Studies on synthetic LuxR solo hybrids [PDF]
Frontiers in Cellular and Infection Microbiology, 2015 A sub-group of LuxR family of proteins that plays important roles in quorum sensing, a process of cell-cell communication, is widespread in proteobacteria.
Daniel ePassos da Silva +8 more
doaj +6 more sources
Directed Evolution of the Transcriptional Activator LuxR [PDF]
Journal of Bioscience and Bioengineering, 2006 LuxR-type proteins are responsible for density-dependent transcriptional regulation in quorum-sensing systems that employ acyl-homoserine lactones (acyl-HSLs) as signal molecules. The Vibrio fischeri lux operon, which includes LuxR, has been well studied and shown to function in E. coli.
Yuki Kimura +4 more
core +6 more sources
Genomic characterization of bacteria from the ultra-oligotrophic Madison aquifer: insight into the archetypical LuxI/LuxR and identification of novel LuxR solos [PDF]
BMC Research Notes, 2021 Objectives To characterize the bacterial community of Wind Cave’s Madison aquifer through whole-genome sequencing, and to better understand the bacterial ecology by identifying genes involved in acyl-homoserine lactone (AHL) based quorum-sensing (QS ...
Peter C. Wengert +5 more
doaj +3 more sources
The Vibrio fischeri LuxR protein is capable of bidirectional stimulation of transcription and both positive and negative regulation of the luxR gene [PDF]
Journal of Bacteriology, 1991 Regulation of the genes required for bioluminescence in the marine bacterium Vibrio fischeri (the lux regulon) is a complex process requiring coordination of several systems. The primary level of regulation is mediated by a positive regulatory protein, LuxR, and a small diffusible molecule, N-(3-oxo-hexanoyl)-homoserine lactone, termed autoinducer ...
G S, Shadel, T O, Baldwin
openaire +4 more sources
Modeling Analysis of Signal Sensitivity and Specificity by Vibrio fischeri LuxR Variants. [PDF]
PLoS ONE, 2015 The LuxR protein of the bacterium Vibrio fischeri belongs to a family of transcriptional activators that underlie pheromone-mediated signaling by responding to acyl-homoserine lactones (-HSLs) or related molecules. V. fischeri produces two acyl-HSLs, N-3-
Deanna M Colton +2 more
doaj +3 more sources
A walk into the LuxR regulators of Actinobacteria: phylogenomic distribution and functional diversity. [PDF]
PLoS ONE, 2012 LuxR regulators are a widely studied group of bacterial helix-turn-helix (HTH) transcription factors involved in the regulation of many genes coding for important traits at an ecological and medical level.
Catarina Lopes Santos +3 more
doaj +5 more sources
AphA and LuxR/HapR reciprocally control quorum sensing in vibrios [PDF]
Genes & Development, 2011 Bacteria cycle between periods when they perform individual behaviors and periods when they perform group behaviors. These transitions are controlled by a cell–cell communication process called quorum sensing, in which extracellular signal molecules, called autoinducers (AIs), are released, accumulate, and are synchronously detected by a group of ...
Steven T, Rutherford +3 more
openaire +4 more sources
Autoinducer-fluorophore conjugates enable FRET in LuxR proteins in vitro and in cells [PDF]
Nature Chemical Biology, 2022 Cell-to-cell signaling, or quorum sensing (QS), in Gram-negative bacteria is governed by small molecule signals (N-acyl L-homoserine lactones, AHLs) and their cognate intracellular receptors (LuxR-type proteins). The mechanistic underpinnings of QS in these bacteria are severely limited due to the challenges of isolating and manipulating most LuxR-type
Matthew J. Styles +6 more
openaire +4 more sources
Computational Exploration of Putative LuxR Solos in Archaea and Their Functional Implications in Quorum Sensing [PDF]
Frontiers in Microbiology, 2017 LuxR solos are unexplored in Archaea, despite their vital role in the bacterial regulatory network. They assist bacteria in perceiving acyl homoserine lactones (AHLs) and/or non-AHLs signaling molecules for establishing intraspecies, interspecies, and ...
Akanksha Rajput, Manoj Kumar
doaj +3 more sources
Interkingdom Signaling of the Insect Pathogen Photorhabdus luminescens with Plants Via the LuxR solo SdiA [PDF]
Microorganisms, 2023 In bacteria, group-coordinated behavior such as biofilm formation or virulence are often mediated via cell–cell communication, a process referred to as quorum sensing (QS). The canonical QS system of Gram-negative bacteria uses N-acyl homoserine lactones
Nazzareno Dominelli +3 more
doaj +2 more sources