Results 101 to 110 of about 4,988 (293)

Baicalein Inhibits the Staphylococcus aureus Biofilm and the LuxS/AI-2 System in vitro

Infection and Drug Resistance, 2023
Yanni Mao, Panpan Liu, Haorong Chen, Yuxia Wang, Caixia Li, Quiqin Wang Veterinary Pharmacology Lab, School of Animal Science and Technology, Ningxia University, Yinchuan, 750021, People’s Republic of ChinaCorrespondence: Quiqin Wang, Email nxwgq@126 ...
Mao Y, Liu P, Chen H, Wang Y, Li C, Wang Q   +5 more
doaj  

Spatial Engineering of Gas Diffusion Layers Overcomes Mass Transport Limitations in Fuel Cells

Advanced Science, EarlyView.
ABSTRACT Mass transport limitations at high current densities hinder polymer electrolyte fuel cell (PEFC) performance due to inefficient water management and reactant distribution. Gas diffusion layer (GDL) perforation offers a potential solution as an alternative to complex flow‐field modifications.
Shangwei Zhou, Wenjia Du, Jianuo Chen, Yunsong Wu, Bochen Li, Jieyang Li, Linlin Xu, Winfried Kockelmann, Meng Lin, Marc‐Olivier Coppens, Paul R Shearing, Rhodri Jervis, Thomas S. Miller   +12 more
wiley   +1 more source

A Bioinspired Three‐Dimensional High‐Curvature Nano‐Interface Integrated Microfluidic Chip for Small Extracellular Vesicles Enrichment and Machine Learning‐Assisted Prostate Cancer Precision Diagnosis

Advanced Science, EarlyView.
A biotin‐modified artificial insertion peptide functionalized three‐dimensional high‐curvature‐TiO2 nano‐interface was engineered in a microfluidic chip to improve the isolation efficiency of small extracellular vesicles (sEVs). This chip balanced affinity, releasability, and extendibility, enabling high‐throughput recovery of sEVs for downstream ...
Le Wang, Yizhong Liang, Manan Sulaiman, Jiaqi Du, Ming Jiang, Zhihua Wang, Xu Yu, Li Xu   +7 more
wiley   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

The LuxS/AI-2 quorum sensing system regulates osmotic adaptation, motility, and type VI secretion system in Halomonas elongata

Frontiers in Microbiology
As a widespread quorum sensing (QS) system in bacteria, the LuxS/AI-2 QS system can coordinate bacterial group behaviors to adapt to diverse environments. However, its roles in halophiles remain largely unexplored.
Zhuo Wang, Yanyan Yang, Xin Guo, Chuanxu Wang, Jing Yang, Yajie Niu, Xin Li   +6 more
doaj   +1 more source

Harnessing MDM2‐Mediated Targeted Degradation of Transcriptional and Epigenetic Machinery to Disrupt Oncogenic Addictions in Pediatric Sarcoma

Advanced Science, EarlyView.
MDM2 dependency in pediatric sarcomas is driven by a novel p53‐independent oncogenic cistrome alongside canonical p53 pathway suppression. This study introduces MDM2‐recruiting transcriptional and epigenetic machinery degraders (MDM2‐TEMADs) as a novel precision oncology modality.
Jiawei Zhou, Xian Guan, Nan Li, Ying Zhang, Long Xie, Xingze Huang, Zhipeng Zhu, Zhuolin Ren, Xiaoyan Yu, Hanjun Guo, Yuanfang Wu, Lin Ma, Suya Zheng, Jingyao Zhang, Jiyang Liu, Victor Kuanmin Lee, Wenhao Chen, H. Phillip Koeffler, Jinhu Wang, Xin Han, Ye Chen, Liang Xu   +21 more
wiley   +1 more source

Construction and Biological Characteristics of a luxS-Deleted Mutant of Vibrio parahaemolyticus [PDF]

Shipin Kexue
In this study, a luxS-deleted mutant of Vibrio parahaemolyticus was successfully constructed by homologous recombination technology, and the growth capacity, 4,5-dihydroxy-2,3-pentanedione (DPD) production, biofilm formation, motility, drug ...
YANG Jingxian, WANG Qingqing, DONG Xiaogang, XU Haoting, ZHONG Qingping
doaj   +1 more source

TME/NIR Dual‐Responsive Zinc‐Based Targeted Nanoagonist for Multimodal Amplification of STING‐Mediated Cancer Immunotherapy

Advanced Science, EarlyView.
A multifunctional nanoagonist (cDZ@IP) enables nano‐metabolite–driven multimodal activation of the STING pathway and enhanced immune recognition, achieving potent antitumor immunity and suppressing tumor growth and metastasis. This strategy highlights the rational design of therapeutic metabolites and establishes a new paradigm bridging nanomedicine ...
Kepeng Hu, Jiawei Wang, Wei Zhang, Zhixuan Wu, Jing Chen, Yujing He, Xiyue Duan, Yaoting He, Xin Xin, Haoyi Xiang, Yijing Wang, Chengwei Wu, Yang Yi, Qing Meng, Yuqian Qiao, Kui Cheng, Xiaojun Long, Zhangfa Song   +17 more
wiley   +1 more source

Radiotherapy Enhances the Oncolytic Efficacy of the Novel Oncolytic Herpesvirus VG161 and Amplifies Its Antitumor Immunity in Breast Cancer

Advanced Science, EarlyView.
RT promotes VG161 replication in BC and its immunostimulatory transgenes expression, which is mediated by the upregulation of GADD34 and HVEM caused by RT. The combination therapy with VG161 and RT increases the abundances of tumor‐infiltrating lymphocytes and elicits potent systemic antitumor immunity, thereby effectively inhibiting local tumors and ...
Lijuan Lyu, Ming Yi, Ji Chen, Zeda Zhao, Ruocen Liao, Yingnan Wang, Shengtao Hu, Jun Ding, Ronghua Zhao, William Jia, Yinan Shen, Yongchang Wei, Kongming Wu, Zhijun Dai   +13 more
wiley   +1 more source

Functional Analysis of luxS in Staphylococcus aureus Reveals a Role in Metabolism but Not Quorum Sensing. [PDF]

, 2006
The function of AI-2 in many bacteria and the physiological role of LuxS, the enzyme responsible for its production, remain matters of debate. Here, we show that in Staphylococcus aureus the luxS gene forms a monocistronic transcriptional unit under the ...
Holden,, Matthew T. G., Winzer, Klaus, Holden, MTG, Winzer, K, Williams, P, Qazi, SN, Doherty, Neil, Doherty, N, Qazi, Saara N., Williams, Paul   +9 more
core   +1 more source