
Alpha-1-Antitrypsin (AAT) is a protein of the SERPINA1 gene. A single amino acid mutation (Lys342Glu) results in an expression of misfolded Z-AAT protein, which has a high propensity to intra- and extra-cellular polymerization.
Annelot D. Sark, Malin Fromme, Beata Olejnicka, Tobias Welte, Pavel Strnad, Sabina Janciauskiene, Jan Stolk   +6 more
doaj   +1 more source

Spirometric and anthropometric improvements in response to elexacaftor/tezacaftor/ivacaftor depending on age and lung disease severity

Frontiers in Pharmacology, 2023
Introduction: Triple-combination cystic fibrosis transmembrane conductance regulator (CFTR) modulator therapy with elexacaftor/tezacaftor/ivacaftor (ETI) was introduced in August 2020 in Germany for people with CF (pwCF) ≥12 years (yrs.) of age and in ...
Katharina Schütz, Katharina Schütz, Sophia Theres Pallenberg, Sophia Theres Pallenberg, Julia Kontsendorn, David DeLuca, David DeLuca, Cinja Sukdolak, Cinja Sukdolak, Rebecca Minso, Rebecca Minso, Tina Büttner, Tina Büttner, Tina Büttner, Martin Wetzke, Christian Dopfer, Annette Sauer-Heilborn, Felix C. Ringshausen, Felix C. Ringshausen, Felix C. Ringshausen, Sibylle Junge, Burkhard Tümmler, Burkhard Tümmler, Gesine Hansen, Gesine Hansen, Anna-Maria Dittrich, Anna-Maria Dittrich   +26 more
doaj   +1 more source

Muco-Obstructive Lung Diseases

New England Journal of Medicine, 2019
A spectrum of lung diseases that affect the airways, including chronic obstructive pulmonary disease (COPD), cystic fibrosis, primary ciliary dyskinesia, and non–cystic fibrosis bronchiectasis, can be characterized as muco-obstructive diseases. These diseases have the clinical features of cough, sputum production, and episodic exacerbations that are ...
Boyton, RJ, Altmann, DM
openaire   +9 more sources

Polymerization of misfolded Z alpha-1 antitrypsin protein lowers CX3CR1 expression in human PBMCs

eLife, 2021
Expression levels of CX3CR1 (C-X3-C motif chemokine receptor 1) on immune cells have significant importance in maintaining tissue homeostasis under physiological and pathological conditions.
Srinu Tumpara, Matthias Ballmaier, Sabine Wrenger, Mandy König, Matthias Lehmann, Ralf Lichtinghagen, Beatriz Martinez-Delgado, Elena Korenbaum, David DeLuca, Nils Jedicke, Tobias Welte, Malin Fromme, Pavel Strnad, Jan Stolk, Sabina Janciauskiene   +14 more
doaj   +1 more source