Results 21 to 30 of about 444,704 (269)

Research Advances of m6A RNA Methylation in Non-small Cell Lung Cancer

Chinese Journal of Lung Cancer, 2020
N6-methyladenosine is one of the most prevalent mRNA modification in eukaryotes. The regulation of this pervasive mark is a dynamic and reversible process.
Hongli PAN, Xuebing LI, Chen CHEN, Yaguang FAN, Qinghua ZHOU   +4 more
doaj   +1 more source

Construction of a circular RNA–microRNA–messenger RNA regulatory network of hsa_circ_0043256 in lung cancer by integrated analysis

Thoracic Cancer, 2022
Background Patients with non‐small cell lung cancer (NSCLC) are diagnosed in advanced stages and with a poor 5‐year survival rate. There is a critical need to identify novel biomarkers to improve the therapy and overall prognosis of this disease. Methods
Yongwen Li, Ruifeng Shi, Guangsheng Zhu, Chen Chen, Hua Huang, Min Gao, Songlin Xu, Peijun Cao, Zihe Zhang, Di Wu, Xuanguang Li, Hongyu Liu, Jun Chen   +12 more
doaj   +1 more source

PD‐0332991 combined with cisplatin inhibits nonsmall cell lung cancer and reversal of cisplatin resistance

Thoracic Cancer, 2021
Background: Acquired resistance of chemotherapy, especially cisplatin, is a major challenge in lung cancer treatment. We conducted this study to examine whether a cyclin D kinase 4/6 (CDK4/6) inhibitor, PD 0332991, could reverse cisplatin resistance in ...
Minghui Liu, Liyuan Cui, Xin Li, Chunqiu Xia, Yongwen Li, Rui Wang, Fan Ren, Hongyu Liu, Jun Chen   +8 more
doaj   +1 more source

Cancer-Associated Fibroblasts Promote Migration and Invasion of Non-Small Cell Lung Cancer Cells via miR-101-3p Mediated VEGFA Secretion and AKT/eNOS Pathway

Frontiers in Cell and Developmental Biology, 2021
Cancer-associated fibroblasts (CAFs) are major component of tumor microenvironment (TME), which plays crucial roles in tumor growth, invasion and metastasis; however, the underling mechanism is not fully elucidated.
Xueru Guo, Mengmeng Chen, Limin Cao, Yiming Hu, Xueqin Li, Qicheng Zhang, Yinghui Ren, Xiang Wu, Zhaowei Meng, Ke Xu   +9 more
doaj   +1 more source

Progression and metastasis of lung cancer [PDF]

Cancer and Metastasis Reviews, 2016
Metastasis in lung cancer is a multifaceted process. In this review, we will dissect the process in several isolated steps such as angiogenesis, hypoxia, circulation, and establishment of a metastatic focus. In reality, several of these processes overlap and occur even simultaneously, but such a presentation would be unreadable.
openaire   +2 more sources

Validation of stage groupings in the eighth edition of the tumor node metastasis classification for lung adenocarcinoma

Thoracic Cancer, 2019
Background The purpose of this study was to validate stage groupings in the 8th edition of the tumor node metastasis (TNM) classification for lung adenocarcinoma and explore the non‐anatomic factors that influence the prognosis of lung adenocarcinoma ...
Wenguan Yu, Qingchun Zhao, Chunqiu Xia, Ming Dong, Jinghao Liu, Xin Li, Honglin Zhao, Gang Chen, Hongyu Liu, Jun Chen   +9 more
doaj   +1 more source

Lymph node metastasis in lung squamous cell carcinoma and identification of metastasis‐related genes based on the Cancer Genome Atlas

Cancer Medicine, 2019
Squamous cell carcinoma (SCC) is a unique clinical and histological category that accounts for about 30% of total lung cancer. To identify risk factors for lymph node metastasis and analyze the molecular features of these metastases in lung SCC, a ...
Ming Dong, Hao Gong, Tong Li, Xin Li, Jinghao Liu, Hongbing Zhang, Minghui Liu, Gang Chen, Hongyu Liu, Jun Chen   +9 more
doaj   +1 more source

Expression and Significance of IKBKB in Pulmonary Adenocarcinoma A549 Cells and Its Cisplatin-resistant Variant A549/DDP

Chinese Journal of Lung Cancer, 2014
Background and objective Cisplatin-resistance in Lung cancer cells is widespread in the clinical treatment, seriously affecting the effects of the treatment of lung cancer.
Kang QI, Yang LI, Xuebing LI, Fang ZHANG, Yi SHAO, Qinghua ZHOU   +5 more
doaj   +1 more source

Clinical Value of Seven Autoantibodies Against Tumor-Associated Antigens and Tumor Markers in Lung Cancer Patients: A Retrospective Analysis from a Single Institution

Technology in Cancer Research & Treatment
Background: Lung cancer screening is not limited to low dose computed tomography (LDCT). Recently, molecular biomarkers have been shown to have the potential to improve the current state of early lung cancer detection.
Fan Ren MD, Feng Chen MM, Xiaoqian Xu MM, Hong Ni MM, Tong Li MM, Dian Ren MM, Zuoqing Song MD, Gang Chen BM, Jun Chen MD, Song Xu MD   +9 more
doaj   +1 more source

Clinical Significance and Next-Generation Sequencing of Chinese Pulmonary Sarcomatoid Carcinoma

Scientific Reports, 2017
Pulmonary Sarcomatoid Carcinoma (PSC) constitutes a heterogeneous group of non-small-cell lung carcinomas (NSCLCs) with a poor prognosis. In this study, a group of 7 patients with PSC was studied. Microscope analysis of all 7 cases revealed a pleomorphic
Xin Li, Dan Wang, Qingchun Zhao, Dian Ren, Fan Ren, Gang Chen, Hongyu Liu, Jun Chen   +7 more
doaj   +1 more source