Results 211 to 220 of about 3,794 (236)

Synthesis and antiplasmodial activity of lycorine derivatives

Bioorganic & Medicinal Chemistry, 2010
Twenty seven lycorine derivatives were prepared and evaluated for their in vitro antimalarial activity against chloroquine-sensitive strains of Plasmodium falciparum. The best antiplasmodial activities were achieved with lycorine derivatives that present free hydroxyl groups at C-1 and C-2 or esterified as acetates or isobutyrates.
Juan C, Cedrón, David, Gutiérrez, Ninoska, Flores, Angel G, Ravelo, Ana, Estévez-Braun   +4 more
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ChemInform Abstract: LYCORIN, SYNTH.‐UNTERSUCHUNGEN

Chemischer Informationsdienst, 1973
AbstractVersuche zur Darstellung der für die Synthese der Titelverbindung (I) benötigten Vorstufe (IIa) bzw. der Modellverbindung (IIb) werden beschrieben.
S. F. DYKE, M. SAINSBURY, J. R. EVANS
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Catalytic Asymmetric Assembly of Octahydroindolones: Divergent Synthesis of Lycorine‐type Amaryllidaceae Alkaloids (+)‐α‐Lycorane and (+)‐Lycorine

Chemistry – A European Journal, 2014
AbstractWe report the first catalytic asymmetric approach to octahydroindolones and a divergent enantioselective synthesis of perhydroindole alkaloids, as exemplified by lycorine‐type Amaryllidaceae alkaloids (+)‐α‐lycorane and (+)‐lycorine, from a common intermediate by using a highly concise route.
Zhongwen, Sun, Mingtao, Zhou, Xiang, Li, Xueling, Meng, Fangzhi, Peng, Hongbin, Zhang, Zhihui, Shao   +6 more
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Lycorine and its Derivatives for Anticancer Drug Design

Mini-Reviews in Medicinal Chemistry, 2010
Amaryllidaceae alkaloids are extensively studied for their biological activities in several pharmaceutical areas, including, for example, Alzheimer's disease for which galanthamine has already reached the market. Among this chemical family, lycorine displays very promising anti-tumor properties.
Lamoral-Theys, Delphine, Decaestecker, Christine, Mathieu, V, Dubois, Jacques, Kornienko, Alexander, Kiss, Robert, Evidente, Antonio, Pottier, Laurent   +7 more
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New lycorine-type alkaloid from Lycoris traubii and evaluation of antitrypanosomal and antimalarial activities of lycorine derivatives

Bioorganic & Medicinal Chemistry, 2008
A new lycorine derivative LT1 (4) was isolated from the aerial part and bulbs of Lycoris traubii Hayward (Amaryllidaceae). Its structure including absolute configuration was established by spectroscopic analysis and semi-synthesis to be 1-O-(3'S)-hydroxybutanoyllycorine.
Yosuke, Toriizuka, Eri, Kinoshita, Noriyuki, Kogure, Mariko, Kitajima, Aki, Ishiyama, Kazuhiko, Otoguro, Haruki, Yamada, Satoshi, Omura, Hiromitsu, Takayama   +8 more
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ChemInform Abstract: Total Synthesis of (‐)‐Lycorine and (‐)‐2‐epi‐Lycorine by Asymmetric Conjugate Addition Cascade.

ChemInform, 2009
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Ken‐ichi Yamada, Mitsuaki Yamashita, Takaaki Sumiyoshi, Katsumi Nishimura, Kiyoshi Tomioka   +4 more
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Synthesis of the amaryllidaceae alkaloid, lycorine

Journal of the Chemical Society, Chemical Communications, 1975
A key intermediate for the total synthesis of lycorine has been prepared in racemic form; the optically pure form of this epoxylycorinane lactam, obtained from lycorine, has been reconverted into the alkaloid.
Yoshisuke Tsuda, Takehiro Sano, Jun'Ichi Taga, Kimiaki Isobe, Jun Toda, Hiroshi Irie, Hirokazu Tanaka, Sh�z� Takagi, Masae Yamaki, Mayumi Murata   +9 more
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ChemInform Abstract: SYNTHESIS OF LYCORINE‐TYPE ALKALOIDS PART 1, 1‐DESOXY‐LYCORIN‐7‐ONE

Chemischer Informationsdienst, 1974
AbstractSorbinsäureester (I) wird durch Lithium‐diisopropylamid zum nicht‐konjugierten Dien (II) umgelagert, aus dem mit dem β‐Nitrostyrol (III) das Diels‐Alder‐Addukt (IV)erhaltenwird.Mit Zink/Schwefesäure erfolgt die Reduktion zu einer Hydroxamsäure (V), die durch Lithiumalanat zum Hydroxylamin (VI) weiter reduziert wird.
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(--)-Siculinine: A Lycorine-Type Alkaloid from Sternbergia sicula

Journal of Natural Products, 1989
(−)-Siculinine was obtained from Turkish Sternbergia sicula.
Richomme P., Pabuccuoglu V., Gozler T., Freyer A.J., Shamma M.   +4 more
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Antiinflammatory effects of lycorine and haemanthidine

Phytotherapy Research, 1998
The antiinflammatory effects of lycorine and haemanthidine which were isolated from Sternbergia clusiana (Ker-Gawl.) Ker-Gawl ex Sprengel growing in Turkey were evaluated in mice by the carrageenan-induced oedema test. Antiinflammatory activities of lycorine and haemanthidine were higher than that of indomethacin. © 1998 John Wiley & Sons, Ltd.
G. Çitoğlu, M. Tanker, B. Gümüşel
openaire   +1 more source