Results 31 to 40 of about 57 (44)

Exploration of the Inhibitory Potential of Varespladib for Snakebite Envenomation. [PDF]

Molecules, 2018
Wang Y, Zhang J, Zhang D, Xiao H, Xiong S, Huang C.   +5 more
europepmc   +1 more source

The synergistic inhibition of atherogenesis in apoE-/- mice between pravastatin and the sPLA2 inhibitor varespladib (A-002). [PDF]

J Lipid Res, 2009
Shaposhnik Z, Wang X, Trias J, Fraser H, Lusis AJ.   +4 more
europepmc   +1 more source

Proinflammatory secreted phospholipase A2 type IIA (sPLA-IIA) induces integrin activation through direct binding to a newly identified binding site (site 2) in integrins αvβ3, α4β1, and α5β1. [PDF]

J Biol Chem, 2015
Fujita M, Zhu K, Fujita CK, Zhao M, Lam KS, Kurth MJ, Takada YK, Takada Y.   +7 more
europepmc   +1 more source

Comparative efficacy of a secretory phospholipase A2 inhibitor with conventional anti-inflammatory agents in a rat model of antigen-induced arthritis. [PDF]

Arthritis Res Ther, 2011
Coulthard LG, Costello J, Robinson B, Shiels IA, Taylor SM, Woodruff TM.   +5 more
europepmc   +1 more source

Relationship between levels of secreted phospholipase A₂ groups IIA and X in the airways and asthma severity. [PDF]

Clin Exp Allergy, 2011
Hallstrand TS, Lai Y, Ni Z, Oslund RC, Henderson WR, Gelb MH, Wenzel SE.   +6 more
europepmc   +1 more source

Secreted phospholipase A2 group X overexpression in asthma and bronchial hyperresponsiveness. [PDF]

Am J Respir Crit Care Med, 2007
Hallstrand TS, Chi EY, Singer AG, Gelb MH, Henderson WR.   +4 more
europepmc   +1 more source

Matrix metalloproteinase-2 negatively regulates cardiac secreted phospholipase A2 to modulate inflammation and fever. [PDF]

J Am Heart Assoc, 2015
Berry E, Hernandez-Anzaldo S, Ghomashchi F, Lehner R, Murakami M, Gelb MH, Kassiri Z, Wang X, Fernandez-Patron C.   +8 more
europepmc   +1 more source

Pro-inflammatory secretory phospholipase A2 type IIA binds to integrins alphavbeta3 and alpha4beta1 and induces proliferation of monocytic cells in an integrin-dependent manner. [PDF]

J Biol Chem, 2008
Saegusa J, Akakura N, Wu CY, Hoogland C, Ma Z, Lam KS, Liu FT, Takada YK, Takada Y.   +8 more
europepmc   +1 more source

Suppressive effect of secretory phospholipase A2 inhibitory peptide on interleukin-1beta-induced matrix metalloproteinase production in rheumatoid synovial fibroblasts, and its antiarthritic activity in hTNFtg mice. [PDF]

Arthritis Res Ther, 2009
Thwin MM, Douni E, Arjunan P, Kollias G, Kumar PV, Gopalakrishnakone P.   +5 more
europepmc   +1 more source

The Development of Novel Therapies for Rheumatoid Arthritis. [PDF]

Expert Opin Ther Pat, 2008
Quan LD, Thiele GM, Tian J, Wang D.
europepmc   +1 more source