Results 21 to 30 of about 254,670 (209)

Multifaceted Roles of Ferroptosis in Lung Diseases

Frontiers in Molecular Biosciences, 2022
Ferroptosis is a distinct type of programmed cell death (PCD) that depends on iron and is characterized by the accumulation of intracellular iron, exhaustion of glutathione, deactivation of glutathione peroxidase, and promotion of lipid peroxidation ...
Yi Li, Yi Li, Yi Li, Ying Yang, Ying Yang, Yongfeng Yang, Yongfeng Yang, Yongfeng Yang   +7 more
doaj   +1 more source

Unmet needs in pneumonia research: a comprehensive approach by the CAPNETZ study group

Respiratory Research, 2022
Introduction Despite improvements in medical science and public health, mortality of community-acquired pneumonia (CAP) has barely changed throughout the last 15 years.
Mathias W. Pletz, Andreas Vestergaard Jensen, Christina Bahrs, Claudia Davenport, Jan Rupp, Martin Witzenrath, Grit Barten-Neiner, Martin Kolditz, Sabine Dettmer, James D. Chalmers, Daiana Stolz, Norbert Suttorp, Stefano Aliberti, Wolfgang M. Kuebler, Gernot Rohde   +14 more
doaj   +1 more source

Deep learning-based quantification of NAFLD/NASH progression in human liver biopsies

Scientific Reports, 2022
Non-alcoholic fatty liver disease (NAFLD) affects about 24% of the world's population. Progression of early stages of NAFLD can lead to the more advanced form non-alcoholic steatohepatitis (NASH), and ultimately to cirrhosis or liver cancer.
Fabian Heinemann, Peter Gross, Svetlana Zeveleva, Hu Sheng Qian, Jon Hill, Anne Höfer, Danny Jonigk, Anna Mae Diehl, Manal Abdelmalek, Martin C. Lenter, Steven S. Pullen, Paolo Guarnieri, Birgit Stierstorfer   +12 more
doaj   +1 more source

Elastocapillary network model of inhalation [PDF]

Physical Review Research, 2, 043382 (2020), 2020
The seemingly simple process of inhalation relies on a complex interplay between muscular contraction in the thorax, elasto-capillary interactions in individual lung branches, propagation of air between different connected branches, and overall air flow into the lungs.
arxiv   +1 more source

Cigarette Smoke Affects Dendritic Cell Populations, Epithelial Barrier Function, and the Immune Response to Viral Infection With H1N1

Frontiers in Medicine, 2020
Smokers with apparently “healthy” lungs suffer from more severe and frequent viral respiratory infections, but the mechanisms underlying this observation are still unclear.
Olga Danov, Martin Wolff, Sabine Bartel, Sabine Bartel, Sebastian Böhlen, Helena Obernolte, Sabine Wronski, Danny Jonigk, Barbara Hammer, Draginja Kovacevic, Sebastian Reuter, Sebastian Reuter, Susanne Krauss-Etschmann, Susanne Krauss-Etschmann, Katherina Sewald   +14 more
doaj   +1 more source

Acute Phase Proteins as Early Predictors for Immunotherapy Response in Advanced NSCLC: An Explorative Study

Frontiers in Oncology, 2022
In the last decade, targeting the immune system became a promising therapy in advanced lung cancer stages. However, in a clinical follow-up, patient responses to immune checkpoint inhibitors widely differ.
Marc A. Schneider, Marc A. Schneider, Adriana Rozy, Sabine Wrenger, Sabine Wrenger, Petros Christopoulos, Petros Christopoulos, Thomas Muley, Thomas Muley, Michael Thomas, Michael Thomas, Michael Meister, Michael Meister, Tobias Welte, Tobias Welte, Joanna Chorostowska-Wynimko, Sabina Janciauskiene, Sabina Janciauskiene, Sabina Janciauskiene   +18 more
doaj   +1 more source

Volumetric Imaging of Lung Tissue at Micrometer Resolution: Clinical Applications of Micro-CT for the Diagnosis of Pulmonary Diseases

Diagnostics, 2021
Micro-computed tomography (micro-CT) is a promising novel medical imaging modality that allows for non-destructive volumetric imaging of surgical tissue specimens at high spatial resolution.
Andreana Bompoti, Andreas S. Papazoglou, Dimitrios V. Moysidis, Nikolaos Otountzidis, Efstratios Karagiannidis, Nikolaos Stalikas, Eleftherios Panteris, Vijayakumar Ganesh, Thomas Sanctuary, Christos Arvanitidis, Georgios Sianos, James S. Michaelson, Markus D. Herrmann   +12 more
doaj   +1 more source

Systematic Review of Exposure to Polycyclic Aromatic Hydrocarbons and Obstructive Lung Disease [PDF]

Journal of Health and Pollution, 2021
Background. There is fast-growing epidemiologic evidence of the effects of environmental chemicals on respiratory health. Polycyclic aromatic hydrocarbons (PAHs) have been linked with airway obstruction common in asthma and/or asthma exacerbation, and ...
Chinemerem C. Nwaozuzu, Kingsley C. Partick-Iwuanyanwu, Stephen O. Abah   +2 more
doaj   +1 more source

The Multifaceted Effects of Alpha1-Antitrypsin on Neutrophil Functions

Frontiers in Pharmacology, 2018
Neutrophils are the predominant immune cells in human blood possessing heterogeneity, plasticity and functional diversity. The activation and recruitment of neutrophils into inflamed tissue in response to stimuli are tightly regulated processes.
Sabina Janciauskiene, Sabina Janciauskiene, Sabine Wrenger, Stephan Immenschuh, Beata Olejnicka, Timm Greulich, Tobias Welte, Joanna Chorostowska-Wynimko   +7 more
doaj   +1 more source

Estimating Total Lung Volume from Pixel-level Thickness Maps of Chest Radiographs Using Deep Learning [PDF]

Radiol Artif Intell. Published online May 28, 2025, 2021
Purpose: To estimate the total lung volume (TLV) from real and synthetic frontal chest radiographs (CXR) on a pixel level using lung thickness maps generated by a U-Net deep learning model. Methods: This retrospective study included 5,959 chest CT scans from two public datasets: the lung nodule analysis 2016 (n=656) and the Radiological Society of ...
arxiv   +1 more source