Results 31 to 40 of about 1,603 (190)
Study of the interaction of Huperzia saururus Lycopodium alkaloids with the Acetylcholinesterase enzyme [PDF]
, 2013 In the present study, we describe and compare the binding modes of three Lycopodium alkaloids (sauroine, 6-hydroxylycopodine and sauroxine; isolated from Huperzia saururus) and huperzine A with the enzyme acetylcholinesterase. Refinement and rescoring of
Agnese, Mariel +6 more
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One-step synthesis of Lycopodium alkaloid (-)-huperzine W via Suzuki-Miyaura coupling [PDF]
, 2012 The first total synthesis of (−)-huperzine W (1) has been achieved. Key element of the synthesis is a highly convergent assemblage for the two rings system of target molecule utilizing an efficient Suzuki-Miyaura coupling reaction between chiral iodide 2
Huai-Rong Luo +3 more
core +1 more source
Natural AChE inhibitors from plants and their contribution to Alzheimer´s disease therapy [PDF]
, 2013 As acetylcholinesterase (AChE) inhibitors are an important therapeutic strategy in Alzheimer's disease, efforts are being made in search of new molecules with anti-AChE activity.
Alza, Natalia Paola +4 more
core +2 more sources
Taxonomic Distribution of Medicinal Plants for Alzheimer’s Disease: A Cue to Novel Drugs
International Journal of Alzheimer’s Disease, Volume 2020, Issue 1, 2020., 2020 Alzheimer’s disease (AD) is a neurodegenerative disorder manifested by decline in memory and mild cognitive impairment leading to dementia. Despite global occurrence of AD, the severity and hence onset of dementia vary among different regions, which was correlated with the customary use of medicinal herbs and exposure level to the causatives.
Muhammad Kamran +9 more
wiley +1 more source
Selection of Reference Genes for Expression Analysis in Chinese Medicinal Herb Huperzia serrata
Frontiers in Pharmacology, 2019 Huperzine A (HupA) is a powerful and selective inhibitor of acetylcholinesterase. It has attracted widespread attention endangering the ultimate plant sources of Lycopodiaceae family.
Mengquan Yang +8 more
doaj +1 more source
Evidence-Based Complementary and Alternative Medicine, Volume 2020, Issue 1, 2020., 2020 Uremic pruritus (UP) is prevalent among patients with end‐stage renal disease (ESRD), which causes severe itching and affects their quality of life. Additionally, patients experience fatigue and depression, and an increased risk of mortality has also been reported.
Ping-Hsun Lu +6 more
wiley +1 more source
Molecules, 2014 Four new lycodine-type alkaloids, namely 16-hydroxyhuperzine B (1), N-methyl-11-acetoxyhuperzine B (2), 8,15-dihydrolycoparin A (3) and (7S,12S,13R)-huperzine D-16-O-β-d-glucopyranoside (4), along with ten known analogues 5−14, were isolated from the ...
Dong-Bo Zhang +4 more
doaj +1 more source
Effects of the Hydroethanolic Extract of Lycopodium selago L. on Scopolamine-Induced Memory Deficits in Zebrafish [PDF]
, 2021 This scientific research focused on the production of hydroethanolic extract of the plant species Lycopodium selago L. (L. selago) by the ultrasound-assisted extraction (USAE) and the identification of biocompounds with high antioxidant activity is of ...
Balseanu T. -A. +9 more
core +1 more source
Gastroenterology Research and Practice, Volume 2020, Issue 1, 2020., 2020 Aim. To investigate the expressions of neuroligin1 (NL1) and neurexin1 (NX1) in a mouse model of neuronal intestinal dysplasia (Tlx2-/- mice) and to explore their effects on colonic motility. Methods. Immunohistochemistry staining was employed to explore the histological appearances of NL1, NX1, the presynaptic marker of glutamatergic synapses VGLUT1 ...
Dongming Wang +6 more
wiley +1 more source
Enantioselective synthesis of lepadins A D from a phenylglycinol-derived hydroquinolone lactam [PDF]
, 2017 The marine alkaloids (-)-lepadins A-C and (+)-lepadin D, belonging to two diastereoisomeric series, were synthesized from an (R)-phenylglycinol-derived tricyclic lactam via a common cis-decahydroquinoline intermediate.
Amat Tusón, Mercedes +3 more
core +1 more source