Genomic characterization of bacteria from the ultra-oligotrophic Madison aquifer: insight into the archetypical LuxI/LuxR and identification of novel LuxR solos [PDF]
BMC Research Notes, 2021 Objectives To characterize the bacterial community of Wind Cave’s Madison aquifer through whole-genome sequencing, and to better understand the bacterial ecology by identifying genes involved in acyl-homoserine lactone (AHL) based quorum-sensing (QS ...
Peter C. Wengert +5 more
doaj +3 more sources
Studies on synthetic LuxR solo hybrids [PDF]
Frontiers in Cellular and Infection Microbiology, 2015 A sub-group of LuxR family of proteins that plays important roles in quorum sensing, a process of cell-cell communication, is widespread in proteobacteria.
Daniel ePassos da Silva +8 more
doaj +4 more sources
A walk into the LuxR regulators of Actinobacteria: phylogenomic distribution and functional diversity. [PDF]
PLoS ONE, 2012 LuxR regulators are a widely studied group of bacterial helix-turn-helix (HTH) transcription factors involved in the regulation of many genes coding for important traits at an ecological and medical level.
Catarina Lopes Santos +3 more
doaj +5 more sources
Effect of PAS-LuxR Family Regulators on the Secondary Metabolism of Streptomyces
Antibiotics, 2022 With the development of sequencing technology and further scientific research, an increasing number of biosynthetic gene clusters associated with secondary Streptomyces metabolites have been identified and characterized.
Naifan Zhang +3 more
doaj +3 more sources
mSystems, 2018 Microbes are a major source of antibiotics, pharmaceuticals, and other bioactive compounds. The production of many specialized microbial metabolites is encoded in biosynthetic gene clusters (BGCs). A challenge associated with natural product discovery is
Carolyn A. Brotherton +2 more
doaj +3 more sources
A Nutrient-Responsive LuxR Regulator Orchestrates Effector Gene Expression Across the Legionella Genus. [PDF]
Mol MicrobiolLexR1 is a LuxR‐type regulator that links nutrient sensing to effector gene expression in Legionella. Activated by a casamino acid‐derived ligand, LexR1 directly controls multiple effector genes using a conserved regulatory element present in numerous putative effectors across different Legionella species.
Adler C, Segal G.
europepmc +2 more sources
Intragenic suppression of a mutation: Characterization of an autoinducer-independent LuxR [PDF]
FEMS Microbiology Letters, 1995 The Vibrio fischeri luminescence genes are activated by the LuxR protein and a diffusible signal termed the autoinducer. LuxR consists of two domains, a C-terminal transcriptional activator domain, and an N-terminal autoinducer-binding domain, which serves to regulate the function of the C-terminal domain.
K A, Poellinger +3 more
openaire +2 more sources
Orphan LuxR regulators of quorum sensing [PDF]
FEMS Microbiology Reviews, 2009 Bacteria can modulate their behavior by releasing and responding to the accumulation of signal molecules. This population co-ordination, referred to as quorum sensing, is prevalent in Gram-negative and Gram-positive bacteria. The essential constituents of quorum-sensing systems include a signal producer, or synthase, and a cognate transcriptional ...
Arati V, Patankar, Juan E, González
openaire +2 more sources
Directed Evolution of the Transcriptional Activator LuxR [PDF]
Journal of Bioscience and Bioengineering, 2006 LuxR-type proteins are responsible for density-dependent transcriptional regulation in quorum-sensing systems that employ acyl-homoserine lactones (acyl-HSLs) as signal molecules. The Vibrio fischeri lux operon, which includes LuxR, has been well studied and shown to function in E. coli.
Yuki Kimura +4 more
openaire +3 more sources
LitR directly upregulates autoinducer synthesis and luminescence in Aliivibrio logei [PDF]
PeerJ, 2021 LitR is a master-regulator of transcription in the ainS/R and luxS/PQ quorum sensing (QS) systems of bacteria from Vibrio and Aliivibrio genera. Here, we for the first time directly investigated the influence of LitR on gene expression in the luxI/R QS ...
Sergey Bazhenov +7 more
doaj +2 more sources