Results 1 to 10 of about 612,400 (156)

MYC is a metastasis gene for non-small-cell lung cancer. [PDF]

, 2009
Metastasis is a process by which cancer cells learn to form satellite tumors in distant organs and represents the principle cause of death of patients with solid tumors. NSCLC is the most lethal human cancer due to its high rate of metastasis.
Castro, Inês, Ceteci, Fatih, Karreman, Christiaan, Korn, Christian, Luetkenhaus, Katharina, Potapenko, Tamara, Rapp, Ulf R., Serafin, Valentina, Zanucco, Emanuele   +8 more
core   +16 more sources

Identification of multiple organ metastasis-associated hub mRNA/miRNA signatures in non-small cell lung cancer

Cell Death and Disease, 2023
Metastasis remains major cause of treatment failure in non-small cell lung cancer (NSCLC). A comprehensive characterization of the transcriptomic landscape of NSCLC-cells with organ-specific metastatic potentials would advance our understanding of NSCLC ...
Lingling Zu, Jinling He, Ning Zhou, Quanying Tang, Maoli Liang, Song Xu   +5 more
doaj   +1 more source

Autophagic secretion of HMGB1 from cancer-associated fibroblasts promotes metastatic potential of non-small cell lung cancer cells via NFκB signaling

Cell Death and Disease, 2021
Tumor progression requires the communication between tumor cells and tumor microenvironment (TME). Cancer-associated fibroblasts (CAFs) are major components of stromal cells.
Yinghui Ren, Limin Cao, Limin Wang, Sijia Zheng, Qicheng Zhang, Xueru Guo, Xueqin Li, Mengmeng Chen, Xiang Wu, Fiona Furlong, Zhaowei Meng, Ke Xu   +11 more
doaj   +1 more source

MiR‐192/NKRF axis confers lung cancer cell chemoresistance to cisplatin via the NF‐κB pathway

Thoracic Cancer, 2022
Background Chemoresistance influences the therapeutic effect of cisplatin and remains a major obstacle to its clinical use. MicroRNAs are associated with drug resistance of various tumors.
Yang Li, Lingling Zu, Heng Wu, Fang Zhang, Yaguang Fan, Hongli Pan, Xinxin Du, Fengjie Guo, Qinghua Zhou   +8 more
doaj   +1 more source

Inhibition of spontaneous and experimental lung metastasis of soft-tissue sarcoma by tumor-targeting Salmonella typhimurium A1-R. [PDF]

, 2014
Prognosis of patients with lung metastases of soft-tissue sarcoma is still poor. Therefore, novel systemic therapy is needed to improve the survival of soft-tissue sarcoma.
Baek, Kyung-Eun, Bouvet, Michael, Hayashi, Katsuhiro, Hiroshima, Yukihiko, Hoffman, Robert M, Kimura, Hiroaki, Matsumoto, Yasunori, Miwa, Shinji, Tsuchiya, Hiroyuki, Uehara, Fuminari, Yamamoto, Mako, Yamamoto, Norio, Yano, Shuya, Zhang, Yong, Zhao, Ming   +14 more
core   +6 more sources

Lung Cancer Stem-like Cells and Drug Resistance

Chinese Journal of Lung Cancer, 2022
Lung cancer remains the leading cause of cancer-related death world-wide. Therapy resistance and relapse are considered major reasons contributing to the poor survival rates of lung cancer.
Zhenhua PAN, Hongyu LIU, Jun CHEN
doaj   +1 more source

Caveolin-1 is a risk factor for postsurgery metastasis in preclinical melanoma models [PDF]

, 2014
Melanomas are highly lethal skin tumours that are frequently treated by surgical resection. However, the efficacy of such procedures is often limited by tumour recurrence and metastasis. Caveolin-1 (CAV1) has been attributed roles as a tumour suppressor,
Aguilar-Guzmán, L, Bennett, DC, Bieneck, S, Burzio, V, Fernandez, JG, Hossain, M, Leyton, L, Lobos-Gonzalez, L, Muñoz, N, Quest, AF, Silva, V, Sviderskaya, EV   +11 more
core   +2 more sources

Research Progress of Epigenetics in Pathogenesis and Treatment of Malignant Tumors

Chinese Journal of Lung Cancer, 2020
Epigenetic modification is closely related to the occurrence and development of tumors. It mainly regulates gene function and expression level through DNA methylation, histone modification, regulation of non-coding RNA and chromatin structure ...
Pan WANG, Honglin ZHAO, Fan REN, Qingchun ZHAO, Ruifeng SHI, Xingyu LIU, Jinghao LIU, Yongwen LI, Ying LI, Hongyu LIU, Jun CHEN   +10 more
doaj   +1 more source

Symptom trajectories during chemotherapy in patients with non‐small cell lung cancer (NSCLC) and the function of prolonging low dose dexamethasone in promoting enhanced recovery after chemotherapy

Thoracic Cancer, 2021
Background Lung cancer, mainly non‐small cell lung cancer (NSCLC), is one of the leading causes of death worldwide. Currently, chemotherapy is still the most significant treatment strategy for NSCLC.
Jinghao Liu, Xingyu Liu, Ming Dong, Honglin Zhao, Mei Li, Hongbing Zhang, Huihui Ji, Yi Shi, Yajie Cui, Di Wu, Gang Chen, Jun Chen   +11 more
doaj   +1 more source

CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis [PDF]

, 2011
Macrophages abundantly found in the tumor microenvironment enhance malignancy(1). At metastatic sites a distinct population of metastasis associated macrophages (MAMs) promote tumor cell extravasation, seeding and persistent growth(2).
AB Al-Mehdi, AD Borowsky, AJ Minn, AM Havens, B Brandt, B Qian, Bin-Zhi Qian, BS Nielsen, DR Getts, DR Rhodes, Elizabeth A. Kaiser, F Geissmann, F Geissmann, F Geissmann, FK Swirski, H Saji, HP Gerber, Hui Zhang, Jeffrey W. Pollard, JH Im, Jinghang Zhang, Jiufeng Li, JM Carton, Liam R. Campion, Linda A. Snyder, MD Abramoff, P Stern, P Tsui, RT Palframan, T Ueno, T Valkovic, Takanori Kitamura, Y Huang   +32 more
core   +5 more sources