Results 11 to 20 of about 275,740 (301)

Deep learning-based quantification of NAFLD/NASH progression in human liver biopsies

Scientific Reports, 2022
Non-alcoholic fatty liver disease (NAFLD) affects about 24% of the world's population. Progression of early stages of NAFLD can lead to the more advanced form non-alcoholic steatohepatitis (NASH), and ultimately to cirrhosis or liver cancer.
Fabian Heinemann, Peter Gross, Svetlana Zeveleva, Hu Sheng Qian, Jon Hill, Anne Höfer, Danny Jonigk, Anna Mae Diehl, Manal Abdelmalek, Martin C. Lenter, Steven S. Pullen, Paolo Guarnieri, Birgit Stierstorfer   +12 more
doaj   +1 more source

Cigarette Smoke Affects Dendritic Cell Populations, Epithelial Barrier Function, and the Immune Response to Viral Infection With H1N1

Frontiers in Medicine, 2020
Smokers with apparently “healthy” lungs suffer from more severe and frequent viral respiratory infections, but the mechanisms underlying this observation are still unclear.
Olga Danov, Martin Wolff, Sabine Bartel, Sabine Bartel, Sebastian Böhlen, Helena Obernolte, Sabine Wronski, Danny Jonigk, Barbara Hammer, Draginja Kovacevic, Sebastian Reuter, Sebastian Reuter, Susanne Krauss-Etschmann, Susanne Krauss-Etschmann, Katherina Sewald   +14 more
doaj   +1 more source

Guanylyl cyclase activation reverses resistive breathing–induced lung injury and inflammation [PDF]

, 2015
Inspiratory resistive breathing (RB), encountered in obstructive lung diseases, induces lung injury. The soluble guanylyl cyclase (sGC)/cyclic guanosine monophosphate (cGMP) pathway is down-regulated in chronic and acute animal models of RB, such as ...
Brouckaert, Peter, Dettoraki, Maria, Giannis, Athanassios, Glynos, Constantinos, Karavana, Vassiliki, Kotsikoris, Vasilis, Loverdos, Konstantinos, Magkou, Christina, Papapetropoulos, Andreas, Pavlidou, Athanasia, Perlikos, Fotis, Theocharis, Stamatios E, Topouzis, Stavros, Toumpanakis, Dimitris, Vassilakopoulos, Theodoros, Zhou, Zongmin   +15 more
core   +2 more sources

Acute Phase Proteins as Early Predictors for Immunotherapy Response in Advanced NSCLC: An Explorative Study

Frontiers in Oncology, 2022
In the last decade, targeting the immune system became a promising therapy in advanced lung cancer stages. However, in a clinical follow-up, patient responses to immune checkpoint inhibitors widely differ.
Marc A. Schneider, Marc A. Schneider, Adriana Rozy, Sabine Wrenger, Sabine Wrenger, Petros Christopoulos, Petros Christopoulos, Thomas Muley, Thomas Muley, Michael Thomas, Michael Thomas, Michael Meister, Michael Meister, Tobias Welte, Tobias Welte, Joanna Chorostowska-Wynimko, Sabina Janciauskiene, Sabina Janciauskiene, Sabina Janciauskiene   +18 more
doaj   +1 more source

Palliative care for people with non-malignant lung disease: summary of current evidence and future direction [PDF]

, 2013
Background: The physical and psychosocial needs of patients with chronic non-malignant lung disease are comparable to those with lung cancer. This article will focus on chronic obstructive pulmonary disease, interstitial lung disease and cystic fibrosis ...
Boland, Jason, Martin, Jonathan, Ross, Joy R, Ross, Joy R., Wells, Athol U, Wells, Athol U.   +5 more
core   +1 more source

Prevalence of asthma and COPD and blood eosinophil count in a middle-aged Belgian population [PDF]

, 2019
Various phenotypes exist in asthma and Chronic Obstructive Pulmonary Disease (COPD). These are important to identify in order to guide treatment decisions.
Brusselle, Guy, De Buyzere, Marc, Lahousse, Lies, Rietzschel, Ernst, Wijnant, Sara   +4 more
core   +1 more source

Volumetric Imaging of Lung Tissue at Micrometer Resolution: Clinical Applications of Micro-CT for the Diagnosis of Pulmonary Diseases

Diagnostics, 2021
Micro-computed tomography (micro-CT) is a promising novel medical imaging modality that allows for non-destructive volumetric imaging of surgical tissue specimens at high spatial resolution.
Andreana Bompoti, Andreas S. Papazoglou, Dimitrios V. Moysidis, Nikolaos Otountzidis, Efstratios Karagiannidis, Nikolaos Stalikas, Eleftherios Panteris, Vijayakumar Ganesh, Thomas Sanctuary, Christos Arvanitidis, Georgios Sianos, James S. Michaelson, Markus D. Herrmann   +12 more
doaj   +1 more source

The Multifaceted Effects of Alpha1-Antitrypsin on Neutrophil Functions

Frontiers in Pharmacology, 2018
Neutrophils are the predominant immune cells in human blood possessing heterogeneity, plasticity and functional diversity. The activation and recruitment of neutrophils into inflamed tissue in response to stimuli are tightly regulated processes.
Sabina Janciauskiene, Sabina Janciauskiene, Sabine Wrenger, Stephan Immenschuh, Beata Olejnicka, Timm Greulich, Tobias Welte, Joanna Chorostowska-Wynimko   +7 more
doaj   +1 more source

Acute and Chronic Effects of Smoking on Inflammation Markers in Exhaled Breath Condensate in Current Smokers [PDF]

, 2010
Background: Long-term cigarette smoking is associated with pulmonary inflammation, but the acute effects of smoking have been less well studied. Analysis of the exhaled breath condensate (EBC) can provide noninvasive markers that might be indicative of ...
Bals, Robert, Herr, Christian, Jörres, Rudolf A., Koczulla, A. Rembert, Noeske, Sarah, Römmelt, Horst, Vogelmeier, Claus   +6 more
core   +1 more source

Generation of two human induced pluripotent stem cell lines (MHHi017-A, MHHi017-B) from a patient with primary ciliary dyskinesia carrying a homozygous mutation (c.7915C > T [p.Arg2639*]) in the DNAH5 gene

Stem Cell Research, 2020
Dynein axonemal heavy chain 5 (DNAH5) is part of a microtubule-associated protein complex found within the cilia of the lung. Mutations in the DNAH5 gene lead to impaired ciliary function and are linked to primary ciliary dyskinesia (PCD), a rare ...
Nora Drick, Julia Dahlmann, Anais Sahabian, Alexandra Haase, Gudrun Göhring, Nico Lachmann, Felix C. Ringshausen, Tobias Welte, Ulrich Martin, Ruth Olmer   +9 more
doaj   +1 more source