Results 41 to 50 of about 444,704 (269)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Meta-analysis of the Association between RASSF1A Gene 
Promoter Methylation and Non-small Cell Lung Cancer

Chinese Journal of Lung Cancer, 2015
Background and objective The CpG island aberrant promoter methylation in the tumor suppressor gene region plays an important role in the process of tumorigenesis.
Huijun WEI, Nianzhen FANG, Lili GUO, Zhihao WU, Qinghua ZHOU   +4 more
doaj   +1 more source

Characteristics of the immune microenvironment and their clinical significance in non-small cell lung cancer patients with ALK-rearranged mutation

Frontiers in Immunology, 2022
BackgroundAlthough immune checkpoint inhibitors (ICIs) are one of the most important treatments for advanced-stage non-small-cell lung cancer (NSCLC), NSCLC patients with ALK-rearranged usually don’t obtain a clinical benefit.
Bo Zhang, Bo Zhang, Jingtong Zeng, Jingtong Zeng, Hao Zhang, Hao Zhang, Shuai Zhu, Shuai Zhu, Hanqing Wang, Hanqing Wang, Jinling He, Jinling He, Lingqi Yang, Lingqi Yang, Ning Zhou, Ning Zhou, Lingling Zu, Lingling Zu, Xiaohong Xu, Zuoqing Song, Zuoqing Song, Song Xu, Song Xu   +22 more
doaj   +1 more source

Lung Adenocarcinoma with Gingival Metastasis

European Journal of Case Reports in Internal Medicine, 2018
Gingival metastasis of lung cancer is uncommon. We report the case of an 82-year-old male smoker admitted to the pulmonology department with right pleural effusion. A chest computed tomography (CT) scan showed an invasive right hilar tumour, adherent to the superior vena cava, pulmonary artery, main right bronchus, mediastinal pleura and pericardium ...
Gargouri, Imen, Hergli, Benzarti Wafa, Aissa, Sana, Kanoun-Belajouza, Samia, Hayouni, Abdelaziz, Garrouche, Abdelhamid, Abdelghani, Ahmed, Benzarti, Mohamed   +7 more
openaire   +4 more sources

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Neutrophil infiltration associated genes on the prognosis and tumor immune microenvironment of lung adenocarcinoma

Frontiers in Immunology, 2023
The neutrophils exhibit both anti-tumor and pro-tumor effects in cancers. The correlation between neutrophils and tumor development in lung adenocarcinoma (LUAD) is still uncertain, possibly due to a lack of specific neutrophil infiltration evaluation ...
Renwang Liu, Renwang Liu, Guangsheng Zhu, Guangsheng Zhu, Yonglin Sun, Mingbiao Li, Zixuan Hu, Zixuan Hu, Peijun Cao, Peijun Cao, Xuanguang Li, Xuanguang Li, Zuoqing Song, Zuoqing Song, Jun Chen, Jun Chen   +15 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

The Expression of RTN1 in Lung Adenocarcinoma and 
Its Effect on Immune Microenvironment

Chinese Journal of Lung Cancer, 2022
Background and objective Reticulosome family gene 1 (RTN1) is a reticulosome-encoding gene associated with the endoplasmic reticulum. RTN1 plays a key role in membrane trafficking or neuroendocrine secretion of neuroendocrine cells, while RTN1 serves as ...
Shuai ZHU, Lingling ZU, Song XU
doaj   +1 more source

[A patient with lung metastasis of medulloblastoma].

Nihon Kyobu Shikkan Gakkai zasshi, 1996
A 15-year-old boy had metastasis to the spinal cord and then to the lung after an operation to remove a primary medulloblastoma. A medulloblastoma developed at the age of 10 years. The tumor was completely resected and the brain and spinal cord were irradiated.
Naitoh, Tatsuo, Matsushita, Kanehiro, Asai, Yasuyuki, Suetsugu, Susumu   +3 more
openaire   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source