Results 81 to 90 of about 1,682,964 (357)

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

Chitotriosidase: a biomarker of activity and severity in patients with sarcoidosis

Respiratory Research, 2020
Background Serum chitotriosidase is a promising biomarker that has shown high specificity and sensitivity in patients with sarcoidosis. The aim of this study was to investigate correlations between serum chitotriosidase, clinical phenotypes, disease ...
David Bennett, Paolo Cameli, Nicola Lanzarone, Loredana Carobene, Nicola Bianchi, Annalisa Fui, Luigi Rizzi, Laura Bergantini, Giuseppe Cillis, Miriana d’Alessandro, Maria Antonietta Mazzei, Rosa Metella Refini, Piersante Sestini, Elena Bargagli, Paola Rottoli   +14 more
doaj   +1 more source

COVID-19, A New Possible Mimicker of Interstitial Lung Disease Related to Primary Sjögren’s Syndrome

Case Reports in Medicine, 2023
Introduction. Acute exacerbation of interstitial lung disease (ILD) and COVID-19 pneumonia show many similarities, but also COVID-19 sequelae, mainly when fibrotic features are present, can be difficult to distinguish from chronic ILD observed in ...
Alessia Laneri, Stefania Cerri, Giovanni Della Casa, Antonio Moretti, Andreina Manfredi, Marco Sebastiani, Enrico Clini, Carlo Salvarani   +7 more
doaj   +1 more source

Use of a FluoroType^® System for the Rapid Detection of Patients with Multidrug-Resistant Tuberculosis—State of the Art Case Presentations

Diagnostics, 2022
According to the World Health Organization (WHO), there were 465,000 cases of tuberculosis caused by strains resistant to at least two first-line anti-tuberculosis drugs: rifampicin and isoniazid (MDR-TB).
Anna Zabost, Dorota Filipczak, Włodzimierz Kupis, Monika Szturmowicz, Łukasz Olendrzyński, Agnieszka Winiarska, Jacek Jagodziński, Ewa Augustynowicz-Kopeć   +7 more
doaj   +1 more source

The Impact of HAART on the Respiratory Complications of HIV Infection: Longitudinal Trends in the MACS and WIHS Cohorts [PDF]

, 2013
Objective: To review the incidence of respiratory conditions and their effect on mortality in HIV-infected and uninfected individuals prior to and during the era of highly active antiretroviral therapy (HAART).
A Johannessen, A Lindberg, AK Chaturvedi, Alison Morris, AN Phillips, B Balbi, BR Celli, Charles R. Rinaldo, Christine B. Alden, DB Coultas, E Gouws, EA Engels, EC Seaberg, Eric C. Kleerup, Eric C. Seaberg, F Gutin, FJ Palella Jr, FN Engsig, G. K. Balasubramani, GA D’Jaen, GD Kirk, GM Allardice, GM Clifford, J Almirall, Jason F. Okulicz, JE Kaplan, JF Murray, JM Wallace, John Phair, Joseph B. Margolick, JR Grubb, K Crothers, K Crothers, K Crothers, K Sigel, L Dal Maso, Laurence Huang, Lawrence Kingsley, M Bower, M Frisch, M Herida, Matthew R. Gingo, MR Gingo, MR Gingo, MS Shiels, NA Hessol, Nancy A. Hessol, O Sitbon, PY Hsue, R McKenzie, RA Kaslow, RD Moore, RE Hirschtick, RM Phelps, Roger Detels, Ruth M. Greenblatt, S Hariri, Sarah H. Sutton, SB Foster, SE Barkan, Stephen R. Wisniewski, Susan Holman, T Takahashi, V Dufour   +63 more
core   +3 more sources

Expression and DNA methylation of 20S proteasome subunits as prognostic and resistance markers in cancer

Molecular Oncology, EarlyView.
Comprehensive analysis of genomic mutations, gene expression, DNA methylation, and pathway analysis of TCGA data was carried out to define cancer types in which proteasome subunits expression is associated with worse survival. Albeit the effect of specific proteasome subunits on cellular function, the main role of the proteasome is better evaluated ...
Ruba Al‐Abdulla, Simone Venz, Ruslan Al‐Ali, Martin Wendlandt, Mandy Radefeldt, Elke Krüger   +5 more
wiley   +1 more source

Correction to: Chitotriosidase: a biomarker of activity and severity in patients with sarcoidosis

Respiratory Research, 2020
After publication of our article [1] the authors have notified us that one of the names has been incorrectly tagged.
David Bennett, Paolo Cameli, Nicola Lanzarone, Loredana Carobene, Nicola Bianchi, Annalisa Fui, Luigi Rizzi, Laura Bergantini, Giuseppe Cillis, Miriana d’Alessandro, Maria Antonietta Mazzei, Rosa Metella Refini, Piersante Sestini, Elena Bargagli, Paola Rottoli   +14 more
doaj   +1 more source

Self-proning in COVID-19 patients on low-flow oxygen therapy: a cluster randomised controlled trial

ERJ Open Research, 2021
Rationale and objectives Prone positioning as a complement to oxygen therapy to treat hypoxaemia in coronavirus disease 2019 (COVID-19) pneumonia in spontaneously breathing patients has been widely adopted, despite a lack of evidence for its benefit.
Aileen Kharat, Elise Dupuis-Lozeron, Chloé Cantero, Christophe Marti, Olivier Grosgurin, Sanaz Lolachi, Frédéric Lador, Jérôme Plojoux, Jean-Paul Janssens, Paola M. Soccal, Dan Adler   +10 more
doaj   +1 more source

Lung Regeneration: Endogenous and Exogenous Stem Cell Mediated Therapeutic Approaches [PDF]

, 2016
The tissue turnover of unperturbed adult lung is remarkably slow. However, after injury or insult, a specialised group of facultative lung progenitors become activated to replenish damaged tissue through a reparative process called regeneration ...
Adamson, Adamson, Adamson, Akram, Akram, Alcorn, Ang, Ayers, Baber, Bellusci, Bellusci, Bogue, Bowden, Boyden, Boyden, Bruno, Chapman, Chinoy, Danchuk, Davidson, Deutsch, Dunsmore, Evans, Guazzi, Guo, Hackett, Isakson, Kauffman, Kauffman, Kaza, Kelly, Khondoker Akram, Kotton, Kreis, Langston, Lazzaro, Leeman, Lomas, Loosli, Mason, McKeehan, Monaghan, Monica Spiteri, Neil Patel, Nicholas Forsyth, Nogawa, Plopper, Potten, Shannon, Takahashi, Warburton, Weaver, Weinstein, Yano   +53 more
core   +3 more sources

Data‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes

Molecular Oncology, EarlyView.
This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh, Nikola Tom, Anna Schrøder Lassen, Helene Brasch Lind Petersen, Ulrik Kristoffer Stoltze, Karin Wadt, Kjeld Schmiegelow, Matteo Tiberti, Elena Papaleo   +8 more
wiley   +1 more source