Results 11 to 20 of about 11,555 (204)

Studies on synthetic LuxR solo hybrids [PDF]

Frontiers in Cellular and Infection Microbiology, 2015
A sub-group of LuxR family of proteins that plays important roles in quorum sensing, a process of cell-cell communication, is widespread in proteobacteria.
Daniel ePassos da Silva, Hitendra eKumar Patel, Juan Francisco González, Giulia eDevescovi, Xianfa eMeng, Sonia eCovaceuszach, Doriano eLamba, Sujatha eSubramoni, Vittorio eVenturi   +8 more
doaj   +4 more sources

Genomic characterization of bacteria from the ultra-oligotrophic Madison aquifer: insight into the archetypical LuxI/LuxR and identification of novel LuxR solos [PDF]

BMC Research Notes, 2021
Objectives To characterize the bacterial community of Wind Cave’s Madison aquifer through whole-genome sequencing, and to better understand the bacterial ecology by identifying genes involved in acyl-homoserine lactone (AHL) based quorum-sensing (QS ...
Peter C. Wengert, Narayan H. Wong, Hazel A. Barton, Han Ming Gan, André O. Hudson, Michael A. Savka   +5 more
doaj   +3 more sources

The Diverse Roles of the Histone-Like Nucleoid Structuring (H-NS) Protein in <i>Vibrio parahaemolyticus</i>. [PDF]

Genet Res (Camb)
The histone‐like nucleoid structuring (H‐NS) protein is a global transcriptional regulator critical for bacterial genome organization and gene expression. In Vibrio parahaemolyticus, H‐NS represses virulence factors such as thermostable direct hemolysin (TDH), type III secretion systems (T3SS1/T3SS2), and type VI secretion systems (T6SS1/T6SS2).
Tang H, Zhang Y.
europepmc   +2 more sources

Expanding the LuxR-type receptor functional repertoire: Protein-protein interactions in quorum sensing regulation. [PDF]

PLoS Pathogens
Quorum sensing (QS) enables bacteria to coordinate gene expression in response to population density, with LuxR-type transcription factors playing a central role in this process for many Gram-negative species. Traditionally understood as ligand-activated
Caleb P Mallery, Jon E Paczkowski
doaj   +2 more sources

Effects on LuxR-Regulated Bioluminescence of Cyclodextrin-Acyl-L-Homoserine Lactone Hybrids. [PDF]

Chembiochem
Cyclodextrin‐N‐acyl‐L‐Homoserine‐Lactone conjugates are synthetized, purified and fully characterized. The study of modulation of LuxR‐regulated bioluminescence production has demonstrated that one of the compounds exhibits not only the capacity to induce bioluminescence with an EC50 value of 64 µM, but also the ability to reduce bioluminescence with ...
Tinet N, Lesur D, Queneau Y, Soulère L, Djedaini-Pilard F, Bonnet V.   +5 more
europepmc   +2 more sources

luxR Homolog-Linked Biosynthetic Gene Clusters in Proteobacteria

mSystems, 2018
Microbes are a major source of antibiotics, pharmaceuticals, and other bioactive compounds. The production of many specialized microbial metabolites is encoded in biosynthetic gene clusters (BGCs). A challenge associated with natural product discovery is
Carolyn A. Brotherton, Marnix H. Medema, E. Peter Greenberg   +2 more
doaj   +3 more sources

Specificity of Signal-Binding via Non-AHL LuxR-Type Receptors.

PLoS ONE, 2015
Quorum sensing is a typical communication system among Gram-negative bacteria used to control group-coordinated behavior via small diffusible molecules dependent on cell number.
Sophie Brameyer, Ralf Heermann
doaj   +5 more sources

Chimeric LuxR Transcription Factors Rewire Natural Product Regulation [PDF]

Angewandte Chemie, 2020
Abstract LuxR‐type transcriptional activator proteins frequently regulate the expression of biosynthetic gene clusters (BGCs). With only a fraction of bacterial BGCs being expressed under standard culturing conditions, modulation of LuxRs would provide a powerful approach to activate silent clusters.
Ruchira Mukherji, Shuaibing Zhang, Somak Chowdhury, Pierre Stallforth   +3 more
openaire   +4 more sources

Microbial Primer: LuxR-LuxI Quorum Sensing.

Microbiology (Reading, England), 2023
Quorum sensing is a term describing bacterial cell-to-cell communication systems for monitoring and responding to changes in population density. This primer serves as an introduction to the canonical LuxR-LuxI-type quorum sensing circuits common to many species of Gram-negative bacteria.
Soto-Aceves, Martin P., Diggle, Stephen P., Greenberg, E. Peter   +2 more
openaire   +3 more sources

Directed evolution of Vibrio fischeri LuxR signal sensitivity [PDF]

Journal of Bioscience and Bioengineering, 2016
LuxR is the core component of Vibrio fischeri quorum sensing. It acts as the transcriptional activator by binding to its cognate signaling molecules 3-oxo-hexanoyl-homoserine lactone (3OC6HSL). Although several acyl-HSLs with 3-oxo groups are known to activate LuxR with similar efficiency, acyl-HSLs without 3-oxo groups are very weak inducers.
Yuki Kimura, Yohei Tashiro, Kyoichi Saito, Shigeko Kawai-Noma, Daisuke Umeno   +4 more
openaire   +3 more sources