Results 21 to 30 of about 57 (44)

Considerations for the development of a field-based medical device for the administration of adjunctive therapies for snakebite envenoming. [PDF]

Toxicon X, 2023
Werner RM, Soffa AN.
europepmc   +1 more source

PLA₂ Inhibitor Varespladib as an Alternative to the Antivenom Treatment for Bites from Nikolsky's Viper Vipera berus nikolskii. [PDF]

Toxins (Basel), 2020
Zinenko O, Tovstukha I, Korniyenko Y.
europepmc   +1 more source

sPLA2-IIA modifies progranulin deficiency phenotypes in mouse models. [PDF]

Mol Neurodegener
Yang C, Du H, Lee GB, Uematsu M, He W, Doré E, Yu W, Sanford EJ, Smolka MB, Boilard E, Baskin JM, Hao L, Hu F.   +12 more
europepmc   +1 more source

<i>In vitro</i>-<i>in vivo</i> discord: A preclinical study of AZD2716 and its racemate with comparison to varespladib for the development of snake venom sPLA2 inhibitors. [PDF]

Toxicon X
Hearth JL, Surovtseva Y, Karjala Z, Casewell NR, Giang K, Lewin MR.   +5 more
europepmc   +1 more source

Structural and Functional Aspects of Targeting the Secreted Human Group IIA Phospholipase A₂. [PDF]

Molecules, 2020
Kim RR, Chen Z, Mann TJ, Bastard K, F Scott K, Church WB.   +5 more
europepmc   +1 more source

Targeting Key Enzymatic Snake Venom Proteins Using Repurposed Small Molecule Inhibitors: Emerging Adjuncts to Antivenom Therapy. [PDF]

Int J Mol Sci
Reghu N, Kiruthika S, Santhosh AK, Narayanan AL, Geetha KG, Sidheek N, Danthuluri SS, Nair BG, Vanuopadath M.   +8 more
europepmc   +1 more source

Phospholipase A2 Isoforms in Lung Immunity and Respiratory Infections: Potential Targets for Next-Generation Therapy. [PDF]

Int J Mol Sci
Joshi S, Walter K, Hamiel D, Saxena D, Zheng J.   +4 more
europepmc   +1 more source

Delayed Oral LY333013 Rescues Mice from Highly Neurotoxic, Lethal Doses of Papuan Taipan (Oxyuranus scutellatus) Venom

, 2020
Lewin, Matthew R,; Gutiérrez, José María,; Samuel, Stephen P,; Herrera, María,; Bryan-Quirós, Wendy,; Lomonte, Bruno,; Bickler, Philip E,; Bulfone, Tommaso C,; Williams, David J,
core  

Tissue damaging toxins in snake venoms: mechanisms of action, pathophysiology and treatment strategies. [PDF]

Commun Biol
Bittenbinder MA, van Thiel J, Cardoso FC, Casewell NR, Gutiérrez JM, Kool J, Vonk FJ.   +6 more
europepmc   +1 more source

Oral varespladib for the treatment of snakebite envenoming in India and the USA (BRAVO): a phase II randomised clinical trial. [PDF]

BMJ Glob Health
Gerardo CJ, Carter RW, Kumar S, Shirazi FM, Kotehal SD, Akpunonu PD, Bhalla A, Schwartz RB, Bammigatti C, Manikath N, Mukherjee PP, Arnold TC, Wolk BJ, S Sheikh S, Sollee DR, Vearrier DJ, Francis SJ, Aizenberg A, Kumar H, Ravikumar MK, Sarkar S, Haston T, Micciche A, Oomman SC, Owen JL, Ritter BA, Samuel SP, Lewin MR, Platts-Mills TF.   +28 more
europepmc   +1 more source