Results 91 to 100 of about 355,907 (356)

Suppressing t(4;11) Acute Leukemia by Lipopolymer Nanoparticle Delivery of siRNA Targeting KMT2A::AFF1 with Enhanced Extrahepatic Delivery

Advanced Healthcare Materials, EarlyView.
This study introduces a new lipopolymer nanoparticle (LPNP) system that efficiently delivers siRNA to leukemia cells. The LPNPs silence the leukemia fusion gene KMT2A::AFF1, induce apoptosis, and decrease leukemia burden in mice. These results demonstrate the potential of LPNPs as a targeted siRNA therapy for acute lymphoblastic leukemia.
Mohammad Nasrullah, Remant KC, Amarnath Praphakar Rajendran, Saba Abbasi Dezfouli, Cezary Kucharski, Xiaoyan Jiang, Spencer B. Gibson, Joseph Brandwein, Olaf Heidenreich, Hasan Uludağ   +9 more
wiley   +1 more source

Clinical trial of FK 506 immunosuppression in adult cardiac transplantation [PDF]

, 1992
The new immunosuppressive agent FK 506 was used as primary immunotherapy in conjunction with low-dose steroids and azathioprine in 72 patients subsequent to orthotopic cardiac transplantation.
Armitage, Bartley P. Griffith, Billingham, Dew, Fung, Gary C. Marrone, John Fung, John M. Armitage, Kormos, Kusne, Robert L. Hardesty, Robert L. Kormos, Shigeki Morita, Starzl, Starzl, Tamura, Thomas E. Starzl, Todo   +17 more
core   +1 more source

Mitochondrial Transplantation via Magnetically Responsive Artificial Cells Promotes Intracerebral Hemorrhage Recovery by Supporting Microglia Immunological Homeostasis

Advanced Materials, Volume 37, Issue 13, April 2, 2025.
A type of magnetically responsive artificial cells (ACs) has been developed, demonstrating the loading of mitochondria and self‐enclosure processes to ensure the protection of mitochondrial transport via the bloodstream. The treatment with ACs effectively transplanted mitochondria around the lesion, thereby improving neurological recovery by supporting
Mi Zhou, Jinhui Zang, Yuxuan Qian, Qiang Zhang, Yifan Wang, Tingting Yao, Hongyu Yan, Kai Zhang, Xiaojun Cai, Lixian Jiang, Yuanyi Zheng   +10 more
wiley   +1 more source

Asymptomatic Giant Lipoma of the Right Ventricular Outflow Tract: A Case Report

Journal of Tehran University Heart Center, 2017
Cardiac lipomas are extremely rare tumors of the heart. They are usually symptomatic and rarely may be found incidentally in autopsies. Here we describe a 23-year-old healthy man, in whose physical examination for employment a murmur was found ...
Fariba Bayat, Zargham Hossein Ahmadi, Neda Behzadnia, Atosa Dorudinia, Alireza Jahangirifard   +4 more
doaj  

Airway epithelium in lung transplantation: a potential actor for post-transplant complications?

European Respiratory Review
Lung transplantation, a critical intervention for end-stage lung diseases, is frequently challenged by post-transplant complications. Indeed, primary graft dysfunction, anastomotic complications, infections and acute and chronic rejections pose ...
Jules Milesi, Delphine Gras, Pascal Chanez, Benjamin Coiffard   +3 more
doaj   +1 more source

Biomimetic 3D‐Printed Adaptive Hydrogel Bioadhesives Featuring Superior Infection Resistance for Challenging Tissue Adhesion, Hemostasis, and Healthcare

Advanced Materials, EarlyView.
Biomimetic 3D‐printed hydrogel bioadhesives (PTLAs) are designed to address the limitations of existing bioadhesives, offering solutions for challenging tissue adhesion and enhanced healthcare. These PTLAs feature robust wet/underwater tissue adhesion/sealing, superior freeze/pressure and infection resistance, and adaptive self‐healing/gelling capacity,
Qi Wu, Meenakshi Chauhan, Bassma Khamaisi, Eid Nassar‐Marjiya, Shady Farah   +4 more
wiley   +1 more source

An integrated strategy for reducing anastomotic leakage in patients undergoing McKeown esophagectomy

Heliyon
Objective: To describe our experience of reducing anastomotic leakage, a problem that has not been properly solved. Methods: Starting in January 2020, we began implementing our integrated strategy (application of an esophageal diameter-approximated ...
Yan Zhang, Junya Wang, Shuang Ren, Jia Jiao, Zheng Ding, Hang Yang, Dabo Pan, Jindong Li, Guoqing Zhang, Xiangnan Li, Song Zhao   +10 more
doaj   +1 more source

Future Frontiers in Bioinspired Implanted Biomaterials

Advanced Materials, EarlyView.
Gu et al. present an integrative overview of cutting‐edge strategies in bioinspired implantable biomaterials for organ regeneration, highlighting how emerging approaches—including 3D bioprinting, scaffold design, hydrogel systems, surface modification, nanofiber engineering, and genetic manipulation—converge to restore structure and function across ...
Qi Gu, Rui Yuan, Dadi Sun, Gordon Wallace   +3 more
wiley   +1 more source

Kidney after nonrenal transplantation-the impact of alemtuzumab induction [PDF]

, 2009
BACKGROUND.: Calcineurin inhibitor nephrotoxicity in nonrenal allograft recipients can lead to end-stage renal disease and the need for kidney transplantation. We sought to evaluate the role of alemtuzumab induction in this population.
Amit Basu, Calne, Claire Morgan, Deanna Blisard, Demetrius Ellis, Eghtesad, Geoffrey Kurland, George Mazariegos, Henkie P. Tan, Igor Dvorchik, J Wallis Marsh, Jerry McCauley, Kareem Abu-Elmagd, Kenneth R. McCurry, Kirk, Knechtle, Ojo, Parmjeet S. Randhawa, Ron Shapiro, Shapiro, Shapiro, Shapiro, Steven Webber, Stuart, Tan, Thomas E. Starzl, Vivek Sharma, Waldmann   +27 more
core   +1 more source

Lung Transplantation: Technical Problems [PDF]

, 1964
John Borrie, Ivan Lichter
openalex   +1 more source