Results 31 to 40 of about 6,063 (169)

Microbial Primer: LuxR-LuxI Quorum Sensing

Microbiology, 2023
Quorum sensing is a term describing bacterial cell-to-cell communication systems for monitoring and responding to changes in population density. This primer serves as an introduction to the canonical LuxR-LuxI-type quorum sensing circuits common to many species of Gram-negative bacteria.
Martin P. Soto-Aceves, Stephen P. Diggle, E. Peter Greenberg   +2 more
openaire   +2 more sources

Whole genome sequencing and analysis reveal insights into the genetic structure, diversity and evolutionary relatedness of luxI and luxR homologs in bacteria belonging to the Sphingomonadaceae family

Frontiers in Cellular and Infection Microbiology, 2015
Here we report the draft genomes and annotation of four N-acyl homoserine lactone (AHL)-producing members from the family Sphingomonadacae. Comparative genomic analyses of 62 Sphingomonadacae genomes were performed to gain insights into the distribution
Han Ming eGan, Huan You Gan, Nurul Hawa Ahmad, Nazrin Abd Aziz, Andre O Hudson, Michael A Savka   +5 more
doaj   +1 more source

CsrA modulates luxR transcript levels in Vibrio fischeri [PDF]

FEMS Microbiology Letters, 2012
The quorum-sensing and CsrA regulons of Vibrios control overlapping cellular functions during growth. Hence, the potential exists for regulatory network interactions between the pathways that enable them to be coordinately controlled. In Vibrio cholerae, CsrA indirectly modulates the activity of LuxO in the quorum-sensing signaling pathway.
Joshua W, Williams, A L, Ritter, Ann M, Stevens   +2 more
openaire   +2 more sources

Positive autoregulation of the Vibrio fischeri luxR gene. LuxR and autoinducer activate cAMP-catabolite gene activator protein complex-independent and -dependent luxR transcription.

Journal of Biological Chemistry, 1992
The LuxR protein is a transcriptional activator involved in regulation of the genes required for bioluminescence (lux) in the marine bacterium Vibrio fischeri. Transcription of the two divergently oriented lux operons (luxR and luxICDABEG) is activated by LuxR in the presence of a diffusible inducer (autoinducer).
G S, Shadel, T O, Baldwin
openaire   +2 more sources

Binding mode exploration of LuxR-thiazolidinedione analogues, e-pharmacophore-based virtual screening in the designing of LuxR inhibitors and its biological evaluation [PDF]

Journal of Biomolecular Structure and Dynamics, 2016
Master quorum sensing (QS) regulator LuxR of Vibrio harveyi is a unique member of the TetR protein superfamily. Recent studies have demonstrated the contribution of thiazolidinedione analogues in blocking QS by decreasing the DNA-binding ability of LuxR. However, the precise mechanism of thiazolidinedione analogues binding to LuxR is still unclear.
Sundaraj, Rajamanikandan, Jeyaraman, Jeyakanthan, Pappu, Srinivasan   +2 more
openaire   +2 more sources

Autoinducer-fluorophore conjugates enable FRET in LuxR proteins in vitro and in cells [PDF]

Nature Chemical Biology, 2022
Cell-to-cell signaling, or quorum sensing (QS), in Gram-negative bacteria is governed by small molecule signals (N-acyl L-homoserine lactones, AHLs) and their cognate intracellular receptors (LuxR-type proteins). The mechanistic underpinnings of QS in these bacteria are severely limited due to the challenges of isolating and manipulating most LuxR-type
Matthew J. Styles, Michelle E. Boursier, Margaret A. McEwan, Emma E. Santa, Margrith E. Mattmann, Betty L. Slinger, Helen E. Blackwell   +6 more
openaire   +2 more sources

Chimeric LuxR Transcription Factors Rewire Natural Product Regulation [PDF]

Angewandte Chemie, 2020
Abstract LuxR‐type transcriptional activator proteins frequently regulate the expression of biosynthetic gene clusters (BGCs). With only a fraction of bacterial BGCs being expressed under standard culturing conditions, modulation of LuxRs would provide a powerful approach to activate silent clusters.
Ruchira Mukherji, Shuaibing Zhang, Somak Chowdhury, Pierre Stallforth   +3 more
openaire   +3 more sources

A σE-Mediated Temperature Gauge Controls a Switch from LuxR-Mediated Virulence Gene Expression to Thermal Stress Adaptation in Vibrio alginolyticus. [PDF]

PLoS Pathogens, 2016
In vibrios, the expression of virulence factors is often controlled by LuxR, the master quorum-sensing regulator. Here, we investigate the interplay between LuxR and σE, an alternative sigma factor, during the control of virulence-related gene expression
Dan Gu, Min Guo, Minjun Yang, Yuanxing Zhang, Xiaohui Zhou, Qiyao Wang   +5 more
doaj   +1 more source

Computational Exploration of Putative LuxR Solos in Archaea and Their Functional Implications in Quorum Sensing

Frontiers in Microbiology, 2017
LuxR solos are unexplored in Archaea, despite their vital role in the bacterial regulatory network. They assist bacteria in perceiving acyl homoserine lactones (AHLs) and/or non-AHLs signaling molecules for establishing intraspecies, interspecies, and ...
Akanksha Rajput, Manoj Kumar
doaj   +1 more source

Interkingdom Signaling of the Insect Pathogen Photorhabdus luminescens with Plants Via the LuxR solo SdiA

Microorganisms, 2023
In bacteria, group-coordinated behavior such as biofilm formation or virulence are often mediated via cell–cell communication, a process referred to as quorum sensing (QS). The canonical QS system of Gram-negative bacteria uses N-acyl homoserine lactones
Nazzareno Dominelli, Alice Regaiolo, Leon Willy, Ralf Heermann   +3 more
doaj   +1 more source