Results 31 to 40 of about 1,605 (189)

Synthesis of the Core Structure of Palhinine A

European Journal of Organic Chemistry, Volume 2021, Issue 17, Page 2549-2556, May 7, 2021., 2021
An approach to the core structure of the alkaloid palhinine A is presented. Starting with an easily available 2,5‐disubstituted cyclohexanone an allyl group was introduced into the 3‐position by a Grignard addition/oxy‐Cope sequence. A subsequent transannular aldol reaction led to a bicyclo[2.2.2]octanone derivative.
Dominik Gaugele, Martin E. Maier
wiley   +1 more source

Shenjinhuoxue Mixture Attenuates Inflammation, Pain, and Cartilage Degeneration by Inhibiting TLR‐4 and NF‐κB Activation in Rats with Osteoarthritis: A Synergistic Combination of Multitarget Active Phytochemicals

Oxidative Medicine and Cellular Longevity, Volume 2021, Issue 1, 2021., 2021
Osteoarthritis (OA), a highly prevalent chronic joint disease, involves a complex network of inflammatory mediators that not only triggers pain and cartilage degeneration but also accelerates disease progression. Traditional Chinese medicinal shenjinhuoxue mixture (SHM) shows anti‐inflammatory and analgesic effects against OA with remarkable clinical ...
Xiaoqin Ma, Chenxia Hao, Zhaokang Zhang, Huiting Jiang, Weixia Zhang, Jingjing Huang, Xiaofei Chen, Wanhua Yang, Raul Dominguez Perles   +8 more
wiley   +1 more source

Chemical Composition of Cynanchum auriculatum Royle Ex Wight and Its Potential Role in Ameliorating Colitis. [PDF]

Food Sci Nutr
In this study, the water extract of Cynanchum auriculatum Royle ex Wight root (CW) was prepared and its chemical composition was characterized using UPLC‐Q‐TOF‐MS. CW significantly alleviated DSS‐induced colitis in mice, as demonstrated by increased colon length, reduced disease activity index scores, and decreased histological damage in colon tissues.
Li S, Sun Y, Peng H, You R, Bai F, Chen D, Abdin M, Peng C, Li X, Cai H, Chen G.   +10 more
europepmc   +2 more sources

Comparison of 454-ESTs from Huperzia serrata and Phlegmariurus carinatus reveals putative genes involved in lycopodium alkaloid biosynthesis and developmental regulation

BMC Plant Biology, 2010
Background Plants of the Huperziaceae family, which comprise the two genera Huperzia and Phlegmariurus, produce various types of lycopodium alkaloids that are used to treat a number of human ailments, such as contusions, swellings and strains.
Steinmetz André, Sun Yongzhen, Song Jingyuan, Wu Qiong, Sun Chao, Li Ying, Luo Hongmei, Chen Shilin   +7 more
doaj   +1 more source

Quinolizidine alkaloid biosynthesis: recent advances and future prospects

Frontiers in Plant Science, 2012
Lys-derived alkaloids, including piperidine, quinolizidine, indolizidine, and lycopodium alkaloids, are widely distributed throughout the plant kingdom.
Somnuk eBunsupa, Mami eYamazaki, Kazuki eSaito, Kazuki eSaito   +3 more
doaj   +1 more source

Selection of Reference Genes for Expression Analysis in Chinese Medicinal Herb Huperzia serrata

Frontiers in Pharmacology, 2019
Huperzine A (HupA) is a powerful and selective inhibitor of acetylcholinesterase. It has attracted widespread attention endangering the ultimate plant sources of Lycopodiaceae family.
Mengquan Yang, Mengquan Yang, Shiwen Wu, Wenjing You, Wenjing You, Amit Jaisi, Youli Xiao, Youli Xiao, Youli Xiao   +8 more
doaj   +1 more source

Taxonomic Distribution of Medicinal Plants for Alzheimer’s Disease: A Cue to Novel Drugs

International Journal of Alzheimer’s Disease, Volume 2020, Issue 1, 2020., 2020
Alzheimer’s disease (AD) is a neurodegenerative disorder manifested by decline in memory and mild cognitive impairment leading to dementia. Despite global occurrence of AD, the severity and hence onset of dementia vary among different regions, which was correlated with the customary use of medicinal herbs and exposure level to the causatives.
Muhammad Kamran, Rehana Kousar, Shakir Ullah, Siraj Khan, Muhammad Farooq Umer, Haroon Ur Rashid, Zakir Khan, Muhammad Ijaz Khan Khattak, Mujeeb Ur Rehman, Francesco Panza   +9 more
wiley   +1 more source

Enantioselective synthesis of lepadins A D from a phenylglycinol-derived hydroquinolone lactam [PDF]

, 2017
The marine alkaloids (-)-lepadins A-C and (+)-lepadin D, belonging to two diastereoisomeric series, were synthesized from an (R)-phenylglycinol-derived tricyclic lactam via a common cis-decahydroquinoline intermediate.
Amat Tusón, Mercedes, Bosch Cartes, Joan, Griera Farres, Rosa, Pinto, Alexandre   +3 more
core   +1 more source

Lycodine-Type Alkaloids from Lycopodiastrum casuarinoides and Their Acetylcholinesterase Inhibitory Activity

Molecules, 2014
Four new lycodine-type alkaloids, namely 16-hydroxyhuperzine B (1), N-methyl-11-acetoxyhuperzine B (2), 8,15-dihydrolycoparin A (3) and (7S,12S,13R)-huperzine D-16-O-β-d-glucopyranoside (4), along with ten known analogues 5−14, were isolated from the ...
Dong-Bo Zhang, Jian-Jun Chen, Qiu-Yan Song, Li Zhang, Kun Gao   +4 more
doaj   +1 more source

An Apriori Algorithm‐Based Association Rule Analysis to Identify Herb Combinations for Treating Uremic Pruritus Using Chinese Herbal Bath Therapy

Evidence-Based Complementary and Alternative Medicine, Volume 2020, Issue 1, 2020., 2020
Uremic pruritus (UP) is prevalent among patients with end‐stage renal disease (ESRD), which causes severe itching and affects their quality of life. Additionally, patients experience fatigue and depression, and an increased risk of mortality has also been reported.
Ping-Hsun Lu, Jui-Lin Keng, Ko-Li Kuo, Yu-Fang Wang, Yu-Chih Tai, Chan-Yen Kuo, Priscila Souza   +6 more
wiley   +1 more source